Frontiers in Cell and Developmental Biology,
Journal Year:
2022,
Volume and Issue:
10
Published: Aug. 9, 2022
As
natural
nanoparticles,
exosomes
regulate
a
wide
range
of
biological
processes
via
modulation
its
components,
including
circular
RNAs
(circRNAs).
CircRNAs
are
novel
class
closed-loop
single-stranded
with
distribution,
and
play
diverse
roles.
Due
to
stability
in
exosomes,
exosomal
circRNAs
serve
as
biomarkers,
pathogenic
regulators
exert
therapeutic
potentials
some
cardiovascular
diseases,
atherosclerosis,
acute
coronary
syndrome,
ischemia/reperfusion
injury,
heart
failure,
peripheral
artery
disease.
In
this
review,
we
detailed
the
current
knowledge
on
biogenesis
functions
circRNAs,
well
their
involvement
these
providing
insights
into
diagnosis
treatment
diseases.
Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: Nov. 10, 2021
Exosomes
play
a
role
as
mediators
of
cell-to-cell
communication,
thus
exhibiting
pleiotropic
activities
to
homeostasis
regulation.
Exosomal
non-coding
RNAs
(ncRNAs),
mainly
microRNAs
(miRNAs),
long
(lncRNAs),
and
circular
(circRNAs),
are
closely
related
variety
biological
functional
aspects
human
health.
When
the
exosomal
ncRNAs
undergo
tissue-specific
changes
due
diverse
internal
or
external
disorders,
they
can
cause
tissue
dysfunction,
aging,
diseases.
In
this
review,
we
comprehensively
discuss
underlying
regulatory
mechanisms
exosomes
in
addition,
explore
current
knowledge
on
roles
miRNAs,
lncRNAs,
circRNAs
health
diseases,
including
cancers,
metabolic
neurodegenerative
cardiovascular
autoimmune
infectious
determine
their
potential
implication
biomarker
identification
therapeutic
exploration.
Theranostics,
Journal Year:
2021,
Volume and Issue:
11(19), P. 9376 - 9396
Published: Jan. 1, 2021
As
a
first-line
treatment
for
diabetes,
the
insulin-sensitizing
biguanide,
metformin,
regulates
glucose
levels
and
positively
affects
cardiovascular
function
in
patients
with
diabetes
complications.
Endothelial
dysfunction
(ED)
represents
primary
pathological
change
of
multiple
vascular
diseases,
because
it
causes
decreased
arterial
plasticity,
increased
resistance,
reduced
tissue
perfusion
atherosclerosis.
Caused
by
"biochemical
injury",
ED
is
also
an
independent
predictor
events.
Accumulating
evidence
shows
that
metformin
improves
through
liver
kinase
B1
(LKB1)/5'-adenosine
monophosphat-activated
protein
(AMPK)
AMPK-independent
targets,
including
nuclear
factor-kappa
B
(NF-κB),
phosphatidylinositol
3
kinase-protein
(PI3K-Akt),
endothelial
nitric
oxide
synthase
(eNOS),
sirtuin
1
(SIRT1),
forkhead
box
O1
(FOXO1),
krüppel-like
factor
4
(KLF4)
2
(KLF2).
Evaluating
effects
on
cell
functions
would
facilitate
our
understanding
therapeutic
potential
diabetology
(including
its
complications).
This
article
reviews
physiological
cells
intact
endothelium,
latest
research
related
complications,
focuses
mechanism
action
regulating
functions.
Frontiers in Bioscience-Landmark,
Journal Year:
2024,
Volume and Issue:
29(4)
Published: April 23, 2024
Atherosclerosis
(AS)
is
a
chronic
inflammatory
vascular
disease
that
begins
with
endothelial
activation
followed
by
series
of
responses,
plaque
formation,
and
finally
rupture.
An
early
event
in
dysfunction
the
nuclear
factor-κB
(NF-κB)
signaling
axis.
Toll-like
receptors
(TLRs)
cells
(ECs)
play
an
essential
role
recognizing
pathogen-associated
molecular
patterns
(PAMPs),
damage-associated
(DAMPs),
lifestyle-associated
(LAMPs).
