Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis

Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 9

Published: Jan. 18, 2022

New research has shown that the development of osteoarthritis (OA) is regulated by different mechanisms cell death and types cytokines. Therefore, elucidating mechanism action among various cytokines, processes OA important towards better understanding pathogenesis progression disease. This paper reviews in relation to cytokine-triggered death. We describe morphological features molecular pyroptosis, apoptosis, necroptosis, ferroptosis, summarize current findings defining between OA.

Language: Английский

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Interleukin-6 promotes ferroptosis in bronchial epithelial cells by inducing reactive oxygen species-dependent lipid peroxidation and disrupting iron homeostasis

Bioengineered, Journal Year: 2021, Volume and Issue: 12(1), P. 5279 - 5288

Published: Jan. 1, 2021

Asthma occurs accompanied by the ferroptosis in bronchial epithelial cells, during which Interleukin-6 (IL-6) plays a key role. However, associations between IL-6, and asthma have not been reported. Bronchial cells BEAS-2B were induced different concentrations of IL-6 cell viability was detected MTT assay. The TBARS production rate corresponding kit. expression oxidative stress-related indexes ELISA. Iron Assay Kits total iron levels ferrous ion (Fe2+) levels. Labile pool assay used to detect unstable pool. ferroptosis-related proteins Western blot. To further examine mechanism action, inhibitor Ferrostatin 1 (Fer-1), antioxidant NAC, supplement Fe added. We found that decreased activity, promoted lipid peroxidation, disrupted homeostasis death cells. pretreatment with Ferrostatin-1 (Fer-1) NAC partially reversed effect on peroxidation while augmented effect. Overall, promotes inducing reactive oxygen species (ROS)-dependent disrupting homeostasis.

Language: Английский

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Fighting age-related orthopedic diseases: focusing on ferroptosis

Bone Research, Journal Year: 2023, Volume and Issue: 11(1)

Published: March 1, 2023

Abstract Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation and lipid peroxidation. It closely related to multiple biological processes, including iron metabolism, polyunsaturated fatty acid the biosynthesis compounds with antioxidant activities, glutathione. In past 10 years, increasing evidence has indicated potentially strong relationship between ferroptosis onset progression age-related orthopedic diseases, such as osteoporosis osteoarthritis. Therefore, in-depth knowledge regulatory mechanisms in diseases may help improve disease treatment prevention. This review provides an overview recent research on its influences bone cartilage homeostasis. begins brief systemic metabolism ferroptosis, particularly potential ferroptosis. presents discussion role promotion loss degradation inhibition osteogenesis. Finally, it focuses future targeting treat intention inspiring further clinical development therapeutic strategies.

Language: Английский

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Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Feb. 2, 2022

Ferroptosis is one of the newly discovered forms cell-regulated death characterized by iron-dependent lipid peroxidation. Extensive research has focused on roles ferroptosis in tumors, blood diseases, and neurological diseases. Some recent findings have indicated that may also be related to occurrence development inflammatory arthritis. a potential therapeutic target, few studies vitro animal models shown implications pathogenesis This mini review discussed common features between rheumatoid arthritis (RA), evaluated applications regulators preclinical clinical research. critical issues worth paying attention were raised guide future efforts.

Language: Английский

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TRPM7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the PKCα-NOX4 axis

Redox Biology, Journal Year: 2022, Volume and Issue: 55, P. 102411 - 102411

Published: July 19, 2022

Language: Английский

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The mechanism of ferroptosis and its related diseases

Molecular Biomedicine, Journal Year: 2023, Volume and Issue: 4(1)

Published: Oct. 16, 2023

Abstract Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation lipid peroxides, provides novel avenue for delving into intersection metabolism, oxidative stress, and disease pathology. We have witnessed mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, traumatic tissue injuries. By unraveling intricate underpinnings molecular machinery, contributors, signaling conduits, regulatory networks governing researchers aim bridge gap between intricacies this unique mode multifaceted implications health disease. In light rapidly advancing landscape ferroptosis research, we present comprehensive review aiming at extensive in origins progress human diseases. This concludes careful analysis potential treatment approaches carefully designed either inhibit or promote ferroptosis. Additionally, succinctly summarized therapeutic targets compounds that hold promise targeting within various facet underscores burgeoning possibilities manipulating as strategy. summary, enriched insights both investigators practitioners, while fostering an elevated comprehension latent translational utilities. revealing basic processes investigating possibilities, crucial resource scientists medical aiding deep understanding effects situations.

Language: Английский

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Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Oct. 14, 2024

Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against

Language: Английский

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Icariin inhibits chondrocyte ferroptosis and alleviates osteoarthritis by enhancing the SLC7A11/GPX4 signaling

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 133, P. 112010 - 112010

Published: April 17, 2024

Chondrocyte ferroptosis plays a critical role in the pathogenesis of osteoarthritis (OA), regulated by SLC7A11/GPX4 signaling pathway. Icariin (ICA), flavonoid glycoside, exhibits strong anti-inflammatory and antioxidant activities. This study investigated whether ICA could modulate to inhibit chondrocyte alleviate OA.

Language: Английский

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Icariin inhibits hypoxia/reoxygenation‐induced ferroptosis of cardiomyocytes via regulation of the Nrf2/HO‐1 signaling pathway

FEBS Open Bio, Journal Year: 2021, Volume and Issue: 11(11), P. 2966 - 2976

Published: Aug. 18, 2021

Myocardial infarction (MI) is caused by the formation of plaques in arterial walls, leading to a decrease blood flow heart and myocardium injury as result hypoxia. Ferroptosis crucial event myocardial injury, icariin (ICA) exerts protective effects against injury. Here, we investigated mechanism ICA hypoxia/reoxygenation (H/R)-induced ferroptosis cardiomyocytes. H9C2 cells were subjected H/R induction. The content lactate dehydrogenase levels oxidative stress intracellular ferrous ion Fe2+ measured. markers (ACSL4 GPX4) detected. H/R-induced cultured with presence or absence inducer (erastin). Znpp (an HO-1 inhibitor) was added ICA-treated verify role Nrf2/HO-1 pathway. showed reduced viability, enhanced content, increased ACSL4, decreased GPX4. inhibited Erastin treatment reversed inhibitory effect on cells. expression Nrf2 reduced, whereas this trend. Inhibition pathway ferroptosis. Collectively, our results suggest that attenuates cardiomyocytes activating signaling

Language: Английский

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Natural medicines of targeted rheumatoid arthritis and its action mechanism

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 1, 2022

Rheumatoid arthritis (RA) is an autoimmune disease involving joints, with clinical manifestations of joint inflammation, bone damage and cartilage destruction, dysfunction deformity, extra-articular organ damage. As important source new drug molecules, natural medicines have many advantages, such as a wide range biological effects small toxic side effects. They become hot spot for the vast number researchers to study various diseases develop therapeutic drugs. In recent years, research in treatment RA has made remarkable achievements. These mainly include flavonoids, polyphenols, alkaloids, glycosides terpenes. Among them, resveratrol, icariin, epigallocatechin-3-gallate, ginsenoside, sinomenine, paeoniflorin, triptolide paeoniflorin are star RA. Its mechanism treating involves these aspects: anti-inflammation, anti-oxidation, immune regulation, pro-apoptosis, inhibition angiogenesis, osteoclastogenesis, fibroblast-like synovial cell proliferation, migration invasion. This review summarizes potential on briefly discusses their mechanisms action against

Language: Английский

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