The Anti-Inflammatory and Immunomodulatory Activities of Natural Products to Control Autoimmune Inflammation

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 24(1), P. 95 - 95

Published: Dec. 21, 2022

Inflammation is an integral part of autoimmune diseases, which are caused by dysregulation the immune system. This involves imbalance between pro-inflammatory versus anti-inflammatory mediators. These mediators include various cytokines and chemokines; defined subsets T helper/T regulatory cells, M1/M2 macrophages, activating/tolerogenic dendritic antibody-producing/regulatory B cells. Despite availability many anti-inflammatory/immunomodulatory drugs, severe adverse reactions associated with their long-term use often high costs impediments in effectively controlling disease process. Accordingly, suitable alternatives being sought for these conventional drugs. Natural products offer promising adjuncts/alternatives this regard. The specific compounds isolated from dietary/medicinal plant extracts have permitted rigorous studies on disease-modulating activities mechanisms involved therein. Here, we describe basic characteristics, action, preventive/therapeutic applications 5 well-characterized natural product (Resveratrol, Curcumin, Boswellic acids, Epigallocatechin-3-gallate, Triptolide). been tested extensively animal models autoimmunity as well limited clinical trials patients having corresponding diseases. We focused our description predominantly cell-mediated such rheumatoid arthritis, multiple sclerosis, Type 1 diabetes, ulcerative colitis, psoriasis.

Language: Английский

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Immunomodulatory, Anti-Inflammatory, and Anti-Cancer Properties of Ginseng: A Pharmacological Update

Molecules, Journal Year: 2023, Volume and Issue: 28(9), P. 3863 - 3863

Published: May 3, 2023

Ginseng, a medicinal plant of the genus Panax, boasts rich historical record usage that dates back to Paleolithic period. This botanical is extensively acknowledged and consumed in Eastern countries for its therapeutic properties, and, Western countries, it becoming increasingly popular as remedy fatigue asthenia. review provides an update on current research pertaining ginseng isolated compounds, namely, ginsenosides polysaccharides. The primary focus three crucial pharmacological activities, immunomodulation, anti-inflammatory, anti-cancer effects. encompasses studies both compounds various extracts obtained from root, leaves, berries.

Language: Английский

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Peptide-anchored neutrophil membrane-coated biomimetic nanodrug for targeted treatment of rheumatoid arthritis

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Jan. 13, 2023

Macrophage polarization determines the production of cytokines that fuel initiation and evolution rheumatoid arthritis (RA). Thus, modulation macrophage might represent a potential therapeutic strategy for RA. However, coordinated macrophages in synovium synovial fluid has not been achieved thus far. Herein, we develop biomimetic ApoA-I mimetic peptide-modified neutrophil membrane-wrapped F127 polymer (R4F-NM@F127) targeted drug delivery during RA treatment. Due to high expression adhesion molecules chemokine receptors on neutrophils, membrane coating can endow nanocarrier with synovitis-targeting ability, subsequent recruitment under chemotactic effects IL-8. Moreover, R4F peptide modification further endows ability target SR-B1 receptor, which is highly expressed fluid. Long-term vivo imaging shows R4F-NM@F127 preferentially accumulates inflamed joints engulfed by macrophages. After loading anti-inflammatory celastrol (Cel), R4F-NM@F127-Cel significant reduction hepatotoxicity, effectively inhibits inflammation alleviates joint damage reprogramming polarization. our results highlight as promising option treatment

Language: Английский

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Resveratrol as a privileged molecule with antioxidant activity

Food Chemistry Advances, Journal Year: 2023, Volume and Issue: 3, P. 100539 - 100539

Published: Nov. 21, 2023

Oxidative stress has a significant impact on the occurrence of many chronic diseases. Antioxidants have ability to prevent, postpone or treat effects free radicals. Resveratrol is polyphenol from class stilbenes. The importance this compound determined by its numerous biological properties. strong antioxidant potential special significance, because way it acts in prevention and treatment action direct, inhibiting production reactive species, indirect, influencing activity enzymes. In case analyzing known methods, was observed that RSV had higher capacity than standard used. Also, vitro vivo studies demonstrate neurodegenerative, cardiovascular renal addition, active preeclampsia infertility. An important aspect fact reduce counteract adverse some anticancer agents.

