Journal of Biomedical Research,
Journal Year:
2024,
Volume and Issue:
38, P. 1 - 1
Published: Jan. 1, 2024
Hypertension
(HT)
is
a
major
risk
factor
for
cardiovascular
diseases.
Krüppel-like
factors
(KLFs)
are
important
transcription
in
eukaryotes.
Studies
have
reported
that
KLF4
and
KLF5
correlated
with
several
diseases,
whereas
population
studies
associations
between
HT
or
been
rarely
reported.
Thus,
the
current
study
aimed
to
examines
association
of
genetic
variants
mRNA
expression
levels
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(10), P. 5087 - 5087
Published: May 7, 2024
In
endothelial
cells,
miR-148a-3p
is
involved
in
several
pathological
pathways,
including
chronic
inflammatory
conditions.
However,
the
molecular
mechanism
of
states
is,
to
date,
not
fully
elucidated.
To
this
end,
we
investigated
involvement
mitochondrial
dysfunction
and
cell
death
pathways
human
aortic
cells
(teloHAECs)
treated
with
interleukin-6
(IL-6),
a
major
driver
vascular
dysfunction.
The
results
showed
that
during
IL6-activated
increased
protein
levels
sirtuin
7
(SIRT7)
(p
<
0.01),
stress
0.001),
apoptosis
decreased
expression
was
observed
0.01).
employment
miR-148a
mimic
counteracted
IL-6-induced
cytokine
release
0.01)
apoptotic
ameliorated
mitochondria
redox
homeostasis
respiration
targeted
relationship
between
SIRT7
predicted
by
bioinformatics
database
analysis
validated
via
dual-luciferase
reporter
assay.
Mechanistically,
targets
3′
untranslated
regions
mRNA,
downregulating
its
Herein,
these
vitro
support
role
miR-148a-3p/SIRT7
axis
counteracting
damage
inflammation,
unveiling
novel
target
for
future
strategies
prevent
ACS Biomaterials Science & Engineering,
Journal Year:
2024,
Volume and Issue:
10(4), P. 2235 - 2250
Published: March 6, 2024
The
use
of
exosomes
to
relieve
skin
injuries
has
received
considerable
attention.
PluronicF-127
hydrogel
(PF-127
hydrogel)
is
a
novel
biomaterial
that
can
be
used
carry
biomolecules.
This
study
sought
investigate
the
impact
originating
from
human
mesenchymal
stem
cells
(MSCs)
developed
adipose
tissue
(hADSC-Exos)
combined
with
PF-127
on
repair
and
explore
underlying
mechanism
using
in
vitro
vivo
experiments.
miR-148a-3p
most
expressed
microRNA
(miRNA)
hADSC-Exos.
We
found
had
better
efficacy
than
alone;
moreover,
knockdown
lowered
its
efficacy.
In
vitro,
we
observed
significant
increase
tumor-like
ability
HUVECs
after
exosome
treatment,
which
was
attenuated
knockdown.
Furthermore,
effects
hADSC-Exos
were
achieved
through
prevention
PTEN
triggering
phosphatidylinositol
3-kinase
(PI3K)/Akt
signaling.
conclusion,
our
results
demonstrated
promote
angiogenesis
wound
healing
by
delivering
have
effect
when
hydrogel,
may
an
alternative
strategy
healing.
Frontiers in Cardiovascular Medicine,
Journal Year:
2023,
Volume and Issue:
10
Published: May 25, 2023
Significant
progress
in
the
diagnosis
and
treatment
of
cardiovascular
disease
(CVD)
has
been
made
past
decade,
yet
it
remains
a
leading
cause
morbidity
mortality
globally,
claiming
an
estimated
17.9
million
deaths
per
year.
Although
encompassing
any
condition
that
affects
circulatory
system,
including
thrombotic
blockage,
stenosis,
aneurysms,
blood
clots
arteriosclerosis
(general
hardening
arteries),
most
prevalent
underlying
hallmark
CVD
is
atherosclerosis;
plaque-associated
arterial
thickening.
Further,
distinct
conditions
have
overlapping
dysregulated
molecular
cellular
characteristics
which
underlie
their
development
progression,
suggesting
some
common
aetiology.
The
identification
heritable
genetic
mutations
associated
with
atherosclerotic
vascular
(AVD),
particular
resulting
from
Genome
Wide
Association
Studies
(GWAS)
studies
significantly
improved
ability
to
identify
individuals
at
risk.
However,
increasingly
recognised
environmentally-acquired,
epigenetic
changes
are
key
factors
atherosclerosis
development.
Increasing
evidence
suggests
these
changes,
notably
DNA
methylation
misexpression
non-coding,
microRNAs
(miRNAs)
potentially
both
predictive
causal
AVD
This,
together
reversible
nature,
makes
them
useful
biomarkers
for
attractive
therapeutic
targets
reverse
progression.
We
consider
here
association
aberrant
miRNA
expression
aetiology
progression
atherosclerosis,
potential
novel
cell-based
strategies
target
therapeutically.
Metabolites,
Journal Year:
2023,
Volume and Issue:
13(3), P. 448 - 448
Published: March 19, 2023
Atherosclerosis
is
an
important
problem
in
modern
medicine,
the
keys
to
understanding
many
aspects
of
which
are
still
not
available
clinicians.
develops
as
a
result
complex
chain
events
cells
vascular
wall
and
peripheral
blood
flow
involved.
Endothelial
cells,
line
monolayer,
play
role
biology.
A
growing
body
evidence
strengthens
multifaceted
functions
endothelial
only
organize
barrier
between
tissues
but
also
act
regulators
hemodynamics
regulating
function
other
wall.
Krüppel-like
factors
(KLFs)
perform
several
biological
various
The
large
family
KLFs
humans
includes
18
members,
among
KLF2
KLF4
at
crossroads
cell
mechanobiology
immunometabolism,
roles
both
normal
atherosclerosis.
