Targeting oxidative stress, iron overload and ferroptosis in bone-degenerative conditions DOI Creative Commons
Junxiao Ren, Chen Meng, Li Rui

et al.

Turkish Journal of Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Abstract Introduction Bone-degenerative conditions, including osteoporosis, rheumatoid arthritis, and osteoarthritis, are major public health concerns worldwide, associated with oxidative stress iron overload that disrupts bone homeostasis. Ferroptosis, an iron-mediated form of cell death, has emerged as a critical factor in degeneration, necessitating comprehensive review its role these conditions. Content This comprehensively examined the latest research on stress, metabolism, ferroptosis related to biology focusing their interconnections potential therapeutic implications. The revealed affects various types, osteoclasts, osteoblasts, chondrocytes, contributing loss cartilage degradation. Iron homeostasis was found be crucial for function, both deficiency potentially leading pathological Ferroptosis regulation involves complex interplay between lipid peroxidation, antioxidant systems, SLC7A11-GSH-GPX4 network FSP1-CoQ10H2 pathway. Different lineages, mesenchymal stem cells, exhibit varied responses induction regulation. Summary Understanding molecular mechanisms underlying cells offers promising avenues developing targeted therapies bone-degenerative Outlook Future should focus elucidating specific roles different disorders exploring interventions targeting overload, pathways improve management debilitating

Language: Английский

Aucubin Promotes BMSCs Proliferation and Differentiation of Postmenopausal Osteoporosis Patients by Regulating Ferroptosis and BMP2 Signalling DOI Creative Commons
Yang Zheng,

Rongtai Sun,

Huan Yang

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(2)

Published: Jan. 1, 2025

Postmenopausal osteoporosis (PMOP) is a chronic systemic bone metabolism disorder. Promotion in the patterns of human marrow mesenchymal stem cells (hBMSCs) differentiation towards osteoblasts contributes to alleviating osteoporosis. Aucubin, natural compound isolated from well-known herbal medicine Eucommia, was previously shown possess various pharmacological effects. However, its effects on hBMSCs PMOP patients are unknown. The aim this present research investigate impact and underlying process aucubin cell proliferation osteogenic patients. ability inhibit ferroptosis induced by erastin detected; ROS production, ferrous ion levels, SOD, MDA, GPX activities were tested using commercial kits. Next, ALP staining, ARS RT-qPCR, RNA-sequencing, Western blot applied for determining mRNA protein expression levels associated with osteogenesis hBMSCs. study also explored involvement BMP2/Smads signalling promoting evaluated intervention an ovariectomised rat model. results indicated that significantly inhibited generation oxidative stress protected against Additionally, facilitated activating BMP2/SMADs pathway attenuated progression OVX rats, suggesting potential therapeutic benefit postmenopausal (PMOP).

Language: Английский

Citations

1
Ferroptosis and hepatocellular carcinoma: the emerging role of lncRNAs DOI Creative Commons
Haoran Chen,

Zhongyu Han,

Junyan Su

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 23, 2024

Hepatocellular carcinoma is the most common form of primary liver cancer and poses a significant challenge to medical community because its high mortality rate. In recent years, ferroptosis, unique cell death, has garnered widespread attention. Ferroptosis, which characterized by iron-dependent lipid peroxidation mitochondrial alterations, closely associated with pathological processes various diseases, including hepatocellular carcinoma. Long non-coding RNAs (lncRNAs), are type functional RNA, play crucial regulatory roles in variety biological processes. this manuscript, we review lncRNAs key aspects summarize research progress on ferroptosis-related

Language: Английский

Citations

7
Ferroptosis: a novel mechanism of cell death in ophthalmic conditions DOI Creative Commons
Yaqi Yang,

Yumeng Lin,

Zhongyu Han

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 27, 2024

Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation differs from death, such as apoptosis, necrosis, autophagy. Ferroptosis associated with variety physiological pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence development diseases targeting metabolic pathways signaling tumors, ischemic organ damage, other degenerative related to peroxidation. Increasing evidence suggests closely linked onset progression various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, retinoblastoma. Our review current research on reveals significant advancements our understanding pathogenesis, aetiology, treatment these conditions.

Language: Английский

Citations

5
Activation of osteoblast ferroptosis by risperidone accelerates bone loss in mice models of schizophrenia DOI Creative Commons

Fan Hongyan,

Zaihong Yang,

Lan Pang

et al.

