Photostimulation of Ventral Tegmental Area-Insular Cortex Dopaminergic Inputs Enhances the Salience to Consolidate Aversive Taste Recognition Memory via D1-Like Receptors DOI Creative Commons
Elvi Gil-Lievana, Gerardo Ramírez-Mejía, Oscar Urrego-Morales

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: March 11, 2022

Taste memory involves storing information through plasticity changes in the neural network of taste, including insular cortex (IC) and ventral tegmental area (VTA), a critical provider dopamine. Although VTA-IC dopaminergic pathway has been demonstrated, its role to consolidate taste recognition remains poorly understood. We found that photostimulation neurons VTA or terminals TH-Cre mice improves salience subthreshold novel stimulus regardless hedonic value, without altering their palatability. Importantly, inhibition D1-like receptor into IC impairs facilitate consolidation an aversive memory. Finally, our results showed conditioned aversion IC. It is concluded dopamine activity from required increase enabling Notably, both innate learned memories but not appetitive

Language: Английский

Is it harmful or helpful? Examining the causes and consequences of generative AI usage among university students DOI Creative Commons
Muhammad Abbas,

Farooq Ahmed Jam,

Tariq Iqbal Khan

et al.

International Journal of Educational Technology in Higher Education, Journal Year: 2024, Volume and Issue: 21(1)

Published: Feb. 16, 2024

Abstract While the discussion on generative artificial intelligence, such as ChatGPT, is making waves in academia and popular press, there a need for more insight into use of ChatGPT among students potential harmful or beneficial consequences associated with its usage. Using samples from two studies, current research examined causes usage university students. Study 1 developed validated an eight-item scale to measure by conducting survey (N = 165). 2 used three-wave time-lagged design collect data 494) further validate test study’s hypotheses. also effects academic workload, time pressure, sensitivity rewards, quality students’ levels procrastination, memory loss, performance. provided evidence validity reliability scale. Furthermore, study revealed that when faced higher workload they were likely ChatGPT. In contrast, who sensitive rewards less Not surprisingly, was develop tendencies procrastination loss dampen Finally, had indirect outcomes through

Language: Английский

Citations

110

Neurobiology and systems biology of stress resilience DOI
Raffaël Kalisch, Scott J. Russo,

Marianne B. Müller

et al.

Physiological Reviews, Journal Year: 2024, Volume and Issue: 104(3), P. 1205 - 1263

Published: March 14, 2024

Stress resilience is the phenomenon that some people maintain their mental health despite exposure to adversity or show only temporary impairments followed by quick recovery. Resilience research attempts unravel factors and mechanisms make possible harness its insights for development of preventative interventions in individuals at risk acquiring stress-related dysfunctions. Biological has been lagging behind psychological social sciences but seen a massive surge recent years. At same time, progress this field hampered methodological challenges related finding suitable operationalizations study designs, replicating findings, modeling animals. We embed review behavioral, neuroimaging, neurobiological, systems biological findings adults critical methods discussion. find preliminary evidence hippocampus-based pattern separation prefrontal-based cognitive control functions protect against pathological fears aftermath singular, event-type stressors [as found fear-related disorders, including simpler forms posttraumatic stress disorder (PTSD)] facilitating perception safety. Reward system-based pursuit savoring positive reinforcers appear more generalized dysfunctions anxious-depressive spectrum resulting from severe longer-lasting (as depression, comorbid anxiety, PTSD). Links between preserved functioning these neural under neuroplasticity, immunoregulation, gut microbiome composition, integrity barrier blood-brain are beginning emerge. On basis, avenues pointed out.

Language: Английский

Citations

26

Overnight neuronal plasticity and adaptation to emotional distress DOI
Yesenia Cabrera, Karin J. Koymans, Gina R. Poe

et al.

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(4), P. 253 - 271

Published: March 5, 2024

Language: Английский

Citations

21

Schemas, reinforcement learning and the medial prefrontal cortex DOI
Oded Bein, Yael Niv

Nature reviews. Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

Citations

4

Laboratory models of post-traumatic stress disorder: The elusive bridge to translation DOI Creative Commons
Joseph E. Dunsmoor, Josh M. Cisler, Gregory A. Fonzo

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(11), P. 1754 - 1776

Published: March 23, 2022

Language: Английский

Citations

57

Tag and capture: how salient experiences target and rescue nearby events in memory DOI Creative Commons
Joseph E. Dunsmoor, Vishnu P. Murty, David Clewett

et al.