Activation
canonical
NF-κB
pathway
stimulates
expression
cytokines,
chemokines,
array
additional
genes
which
activate
amplify
AS-associated
responses.
In
this
review,
we
discuss
involvement
TLR2/4
ECs
during
AS
initiation,
as
well
regulation
response
noncoding
RNAs,
especially
microRNA
(miRNA)
circular
RNA
(circRNA).
Journal of Advanced Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 1, 2024
Necroptosis
triggered
by
H2O2
is
hypothesized
to
be
a
critical
factor
in
the
rupture
of
atherosclerotic
plaques,
which
may
precipitate
acute
cardiovascular
events.
Nevertheless,
specific
regulatory
molecules
this
development
remain
unclear.
We
aims
elucidate
mechanism
from
perspective
circular
RNA.
There
are
few
studies
on
circRNA
VSMCs
necroptosis.
The
objective
our
research
shed
light
intricate
roles
that
circHIPK3
plays
process
necroptosis
and
plaques
prone
rupture.
Our
study
elucidates
molecular
mechanisms
regulates
vulnerable
plaque
formation
through
targeted
proteins.
Identifying
at
cellular
level
offers
framework
for
understanding
progression
stability
regulation,
as
well
potential
biomarker
prognosis
susceptible
plaques.
collected
clinical
vascular
tissue
HE
staining
Masson
determine
presence
Then,
NCBI
database
was
used
screen
out
with
elevated
expression
tissue,
up-regulated
circRNA,
circHIPK3,
verified
qRT-PCR
FISH.
Further,
we
synthesized
circHIPK3′s
small
interference
sequence
overexpressed
plasmid
vitro,
its
regulation
effect
under
physiological
pathological
conditions
WB,
PI
staining.
Through
RNA
pull
down,
mass
spectrometry
immunoprecipitation,
DRP1
identified
binding
protein
positively
regulated
circHIPK3.
Meanwhile,
basis
silencing
DRP1,
mediated
DRP1.
Finally,
validated
ApoE-/-
mice.
investigated
highly
expressed
increase
promoted
induced
VSMCs.
CircHIPK3
leading
an
elevation
mitochondrial
division
rate,
resulting
increased
reactive
oxygen
species
impaired
function,
ultimately
formation.
interact
involve
Mitochondrial
damage
VSMCs,
Silencing
vivo
can
reduce
findings
have
applications
providing
diagnostic
biomarkers
Frontiers in Oncology,
Journal Year:
2022,
Volume and Issue:
12
Published: April 28, 2022
As
a
novel
class
of
endogenous
non-coding
RNAs
discovered
in
recent
years,
circular
(circRNAs)
are
highly
conserved
and
stable
covalently
closed
ring
structures
with
no
5′-end
cap
or
3′-end
poly(A)
tail.
CircRNAs
formed
by
reverse
splicing,
mainly
means
noose
structure
intron
complementary
pairing.
Exosomes
tiny
discoid
vesicles
diameter
40-100
nm
that
secreted
cells
under
physiological
pathological
conditions.
play
an
important
role
cell-cell
communication
carrying
DNA,
microRNAs,
mRNAs,
proteins
circRNAs.
In
this
review,
we
summarize
the
biological
functions
circRNAs
exosomes,
further
reveal
potential
roles
exosomal
different
diseases,
providing
scientific
basis
for
diagnosis,
treatment,
prognosis
wide
variety
diseases.
Arteriosclerosis Thrombosis and Vascular Biology,
Journal Year:
2024,
Volume and Issue:
44(3)
Published: Jan. 18, 2024
IgE
has
been
known
for
mediating
endothelial
cell
dysfunction
and
mast
(MC)
activation
to
fuel
asthma-aggravated
high-fat
diet-induced
atherosclerosis.
However,
it
remains
unclear
the
mechanism
of
asthma-mediated
atherosclerosis,
especially
potential
involvement
in
exacerbation
atherosclerosis
with
a
standard
laboratory
diet,
cross
talk
between
cells
MCs.