Journal of Orthopaedic Surgery and Research, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 23, 2025

Language: Английский

Citations

0
Lipid metabolic reprogramming and associated ferroptosis in osteosarcoma: From molecular mechanisms to potential targets DOI Creative Commons

Zhongbao Yin,

Guanlu Shen,

Minjie Fan

et al.

Journal of bone oncology, Journal Year: 2025, Volume and Issue: unknown, P. 100660 - 100660

Published: Jan. 1, 2025

Language: Английский

Citations

0
Advances in Ferroptosis and Glucocorticoid-Induced Osteonecrosis of Femoral Head and Discussion of Related Ferroptosis Genes in Bone Metabolism or Oxidative Stress DOI

绍庚 王

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(01), P. 1717 - 1730

Published: Jan. 1, 2025

Language: Английский

Citations

0
SIRT6 inhibits endoplasmic reticulum stress-mediated ferroptosis by activating Nrf2/HO-1 signaling to alleviate osteoarthritis DOI
Jiaqi Shi, Li Chen, Xu Wang

et al.

Inflammation Research, Journal Year: 2025, Volume and Issue: 74(1)

Published: Feb. 10, 2025

Language: Английский

Citations

0
Ferritinophagy: a possible new iron-related metabolic target in canine osteoblastic osteosarcoma DOI Creative Commons
Karen A. Power, Rebecca Leandri, Giorgia Federico

et al.

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: March 24, 2025

Canine osteosarcomas (COS) are the most common bone tumors in dogs, characterized by high metastatic rates, poor prognosis, and responsiveness to routine therapies, which highlights need for new treatment targets. In this context, metabolism of neoplastic cells represents an increasingly studied element, as cancer depend on particular metabolic pathways that also elements vulnerability. Among these, tumor (TCs) show higher iron requirements sustain proliferation (so-called addiction), achieved increasing uptake and/or activating ferritinophagy, a process mediated Nuclear receptor Co-Activator 4 (NCOA4) leading mobilization from ferritin (Ft) deposits. Previous studies have shown COS overexpress Transferrin Receptor 1 (TfR1) increase uptake. study we evaluated immunohistochemical expression ferritinophagy-related proteins, namely Ferritin Heavy chain (FTH1) NCOA4, proliferating cell nuclear antigen (PCNA) canine normal osteoblastic osteosarcoma (COOS) samples. Normal samples revealed negative/weak immunoreactivity FTH1, NCOA4 PCNA <10% osteocytes. COOS majority showed PCNA. Our data suggest activation ferritinophagy responds feed their “iron addiction.” These data, though preliminary, further targeting potential strategy worthy be transferred into clinical practice.

Language: Английский

Citations

0
ATP-induced cell death: a novel hypothesis for osteoporosis DOI Creative Commons
Wei Wang,

Haolong Zhang,

Doblin Sandai

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11

Published: Dec. 14, 2023

ATP-induced cell death has emerged as a captivating realm of inquiry with profound ramifications in the context osteoporosis. This study unveils paradigm-shifting hypothesis that illuminates prospective involvement cellular demise etiology Initially, we explicate morphological attributes and delve into intricacies molecular machinery regulatory networks governing ATP homeostasis death. Subsequently, our focus pivots towards multifaceted interplay between pivotal protagonists, such bone marrow-derived mesenchymal stem cells, osteoblasts, osteoclasts, accentuating their potential contributions to secondary osteoporosis phenotypes, encompassing diabetic osteoporosis, glucocorticoid-induced postmenopausal Furthermore, probe alternative modalities demise, apoptosis, autophagy, necroptosis. Through an all-encompassing intricate nexus connecting primary goal is deepen comprehension underlying mechanisms propelling this malady establish theoretical bedrock underpin development pioneering therapeutic strategies.

Language: Английский

Citations

8
Computational recognition of regulator genes and signature for ferroptosis with implications on immunological properties and clinical management of atopic dermatitis DOI Creative Commons
Lei Xu, Wenjuan Guo,

Huirong Hao

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 6, 2024

Atopic dermatitis (AD) is a common chronic of autoimmune origin that considerably affects the quality life patients. Ferroptosis, newly regulated form cell death, essential for inflammation-related damage-associated molecular patterns (DAMPs). In this study, we aimed to identify ferroptosis regulators relevant AD pathogenesis and reveal mechanisms by which regulates AD.

Language: Английский

Citations

2