Trends in Cognitive Sciences, Journal Year: 2022, Volume and Issue: 26(9), P. 782 - 795

Published: July 13, 2022

Language: Английский

Citations

51

A model of autonomous interactions between hippocampus and neocortex driving sleep-dependent memory consolidation DOI Creative Commons
Dhairyya Singh, Kenneth A. Norman, Anna C. Schapiro

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(44)

Published: Oct. 24, 2022

How do we build up our knowledge of the world over time? Many theories memory formation and consolidation have posited that hippocampus stores new information, then “teaches” this information to neocortex time, especially during sleep. But it is unclear, mechanistically, how actually works—How are these systems able interact periods with virtually no environmental input accomplish useful learning shifts in representation? We provide a framework for thinking about question, neural network model simulations serving as demonstrations. The composed neocortical areas, which replay memories one another completely autonomously simulated Oscillations leveraged support error-driven leads changes representation behavior. has non–rapid eye movement (NREM) sleep stage, where dynamics between tightly coupled, helping reinstate high-fidelity versions attractors, REM more freely explore existing attractors. find alternating NREM stages, alternately focuses model’s on recent remote facilitates graceful continual learning. thus an account can without any external drive cortical protect old integrated.

Language: Английский

Citations

48

Sleep selectively and durably enhances memory for the sequence of real-world experiences DOI
Nicholas B. Diamond, Stephanie Simpson, Daniel Baena

et al.

Nature Human Behaviour, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Language: Английский

Citations

1

Sleep preferentially consolidates negative aspects of human memory: Well-powered evidence from two large online experiments DOI Creative Commons
Dan Denis, Kristin E. G. Sanders, Elizabeth A. Kensinger

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(44)

Published: Oct. 24, 2022

Research suggests that sleep benefits memory. Moreover, it is often claimed selectively memory for emotionally salient information over neutral information. However, not all scientists are convinced by this relationship [e.g., J. M. Siegel. Curr. Sleep Med. Rep. , 7, 15–18 (2021)]. One criticism of the overall and literature—like other literature—is many studies underpowered lacking in generalizability [M. Cordi, B. Rasch. Opin. Neurobiol. 67, 1–7 (2021)], thus leaving evidence mixed confusing to interpret. Because large replication sorely needed, we recruited 250 participants spanning various age ranges backgrounds an effort confirm sleep’s preferential emotional consolidation benefit using a well-established task. We found negative objects at expense their paired backgrounds, confirming our prior work clearly demonstrating role formation. In second experiment also sample, examined whether effect generalized positive while demonstrated better compared did modulate effect. This research provides strong support sleep-specific on specifically more broadly affirms cognition.

Language: Английский

Citations

36

Research Review: Why do prospective and retrospective measures of maltreatment differ? A narrative review DOI Creative Commons
Oonagh Coleman, Jessie R. Baldwin, Tim Dalgleish

et al.

Journal of Child Psychology and Psychiatry, Journal Year: 2024, Volume and Issue: 65(12), P. 1662 - 1677

Published: Aug. 16, 2024

Background Childhood maltreatment contributes to a large mental health burden worldwide. Different measures of childhood are not equivalent and may capture meaningful differences. In particular, prospective retrospective identify different groups individuals differentially associated with psychopathology. However, the reasons behind these discrepancies have yet been comprehensively mapped. Methods this review, we draw on multi‐disciplinary research present an integrated framework explain measurement disagreement. Results We identified three interrelated domains. First, methodological issues related data collection methods. Second, role memory in influencing reports maltreatment. Finally, motivations disclose, withhold, or fabricate information about Conclusions A greater understanding disagreement point new ways conceptualise assess Furthermore, it help uncover mechanisms underlying maltreatment‐related psychopathology targets for novel interventions.

Language: Английский

Citations

6