Military Medical Research,
Journal Year:
2024,
Volume and Issue:
11(1)
Published: Sept. 26, 2024
Abstract
Nuclear
receptors
(NRs)
function
as
crucial
transcription
factors
in
orchestrating
essential
functions
within
the
realms
of
development,
host
defense,
and
homeostasis
body.
NRs
have
garnered
increased
attention
due
to
their
potential
therapeutic
targets,
with
drugs
directed
at
demonstrating
significant
efficacy
impeding
chronic
disease
progression.
Consequently,
these
pharmacological
agents
hold
promise
for
treatment
management
various
diseases.
Accumulating
evidence
emphasizes
regulatory
role
exosome-derived
microRNAs
(miRNAs)
inflammation,
progression,
therapy
resistance,
primarily
by
modulating
factors,
particularly
NRs.
By
exploiting
inflammatory
pathways
such
protein
kinase
B
(Akt)/mammalian
target
rapamycin
(mTOR),
nuclear
factor
kappa-B
(NF-κB),
signal
transducer
activator
3
(STAT3),
Wnt/β-catenin
signaling,
exosomes
play
a
pivotal
panorama
physiology,
pathology.
The
internalization
modulates
initiates
diverse
autocrine
or
paracrine
signaling
cascades,
influencing
processes
recipient
cells
survival,
proliferation,
differentiation,
metabolism,
cellular
defense
mechanisms.
This
comprehensive
review
meticulously
examines
involvement
exosome-mediated
NR
regulation
pathogenesis
ailments,
including
atherosclerosis,
cancer,
diabetes,
liver
diseases,
respiratory
conditions.
Additionally,
it
elucidates
molecular
intricacies
communication
between
via
NRs,
leading
immunomodulation.
Furthermore,
outlines
implications
exosome-modulated
prophylaxis
delineates
current
limitations,
provides
insights
into
future
perspectives.
also
presents
existing
on
components
emergence
resistance.
Pharmacological Research,
Journal Year:
2023,
Volume and Issue:
197, P. 106946 - 106946
Published: Oct. 4, 2023
Ocular
neovascular
disease
(OND),
characterized
by
the
aberrant
formation
of
immature
blood
vessels,
is
leading
cause
vision
impairment
and
blindness.
It
important
to
find
effective
ways
diagnose
treat
these
diseases.
Circular
RNA
(circRNA)
a
group
endogenous
non-coding
that
play
crucial
role
in
regulating
different
biological
processes.
Due
their
close
association
with
ocular
angiogenesis,
circRNAs
have
become
hotspot
OND
research.
In
this
review,
we
intensively
investigate
possibility
using
management
ONDs.
general,
angiogenesis
divided
into
five
phases.
On
basis
steps,
describe
potential
introducing
how
they
regulate
angiogenesis.
Subsequently,
interactions
between
ONDs,
including
pterygium,
corneal
neovascularization,
age-related
macular
degeneration,
diabetic
retinopathy,
retinopathy
prematurity,
are
analyzed
detail.
We
also
introduce
use
as
diagnostic
biomarkers.
Finally,
summarize
prospects
strategy
management.
The
gaps
recent
research
pointed
out
purpose
promoting
introduction
clinical
applications.
Biomolecules,
Journal Year:
2023,
Volume and Issue:
13(2), P. 214 - 214
Published: Jan. 22, 2023
Ischemic
stroke
is
among
the
leading
causes
of
morbidity,
disability,
and
mortality
worldwide.
Despite
recent
progress
in
management
acute
ischemic
stroke,
timely
intervention
still
represents
a
challenge.
Hence,
strategies
to
counteract
brain
injury
during
around
event
are
lacking,
also
due
limited
knowledge
underlying
mechanisms.
increasing
understanding
complex
pathophysiology
injury,
some
relevant
pieces
information
required,
particularly
regarding
fine
modulation
biological
processes.
In
this
context,
there
emerging
evidence
that
circular
RNAs,
class
highly
conserved
non-coding
RNA
with
closed-loop
structure,
involved
pathophysiological
processes
behind
unveiling
number
potential
therapeutic
targets
possible
clinical
biomarkers.
This
paper
aims
provide
comprehensive
overview
experimental
studies
on
role
RNAs
stroke.
