Alleviation of D-gal-induced senile liver injury by Rg3, a signature component of red ginseng DOI Creative Commons
Ke Xu,

Biwen Hu,

Xuhui Ding

et al.

Aging, Journal Year: 2023, Volume and Issue: 15(14), P. 6749 - 6756

Published: June 21, 2023

To investigate the mechanism by which ginsenoside Rg3 regulates oxidative stress (OS) and inflammation through NF/KB pathway to delay mouse liver injury. This work randomized Balbc mice as four groups: Normal, D-gal, Rg3-L, Rg3-H. Paraffin-embedded tissue sections were prepared, later, BAX/BCL-2 protein expression was observed HE, Sirius red, TUNEL immunofluorescence detect apoptotic injury α-SMA/TGF-β fibrosis, inflammation-related NF-KB detected. HE staining showed that reduced necrotic cells fibrosis in liver-injured mice, increased anti-inflammatory cytokine IL-18 TNF-α, IL-1β IL-6 expression. Conclusion: Ginsenoside can effectively antagonize D-gal's role injury, its may be associated with regulating inflammatory Rg.

Language: Английский

Fu-Zheng-Tong-Luo formula promotes autophagy and alleviates idiopathic pulmonary fibrosis by controlling the Janus kinase 2/signal transducer and activator of transcription 3 pathway DOI
Xing Zhang, Jie Su, Jiacheng Lin

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 314, P. 116633 - 116633

Published: May 17, 2023

Language: Английский

Citations

5
New perspective on the immunomodulatory activity of ginsenosides: Focus on effective therapies for post-COVID-19 DOI Creative Commons
Yixin Wang, Qin Han, Shuxia Zhang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115154 - 115154

Published: July 14, 2023

More than 700 million confirmed cases of Coronavirus Disease-2019 (COVID-19) have been reported globally, and 10–60% patients are expected to exhibit "post-COVID-19 symptoms," which will continue affect human life health. In the absence safer, more specific drugs, current multiple immunotherapies failed achieve satisfactory efficacy. Ginseng, a traditional Chinese medicine, is often used as an immunomodulator has in COVID-19 treatment tonic increase blood oxygen saturation. Ginsenosides main active components ginseng. this review, we summarize ways ginsenosides post-COVID-19 symptoms, including inhibition lipopolysaccharide, tumor necrosis factor signaling, modulation chemokine receptors inflammasome activation, induction macrophage polarization, effects on Toll-like receptors, nuclear kappa-B, mitogen-activated protein kinase pathway, lymphocytes, intestinal flora, epigenetic regulation. virus-mediated tissue damage, local or systemic inflammation, immune modulation, other links, thus alleviating respiratory pulmonary reducing cardiac burden, protecting nervous system, providing new ideas for rehabilitation with symptoms. Furthermore, analyzed its role strengthening body resistance eliminate pathogenic factors from perspective ginseng-epidemic disease highlighted challenges clinical applications. However, benefit modulating organismal imbalance needs be further evaluated better validate pharmacological mechanisms associated their efficacy determine individualized therapy.

Language: Английский

Citations

5
Ginsenoside Rg1 Alleviates Lipopolysaccharide-Induced Fibrosis of Endometrial Epithelial Cells in Dairy Cows by Inhibiting Reactive Oxygen Species-Activated NLRP3 DOI Creative Commons
Liangli Song, Linnan Wang, Xiangchen Li

et al.

Animals, Journal Year: 2023, Volume and Issue: 13(23), P. 3723 - 3723

Published: Dec. 1, 2023

Abnormal function and the fibrosis of endometrium caused by endometritis in cows may lead to difficult embryo implantation uterine cavity adhesions. Emerging evidence indicates that ginsenoside Rg1 can effectively resist inflammation pathological different organs. It is hypothesized possess potential mitigate endometrial induced lipopolysaccharides (LPS) dairy cows. Herein, a model LPS-stimulated was constructed using bovine epithelial cell line (BEND) cells ICR mice. Western blotting used detect protein level, reactive oxygen species (ROS) content measured means DCFH-DA. The tissue structure stained with H&E Masson staining. murine assessed for oxidative stress detecting concentration MDA together activity enzymatic antioxidants SOD CAT. Ginsenoside interfered NLRP3 activation reducing ROS generation. After application inhibitor NAC MCC950, could interfere ROS/NLRP3 inflammasome signaling pathway suppressing epithelial-mesenchymal transition (EMT) BEND cells. Our vivo data showed relieved mouse LPS-induced restraining pathway. inhibits EMT progression probably inhibiting ROS-NLRP3 inflammasome.

Language: Английский

Citations

5
Hepato- and reno-protective effects of thymoquinone, crocin, and carvacrol: A comprehensive review DOI Creative Commons
Akbar Anaeigoudari

Asian Pacific Journal of Tropical Biomedicine, Journal Year: 2022, Volume and Issue: 12(5), P. 185 - 196

Published: May 1, 2022

Medicinal plants are rich in nutrients and phytochemicals which prevent treat a wide range of ailments. Accumulating experimental studies exhibit that some bioactive ingredients extracted from medicinal have suitable therapeutic effects on hepatic renal injuries. This review focuses the hepato- reno-protective thymoquinone, crocin, carvacrol. The relevant literature was retrieved PubMed, Scopus, Web Science, Google Scholar databases beginning 2015 until end November 2021. According to scientific evidence, considered this been applied with useful damage. These were mainly mediated through amelioration oxidative stress, suppression inflammatory responses, inhibition apoptosis. Intracellular signaling pathways linked nuclear factor kappa B (NF-κB), adenosine monophosphate-activated protein kinase, c-jun N-terminal extracellular signal-regulated kinase 1/2 Toll-like receptors most important targeted by these phytochemicals. Up-regulation transcription Nrf2 down-regulation transforming growth factor-beta 1 natural compounds also contribute alleviation

Language: Английский

Citations

8
Alleviation of D-gal-induced senile liver injury by Rg3, a signature component of red ginseng DOI Creative Commons
Ke Xu,

Biwen Hu,

Xuhui Ding

et al.

Aging, Journal Year: 2023, Volume and Issue: 15(14), P. 6749 - 6756

Published: June 21, 2023

To investigate the mechanism by which ginsenoside Rg3 regulates oxidative stress (OS) and inflammation through NF/KB pathway to delay mouse liver injury. This work randomized Balbc mice as four groups: Normal, D-gal, Rg3-L, Rg3-H. Paraffin-embedded tissue sections were prepared, later, BAX/BCL-2 protein expression was observed HE, Sirius red, TUNEL immunofluorescence detect apoptotic injury α-SMA/TGF-β fibrosis, inflammation-related NF-KB detected. HE staining showed that reduced necrotic cells fibrosis in liver-injured mice, increased anti-inflammatory cytokine IL-18 TNF-α, IL-1β IL-6 expression. Conclusion: Ginsenoside can effectively antagonize D-gal's role injury, its may be associated with regulating inflammatory Rg.

Language: Английский

Citations

4