The Mechanism by Which Estrogen Level Affects Knee Osteoarthritis Pain in Perimenopause and Non-Pharmacological Measures

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2391 - 2391

Published: March 7, 2025

Perimenopausal women have fluctuating estrogen levels, which often trigger a range of symptoms perimenopausal syndromes as levels decrease. Changes in are closely related to pain knee osteoarthritis (KOA), has long been research area great interest women. In recent years, it found that an important role KOA pain, namely, can affect through the regulation inflammatory responses, inhibition cellular senescence and apoptosis, modulation neurotransmitters, may provide new ideas for treatment. This study aims describe mechanism level on perimenopause non-pharmacological measures, such physical therapy, factor traditional Chinese medicine, diet, reference treatment with KOA.

Language: Английский

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Exploration of the Potential and Mechanisms of Diabetic Cognitive Disorder Modulation by Daehwangmokdanpi-tang through a Network Pharmacological Approach

Journal of Korean Medicine, Journal Year: 2024, Volume and Issue: 45(2), P. 23 - 40

Published: June 1, 2024

Objectives: This study utilized a network pharmacology approach to investigate the potential therapeutic effects and underlying mechanisms of Daehwangmokdanpi-tang (DHMDPT) in diabetic cognitive disorder (DCD).Methods: The compounds DHMDPT their target genes were obtained from OASIS PubChem databases. These putative compared with known targets DCD identify correlations. Using Cytoscape 3.10.2, was constructed highlight key genes. To further elucidate mechanisms, functional enrichment analysis performed using Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathways. Finally, CB-DOCK used assess binding affinities confirm interactions.Results: results showed that total 27 439 related identified DHMDPT. Among these, 373 interacted gene set, indicating close relationship between DCD. Through GO KEGG pathways, ‘Regulation Apoptotic Process’, ‘Cytokine-Mediated signaling pathway’, ‘AGE-RAGE pathway complications’ as pathways 18 on Additionally, molecular docking six most highly associated active compounds.Conclusions: approach, which included docking, found be relevant could serve foundation for research enhancement

Language: Английский

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CDR1as Deficiency Prevents Photoreceptor Degeneration by Regulating miR-7a-5p/α-syn/Parthanatos Pathway in Retinal Detachment

American Journal Of Pathology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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Clinical efficacy of mesenchymal stem cells and platelet-rich plasma in the therapy of osteoarthritis: a meta-analysis

American Journal of Translational Research, Journal Year: 2024, Volume and Issue: 16(9), P. 4256 - 4267

Published: Jan. 1, 2024

Intra-articular administration of mesenchymal stem cells (MSCs) presents a novel methodology for managing osteoarthritis, but there is still no definite evidence its efficacy.

Language: Английский

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