The potential role and mechanism of circRNA/miRNA axis in cholesterol synthesis

International Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 19(9), P. 2879 - 2896

Published: Jan. 1, 2023

Cholesterol levels are an initiating risk factor for atherosclerosis. Many genes play a central role in cholesterol synthesis, including HMGCR, SQLE, HMGCS1, FDFT1, LSS, MVK, PMK, MVD, FDPS, CYP51, TM7SF2, LBR, MSMO1, NSDHL, HSD17B7, DHCR24, EBP, SC5D, DHCR7, IDI1/2. Especially, and EBP promising therapeutic targets drug development due to many drugs have been approved entered into clinical research by targeting these genes. However, new still need be discovered. Interestingly, small nucleic acid vaccines were the market, Inclisiran, Patisiran, Inotersen, Givosiran, Lumasiran, Nusinersen, Volanesorsen, Eteplirsen, Golodirsen, Viltolarsen, Casimersen, Elasomeran, Tozinameran. agents all linear RNA agents. Circular RNAs (circRNAs) may longer half-lives, higher stability, lower immunogenicity, production costs, delivery efficiency than their covalently closed structures. CircRNA developed several companies, Orna Therapeutics, Laronde, CirCode, Therorna. studies shown that circRNAs regulate synthesis regulating ACS, YWHAG, PTEN, SREBP-2, PMK expression. MiRNAs essential circRNA-mediated biosynthesis. Notable, phase II trial inhibiting miR-122 with has completed. Suppressing circRNA_ABCA1, circ-PRKCH, circEZH2, circRNA-SCAP, circFOXO3 target development, specifically circFOXO3. This review focuses on mechanism of circRNA/miRNA axis hope providing knowledge identify targets.

Language: Английский

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Role of circular RNAs in disease progression and diagnosis of cancers: An overview of recent advanced insights

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 220, P. 973 - 984

Published: Aug. 14, 2022

Language: Английский

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Viral Circular RNAs and Their Possible Roles in Virus-Host Interaction

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: June 17, 2022

Circular RNAs (circRNAs) as novel regulatory molecules have been recognized in diverse species, including viruses. The virus-derived circRNAs play various roles the host biological process and life cycle of This review summarized from DNA RNA viruses discussed biogenesis viral circRNAs, potential their future perspective. will elaborate on new insights gained encoded during virus infection.

Language: Английский

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The Role of Circular RNA for Early Diagnosis and Improved Management of Patients with Cardiovascular Diseases

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2986 - 2986

Published: March 4, 2024

Cardiovascular diseases (CVDs) are responsible for approximately 17.9 million deaths every year. There is growing evidence that circular RNAs (circRNAs) may play a significant role in the early diagnosis and treatment of cardiovascular diseases. As regulatory molecules, regulate gene expression, interact with proteins miRNAs, translated into key wide variety biological processes, including division proliferation cells, as well growth development individuals. An overview properties, expression profiles, classification, functions circRNAs presented here, along an explanation their implications heart failure, hypertension, ischemia/reperfusion injury, myocardial infarction, cardiomyopathies, atherosclerosis, arrhythmia.

Language: Английский

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Non-Coding RNAs in Regulating Plaque Progression and Remodeling of Extracellular Matrix in Atherosclerosis

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(22), P. 13731 - 13731

Published: Nov. 8, 2022

Non-coding RNAs (ncRNAs) regulate cell proliferation, migration, differentiation, inflammation, metabolism of clinically important biomolecules, and other cellular processes. They do not encode proteins but are involved in the regulatory network various that directly related to pathogenesis diseases. Little is known about ncRNA-associated mechanisms atherosclerosis cardiovascular disorders. Remodeling extracellular matrix (ECM) critical disorders; however, its potential subjects explore with special emphasis on epigenetic components. The activity ECM remodeling regulated by ncRNA molecules, as evident from recent research. Thus, it critically evaluate existing literature enhance understanding nc-RNAs-regulated molecular regulating components, remodeling, progression atherosclerosis. This crucial since deregulated contributes an in-depth may identify novel targets for treatment

Language: Английский

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A review on circular RNAs and bacterial infections

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 244, P. 125391 - 125391

Published: June 15, 2023

Language: Английский

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The potential role and mechanism of circRNAs in foam cell formation

Non-coding RNA Research, Journal Year: 2023, Volume and Issue: 8(3), P. 315 - 325

