Development and validation of cuproptosis-related genes in synovitis during osteoarthritis progress DOI Creative Commons

Bohan Chang,

Zhehan Hu, Liang Chen

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 2, 2023

Osteoarthritis (OA) is one of the most common refractory degenerative joint diseases worldwide. Synovitis believed to drive cartilage destruction during OA pathogenesis. Cuproptosis a novel form copper-induced cell death. However, few studies have examined correlations between cuproptosis-related genes (CRGs), immune infiltration, and synovitis. Therefore, we analyzed CRGs in synovitis OA. Microarray datasets (GSE55235, GSE55457, GSE12021, GSE82107 GSE176308) were downloaded from Gene Expression Omnibus database. Next, conducted differential subtype analyses across Immune infiltration correlation performed explore association abundance Finally, single-cell RNA-seq profiling was using GSE176308 dataset investigate expression various clusters. We found that five (FDX1, LIPT1, PDHA1, PDHB, CDKN2A) significantly increased synovium. Moreover, abundant types cells infiltrated synovium OA, which correlated with CRGs. Additionally, revealed cellular composition complex their proportions varied greatly as progressed. The differed current study predicted cuproptosis may be involved pathogenesis screened could explored candidate biomarkers or therapeutic targets for

Language: Английский

Ferroptosis in inflammatory arthritis: A promising future DOI Creative Commons
Siyuan Chang, Mengshi Tang, Bikui Zhang

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: July 26, 2022

Ferroptosis is a kind of regulatory cell death (RCD) caused by iron accumulation and lipid peroxidation, which characterized mitochondrial morphological changes has complex network. been gradually emphasized in the pathogenesis inflammatory arthritis. In this review, we summarized relevant research on ferroptosis various arthritis including rheumatoid (RA), osteoarthritis, gout arthritis, ankylosing spondylitis, focused relationship between RA ferroptosis. patients with animal models RA, there was evidence overload as well dysfunction that may be associated inducers have shown good application prospects tumor therapy, some anti-rheumatic drugs such methotrexate sulfasalazine to modulating effects. These phenomena suggest role will worth further study. The development therapeutic strategies targeting for promising future.

Language: Английский

Citations

59
The RNA-binding protein SND1 promotes the degradation of GPX4 by destabilizing the HSPA5 mRNA and suppressing HSPA5 expression, promoting ferroptosis in osteoarthritis chondrocytes DOI

Min Lv,

Yuanzhen Cai,

Weikun Hou

et al.

Inflammation Research, Journal Year: 2022, Volume and Issue: 71(4), P. 461 - 472

Published: March 23, 2022

Language: Английский

Citations

57
Inhibition of ferroptosis by icariin treatment attenuates excessive ethanol consumption-induced atrial remodeling and susceptibility to atrial fibrillation, role of SIRT1 DOI
Liming Yu, Xue Dong, Tao Huang

et al.

APOPTOSIS, Journal Year: 2023, Volume and Issue: 28(3-4), P. 607 - 626

Published: Jan. 28, 2023

Language: Английский

Citations

31
Ferroptosis as an emerging target in rheumatoid arthritis DOI Creative Commons
Hui Zhao, Cheng Tang, Miao Wang

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 19, 2023

Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology. Due to the rise in incidence rate RA and limitations existing therapies, search for new treatment strategies has become a global focus. Ferroptosis novel programmed cell death characterized by iron-dependent lipid peroxidation, with distinct differences from apoptosis, autophagy, necrosis. Under conditions iron accumulation glutathione peroxidase 4 (GPX4) activity loss, lethal peroxide direct cause ferroptosis. mediates inflammation, oxidative stress, damage processes, also participates occurrence pathological progression inflammatory joint diseases including RA. This review provides insight into role mechanism ferroptosis discusses potential challenges as therapeutic strategy RA, effort provide targets prevention treatment.

Language: Английский

Citations

25
Targeting Ferroptosis in Bone-Related Diseases: Facts and Perspectives DOI Creative Commons
Hao Chen, Zhongyu Han, Yi Wang

et al.

Journal of Inflammation Research, Journal Year: 2023, Volume and Issue: Volume 16, P. 4661 - 4677

Published: Oct. 1, 2023

Abstract: Ferroptosis is a new cell fate decision discovered in recent years. Unlike apoptosis, autophagy or pyroptosis, ferroptosis characterized by iron-dependent lipid peroxidation and mitochondrial morphological changes. involved variety of physiological pathological processes. Since its discovery, has been increasingly studied concerning bone-related diseases. In this review, we focus on the latest research progress prospects, summarize regulatory mechanisms ferroptosis, discuss role pathogenesis diseases, such as osteoporosis (OP), osteoarthritis (OA), rheumatoid arthritis (RA), osteosarcoma (OS), well therapeutic potential. Keywords: death, iron accumulation, peroxidation, diseases

Language: Английский

Citations

24
Nrf2-mediated ferroptosis inhibition: a novel approach for managing inflammatory diseases DOI
Hang Han, Guojiang Zhang, Xiao Zhang

et al.

Inflammopharmacology, Journal Year: 2024, Volume and Issue: 32(5), P. 2961 - 2986

Published: Aug. 10, 2024

Language: Английский

Citations

15
Natural product-derived ferroptosis mediators DOI
Yili Chen,

Lin-An Xiong,

Lie‐Feng Ma

et al.

Phytochemistry, Journal Year: 2024, Volume and Issue: 219, P. 114002 - 114002

Published: Jan. 27, 2024

Language: Английский

Citations

14
Targeting ferroptosis in autoimmune diseases: Mechanisms and therapeutic prospects DOI

Yingzi Zheng,

Fangfang Yan, Shasha He

et al.

Autoimmunity Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 103640 - 103640

Published: Sept. 1, 2024

Language: Английский

Citations

11
Alleviated NCOA4-mediated ferritinophagy protected RA FLSs from ferroptosis in lipopolysaccharide-induced inflammation under hypoxia DOI
Yang Wang, Hongmei Ding,

Yuqun Zheng

et al.

Inflammation Research, Journal Year: 2024, Volume and Issue: 73(3), P. 363 - 379

Published: Jan. 8, 2024

Language: Английский

Citations

10
Advances in research on immunocyte iron metabolism, ferroptosis, and their regulatory roles in autoimmune and autoinflammatory diseases DOI Creative Commons

Liuting Zeng,

Kailin Yang,

Ganpeng Yu

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(7)

Published: July 4, 2024

Abstract Autoimmune diseases commonly affect various systems, but their etiology and pathogenesis remain unclear. Currently, increasing research has highlighted the role of ferroptosis in immune regulation, with cells being a crucial component body’s system. This review provides an overview discusses relationship between ferroptosis, programmed cell death cells, autoimmune diseases. Additionally, it summarizes key targets such as GPX4 TFR, responses. Furthermore, release multiple molecules, including damage-associated molecular patterns (DAMPs), following by is examined, these molecules further influence differentiation function thereby affecting occurrence progression Moreover, secrete factors or metabolites, which also impact target organs tissues involved Iron chelators, chloroquine its derivatives, antioxidants, calreticulin have been demonstrated to be effective animal studies for certain diseases, exerting anti-inflammatory immunomodulatory effects. Finally, brief summary future perspectives on are provided, aiming guide disease treatment strategies.

Language: Английский

Citations

9