The multifaceted perspectives on the regulation of lncRNAs in hepatocellular carcinoma ferroptosis: from bench-to-bedside DOI Creative Commons
Xin Jin,

C. Huang,

Yue Tian

et al.

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 3, 2024

Despite being characterized by high malignancy, morbidity, and low survival rates, the underlying mechanism of hepatocellular carcinoma (HCC) has not been fully elucidated. Ferroptosis, a non-apoptotic form regulated cell death, possesses distinct morphological, biochemical, genetic characteristics compared to other types death. Dysregulated actions within molecular network that regulates ferroptosis have identified as significant contributors progression HCC. Long non-coding RNAs (lncRNAs) emerged influential diverse cellular processes, regulating gene function expression through multiple mechanistic pathways. An increasing body evidence indicates deregulated lncRNAs are implicated in malignant events such proliferation, growth, invasion, metabolism influencing Therefore, elucidating inherent role modulatory functions on HCC might promote development novel therapeutic interventions for this disease. This review provides succinct overview roles ferroptosis-related treatment, aiming drive promising targets biomarkers patients.

Language: Английский

F-box/WD Repeat-Containing Protein 5 Promotes Breast Cancer Progression by Regulating Ferroptosis via Enhancing Krüppel-like Factor 13 Ubiquitination Through Phosphoinositide 3-Kinase/Serine/Threonine Protein Kinase Pathway DOI
Chen Chen, Hui Li, Ziyi Zhang

et al.

Rejuvenation Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Breast cancer (BC) is a prevalent malignancy among women. Evidence has indicated that F-box/WD repeat-containing protein 5 (FBXW5) crucial in oncogenesis and progression. However, the function of FBXW5 BC remains elusive. This work aims to explore regulatory mechanisms development BC. The expression pan-cancer breast invasive carcinoma (BRCA) was analyzed using Cancer Genome Atlas (TCGA) database. level enhanced tissues. Besides, inhibition significantly decreased cell viability by 49.05% MDA-MB-231 cells 62.30% MCF-7 cells. inhibited proliferation 66% 74% suppressed migration 77.2% 82.15% invasion 64.14% 71.33% In vivo, depletion reduced tumor weight 63.39% volume 65.17%. Moreover, silencing restrained lung metastases vivo. impact on malignant behavior mediated through regulation ferroptosis. Mechanically, facilitated Kruppel-like factor 13 (KLF13) degradation enhancing its ubiquitination. addition proliferation, migration, ferroptosis cells, which were neutralized KLF13 overexpression. knockdown led activation PI3K/AKT pathway. counteracted inhibitory effects invasion, as well promotion ferroptosis, reversed LY294002. conclusion, targeting may serve potential therapeutic strategy for modulating KLF13/PI3K/AKT axis.

Language: Английский

Citations

0
Targeting the initiator to activate both ferroptosis and cuproptosis for breast cancer treatment: progress and possibility for clinical application DOI Creative Commons

Murshid Imam,

Jiale Ji,

Zhijie Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 10, 2025

Breast cancer is the most commonly diagnosed worldwide. Metal metabolism pivotal for regulating cell fate and drug sensitivity in breast cancer. Iron copper are essential metal ions critical maintaining cellular function. The accumulation of iron triggers distinct death pathways, known as ferroptosis cuproptosis, respectively. Ferroptosis characterized by iron-dependent lipid peroxidation, while cuproptosis involves copper-induced oxidative stress. They increasingly recognized promising targets development anticancer drugs. Recently, compelling evidence demonstrated that interplay between plays a crucial role progression. This review elucidates converging pathways Moreover, we examined value genes associated with clinical diagnosis treatment cancer, mainly outlining potential co-targeting approach. Lastly, delve into current challenges limitations this strategy. In general, offers an overview interaction offering valuable perspectives further research treatment.

Language: Английский

Citations

0
Non-Coding RNAs as Key Regulators of Gasdermin-D Mediated Pyroptosis in Cancer Therapy DOI
Gaurav Gupta, Muhammad Afzal, Ehssan Moglad

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 261, P. 155490 - 155490

Published: July 26, 2024

Language: Английский

Citations

3
The multifaceted perspectives on the regulation of lncRNAs in hepatocellular carcinoma ferroptosis: from bench-to-bedside DOI Creative Commons
Xin Jin,

C. Huang,

Yue Tian

et al.

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 3, 2024

Despite being characterized by high malignancy, morbidity, and low survival rates, the underlying mechanism of hepatocellular carcinoma (HCC) has not been fully elucidated. Ferroptosis, a non-apoptotic form regulated cell death, possesses distinct morphological, biochemical, genetic characteristics compared to other types death. Dysregulated actions within molecular network that regulates ferroptosis have identified as significant contributors progression HCC. Long non-coding RNAs (lncRNAs) emerged influential diverse cellular processes, regulating gene function expression through multiple mechanistic pathways. An increasing body evidence indicates deregulated lncRNAs are implicated in malignant events such proliferation, growth, invasion, metabolism influencing Therefore, elucidating inherent role modulatory functions on HCC might promote development novel therapeutic interventions for this disease. This review provides succinct overview roles ferroptosis-related treatment, aiming drive promising targets biomarkers patients.

Language: Английский

Citations

2