Published: March 21, 2023

Atherosclerosis is a significant risk factor for coronary heart disease (CHD) and myocardial infarction (MI). develops during foam cell generation, which caused by an imbalance in cholesterol uptake, esterification, efflux. LOX-1, SR-A1, CD36 all increased uptake. ACAT1 ACAT2 promote free (FC) esterification to cholesteryl esters (CE). The hydrolysis of CE FC was aided nCEH. efflux promoted ABCA1, ABCG1, ADAM10, apoA-I. SR-BI promotes not only uptake but also Circular RNAs (circRNAs), are single-stranded with closed covalent circular structure, have emerged as promising biomarkers therapeutic targets atherosclerosis due their highly tissue, cell, state-specific expression profiles. Numerous studies shown that circRNAs regulate formation, acting miRNA sponges influence development regulating the CD36, ACAT2, apoA-I, SR-B1. Several circRNAs, including circ-Wdr91, circ 0004104, circRNA0044073, circRNA_0001805, circDENND1B, circRSF1, 0001445, circRNA 102682, potential better evaluate cardiovascular risk. It difficult deliver synthetic desired target tissues. Nanotechnology, such GA-RM/GZ/PL, may be important solution this problem. In review, we focus on role mechanism circRNA/miRNA axis formation hopes discovering new diagnosis, prevention, treatment atherosclerosis.

Language: Английский

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Exploratory Review and In Silico Insights into circRNA and RNA-Binding Protein Roles in γ-Globin to β-Globin Switching

Cells, Journal Year: 2025, Volume and Issue: 14(4), P. 312 - 312

Published: Feb. 19, 2025

β-globin gene cluster regulation involves complex mechanisms to ensure proper expression and function in RBCs. During development, switching occurs as γ-globin is replaced by β-globin. Key regulators, like BCL11A ZBTB7A, repress facilitate this transition with other factors, KLF1, LSD1, PGC-1α; these regulators an orchestrated from γ- during development. While have been extensively studied, circRNAs recently emerged key contributors regulation, but their role remains largely unexplored. Although discovered the 1970s, only recognized for functional roles, particularly interactions RNA-binding proteins. Understanding how contribute could lead new therapeutic strategies hemoglobinopathies, such sickle cell disease β-thalassemia. This review uses circAtlas 3.0 database explore circRNA expressions genes related expression, focusing on blood, bone marrow, liver, spleen. It emphasizes exploration of potential between proteins involved regulatory mechanisms, further enhancing our understanding expression.

Language: Английский

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Circular RNA circ_0029589 promotes ox-LDL-induced endothelial cell injury through regulating RAB22A by serving as a sponge of miR-1197

Clinical Hemorheology and Microcirculation, Journal Year: 2023, Volume and Issue: 83(4), P. 359 - 376

Published: Jan. 20, 2023

Dysfunction of endothelial cells is now considered a vital contributor to the pathogenesis atherosclerosis (AS). Moreover, circular RNA (circRNA) circ_0029589 has been found be involved in regulation oxidized low-density lipoprotein (ox-LDL)-induced cell damage. Nevertheless, its molecular mechanism ox-LDL-triggered injury poorly defined.Human umbilical vein (HUVECs) treated with ox-LDL were applied as models AS. Circ_0029589, microRNA-1197 (miR-1197), and Ras-related protein Rab-22A (RAB22A) expression detected using real-time quantitative polymerase chain reaction (RT-qPCR). Cell proliferation, apoptosis, angiogenesis, invasion 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2-H-tetrazolium bromide (MTT), 5-ethynyl-2'-deoxyuridine (EdU), flow cytometry, tube formation, transwell assays. Western blot analysis Cleaved-caspase-3, B-cell lymphoma-2 related X (Bax), RAB22A. IL-6, IL-1β, Tumor necrosis factor α (TNF-α) levels gauged ELISA kits. Superoxide Dismutase (SOD) activity Malondiahyde (MDA) level assessed special Bioinformatics software predicted binding between miR-1197 or RAB22A, which was proved dual-luciferase reporter pull-down assays.Circ_0029589 RAB22A strengthened, reduced ox-LDL-treated HUVECs. Importantly, silencing ameliorated HUVEC damage via promoting formation ability, invasion, repressing inflammation, oxidative stress. Mechanical suggested that might affect content through sponging miR-1197.Circ_0090231 protect against ox-LDL-mediated miR-1197/RAB22A axis, provides therapeutic strategy for

Language: Английский

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The Emerging Role of CircRNAs in Atherosclerosis

Current Vascular Pharmacology, Journal Year: 2023, Volume and Issue: 21(1), P. 26 - 41

Published: Jan. 1, 2023

Abstract: Cardiovascular diseases (CVDs) based on atherosclerosis remain the main reason for death in Western countries and China. research has demonstrated that its pathogenesis is closely associated with endothelial cell (EC) injury, phenotypic transformation of vascular smooth muscle cells (VSMCs), abnormal biological behaviour macrophages. In recent years, circular RNAs (circRNAs) have received much attention their unique role atherosclerosis. this review, we discussed mechanisms ECs, VSMCs, macrophages summarized circRNAs This review aims to provide a basis prevention treatment

Language: Английский

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