hsa_circ_0088196 Predicts Adverse Pregnancy Outcomes in Preeclampsia Patients and Contributes to Endothelial Cell Injury Via Modulating the miR-145-5p/FLT1 Axis DOI

Yuelai Yang,

Lei Jiang,

Ruijing Chang

et al.

Reproductive Sciences, Journal Year: 2024, Volume and Issue: 31(12), P. 3825 - 3833

Published: Aug. 12, 2024

Language: Английский

Role of non-coding RNAs in the pathogenesis of viral myocarditis DOI Creative Commons

Zhijuan Kang,

Liang Zhang, Zuocheng Yang

et al.

Virulence, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Viral myocarditis (VMC) is a common inflammatory disease of the myocardium that characterized mainly by cell infiltration and cardiomyocyte necrosis. Coxsackievirus B3 (CVB3) cause VMC, although major progress has been made in treatment long-term prognosis still not ideal further research needed. Non-coding RNAs (ncRNAs) are RNA molecules without coding functions include microRNAs (miRNAs), long non-coding (lncRNAs) circular (circRNAs), which play extensive regulatory roles gene expression; however, their mechanisms action CVB3-induced VMC remain incompletely understood. Here, we review currently known various ncRNAs models, with focus on death, inflammation viral replication, aim providing reference for therapeutic or vaccine development VMC.

Language: Английский

Citations

0
circDENND4C serves as a sponge for miR-200b to drive non-small cell lung cancer advancement by regulating MMP-9 expression DOI Creative Commons

Yaming Lv,

Lan Wang, Yunhui Zhang

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 17, 2025

Introduction Lung cancer has a higher incidence and mortality rate than other cancers, especially non-small cell lung (NSCLC), accounting for 85% of the cases. The role circDENND4C/miR-200b/matrix metalloproteinase-9 (MMP-9) regulatory axis in NSCLC remains largely unknown. Methods lines were used to examine expression circDENND4C, miR-200b, MMP-9 via qRT-PCR or Western blot. target relationship was examined by RNA fluorescence situ hybridization (RNA-FISH), immunofluorescence (IF), dual-luciferase reporter system, quantitative real-time polymerase chain reaction (qRT-PCR), Then, count kit-8 (CCK-8) experiment, flow cytometry, migration/invasion assays performed assess biological function transfecting with their overexpression knockout plasmids A549 cells. Finally, proteins related adhesion tight junction further tested blot IF. Results circDENND4C found be highly expressed lines, while miR-200b lowly lines. Moreover, could sponge MMP-9. Subsequently, it observed that knockdown upregulation repressed proliferation cycle progression, increased apoptosis, hindered migration invasion. also circDENND4C/miR-200b/MMP-9 might involved influence tumor metastasis. Conclusions Altogether, our study reveals novel loop which may modulate indicating potential biomarkers diagnosis treatment NSCLC.

Language: Английский

Citations

0
Evaluation of CircHIPK3 Biomarker Potential in Breast Cancer DOI Creative Commons
Ensiyeh Bahadoran,

Davood Mohammadi,

Manijeh Jalilvand

et al.

Practical Laboratory Medicine, Journal Year: 2025, Volume and Issue: unknown, P. e00470 - e00470

Published: March 1, 2025

Nowadays, the investigation of circular RNAs (circRNAs) in various cancers is great interest. In this research, we evaluated circHIPK3 biomarker potential breast cancer (BC). The studied samples were 100 and adjacent normal tissues, plasma from 95 patients, 42 patients with fibroadenomatosis, 93 healthy donors. Illumina high-throughput Hi Seq 2000 sequencing performed expression profiling on 4 pairs cancerous tissues. For confirmation, Quantitative real-time fluorescent polymerase chain reaction (qRT-PCR) was used to detect level circHIPK3. CircHIPK3 diagnostic efficacy by receiver operating characteristic curve (ROC). Based bioinformatics results had highest tissues (P = 0.00034). Real-time showed upregulation BC comparison controls < 0.0001). potential, area under (AUC) result 0.8087 (95 % CI: 0.7309 0.8866, P Also, our high specificity sensitivity when alongside CA-15-3 CEA. Pathologic criteria evaluation that correlates tumor size. significantly upregulated compared controls, demonstrating an AUC 0.8087. size, indicating its relevance pathologic assessment BC.

Language: Английский

Citations

0
hsa_circ_0008285: Circular RNA with potential as a biomarker in ovarian cancer DOI
Khadijeh Elmizadeh, Ensiyeh Bahadoran, Zahra Mortezaei

et al.

Current Problems in Cancer, Journal Year: 2025, Volume and Issue: 56, P. 101208 - 101208

Published: April 26, 2025

Language: Английский

Citations

0
hsa_circ_0072309 Inhibits Oncogenesis in Hepatocellular Carcinoma by Epigenetic Activation of its Host Gene DOI
Tao Wang, Yanan Du,

Haiyang Song

et al.

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(4), P. 3251 - 3263

Published: Sept. 16, 2024

Language: Английский

Citations

1
Crosstalk between circular RNAs and the STAT3 signaling pathway in human cancer DOI

Mansour Almouh,

Chadi Soukkarieh, Morshed Kassouha

et al.

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Journal Year: 2024, Volume and Issue: 1867(4), P. 195051 - 195051

Published: Aug. 8, 2024

Language: Английский

Citations

0
hsa_circ_0088196 Predicts Adverse Pregnancy Outcomes in Preeclampsia Patients and Contributes to Endothelial Cell Injury Via Modulating the miR-145-5p/FLT1 Axis DOI

Yuelai Yang,

Lei Jiang,

Ruijing Chang

et al.

Reproductive Sciences, Journal Year: 2024, Volume and Issue: 31(12), P. 3825 - 3833

Published: Aug. 12, 2024

Language: Английский

Citations

0