Language: Английский

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Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomized controlled trials

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: March 22, 2023

Objective To evaluate safety and efficacy of dietary polyphenols in the treatment rheumatoid arthritis (RA). Methods CNKI, Pubmed, Cochrane library, Embase were searched to collect randomized controlled trials (RCTs) RA. The databases from time their establishment November 8nd, 2022. After 2 reviewers independently screened literature, extracted data, assessed risk bias included studies, Meta-analysis was performed using RevMan5.4 software. Results A total 49 records (47 RCTs) finally included, involving 3852 participants 15 types (Cinnamon extract, Cranberry Crocus sativus L. Curcumin, Garlic Ginger Hesperidin, Olive oil, Pomegranate Puerarin, Quercetin, Resveratrol, Sesamin, Tea polyphenols, Total glucosides paeony). Cinnamon Sesamin only involve 1 RCT. RCTs. paeony Curcumin more than 3 These RCTs showed that these could improve disease activity score for 28 joints (DAS28), inflammation levels or oxidative stress addition did not increase adverse events. Conclusion Dietary may DAS28, reduce C-reactive protein (CRP) erythrocyte sedimentation rate (ESR), stress, etc. However, are needed verify modify polyphenols. Systematic review registration https://www.crd.york.ac.uk/prospero/ , identifier CRD42022315645.

Language: Английский

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A comprehensive review on recent xanthine oxidase inhibitors of dietary based bioactive substances for the treatment of hyperuricemia and gout: Molecular mechanisms and perspective

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134832 - 134832

Published: Aug. 22, 2024

Language: Английский

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Adipose-derived stem cell exosomes loaded with icariin alleviates rheumatoid arthritis by modulating macrophage polarization in rats

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 18, 2024

Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by synovitis and cartilage destruction. The active compound, icariin (ICA), derived from the herb Epimedium, exhibits potent anti-inflammatory properties. However, its clinical utility limited water insolubility, poor permeability, low bioavailability. To address these challenges, we developed multifunctional drug delivery system—adipose-derived stem cells-exosomes (ADSCs-EXO)-ICA to target macrophages in synovial tissue modulate macrophage polarization M1 M2. High-performance liquid chromatography analysis confirmed 92.4 ± 0.008% loading efficiency for ADSCs-EXO-ICA. In vitro studies utilizing cellular immunofluorescence (IF) flow cytometry demonstrated significant inhibition of proliferation Enzyme-linked immunosorbent assay, transcriptomics, real-time quantitative PCR indicated that ADSCs-EXO-ICA promotes an M1-to-M2 phenotypic transition reducing glycolysis through ERK/HIF-1α/GLUT1 pathway. vivo, effectively accumulated joints. Pharmacodynamic assessments revealed decreased cytokine levels mitigated symptoms collagen-induced (CIA) rats. Histological micro computed tomography markedly ameliorated preserved cartilage. Further vivo suppresses promoting switch suppressing glycolysis. Western blotting supported therapeutic efficacy RA, confirming role modulating function energy metabolism regulation. Thus, this study not only introduces system significantly enhances anti-RA but also elucidates mechanism action inhibition. Graphical abstract

Language: Английский

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Corydalis decumbens and tetrahydropalmatrubin inhibit macrophages inflammation to relieve rheumatoid arthritis by targeting Fosl2

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 341, P. 119348 - 119348

Published: Jan. 11, 2025

Language: Английский

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Long noncoding RNA/circular RNA regulates competitive endogenous RNA networks in rheumatoid arthritis: molecular mechanisms and traditional Chinese medicine therapeutic significances

Annals of Medicine, Journal Year: 2023, Volume and Issue: 55(1), P. 973 - 989

Published: March 11, 2023

Rheumatoid arthritis (RA) is a systemic and autoimmune disease that mainly featured abnormal fibroblast-like synoviocyte (FLS) proliferation inflammatory cell infiltration. Abnormal expression or function of long noncoding RNAs (lncRNAs) circular (circRNAs) are closely related to human diseases, including RA. There has been increasing evidence showing in the competitive endogenous RNA (ceRNA) networks, both lncRNA circRNA vital biological functions cells. Nevertheless, exact mechanism ceRNA RA remains be investigated. Herein, we summarized molecular potencies lncRNA/circRNA-mediated networks RA, with emphasis on phenotypic regulation progression proliferation, invasion, inflammation apoptosis, as well role traditional Chinese medicine (TCM) treatment In addition, also discussed future direction potential clinical value which may provide reference for trials TCM therapy RA.Key messagesLong RNA/circular can work sponge participate pathogenesis rheumatoid arthritis.Traditional its agents have shown roles prevention via RNA.

Language: Английский

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CCL21/CCR7 axis as a therapeutic target for autoimmune diseases

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 121, P. 110431 - 110431

Published: June 16, 2023

Language: Английский

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