Experimental Cell Research, Journal Year: 2024, Volume and Issue: 444(1), P. 114359 - 114359
Published: Nov. 26, 2024
Language: Английский
Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)
Published: Nov. 29, 2024
Abstract Tumor energy metabolism plays a crucial role in the occurrence, progression, and drug resistance of tumors. The study tumor has gradually become an emerging field treatment. Recent studies have shown that epigenetic regulation is closely linked to metabolism, influencing metabolic remodeling biological traits cells. This review focuses on primary pathways explores therapeutic strategies target these pathways. It covers key areas such as glycolysis, Warburg effect, mitochondrial function, oxidative phosphorylation, adaptability Additionally, this article examines regulator SWI/SNF complex specifically its interactions with glucose, lipids, amino acids. Summarizing aimed at pathways, including inhibitors mitochondrial-targeted drugs, exploitation vulnerabilities, recent developments related complexes potential targets. clinical significance, challenges, future directions research are discussed, overcome resistance, combination therapy, application new technologies.
Language: Английский
Citations
7
Published: Jan. 1, 2025
Cellular long noncoding RNAs (lncRNAs) have been shown to participate in diverse biological pathways, including the regulation of virus infections. However, their functions hepatitis B (HBV) life cycle still need be explored. Here, we conducted a loss-of-function screen targeting 1779 human lncRNAs and identified 19 associated with HBV infection. One lncRNA, named MAPKAPK5-AS1 (lnc-MAAS), was as host factor required for Our data suggest that lnc-MAAS is involved conversion relaxed circular DNA into covalently closed (cccDNA). Furthermore, mechanistic experiments revealed affects cccDNA formation by modulating expression nucleic acid binding protein 1 (NABP1). Together, our findings shed light on roles NABP1 formation, which may contribute development novel anti-HBV therapeutics.
Language: Английский
Citations
0
Immunometabolism, Journal Year: 2025, Volume and Issue: 7(1), P. e00054 - e00054
Published: Jan. 1, 2025
The oral epithelium, a dynamic interface constantly facing environmental challenges, relies on intricate molecular pathways to maintain its homeostasis. This comprehensive review delves into the nuanced interplay between T-lymphocytic cells (T cells) and RNA-binding proteins (RBPs) within elucidating their roles in orchestrating immune responses influencing tissue plasticity. By synthesizing current knowledge, we aim unravel intricacies that govern this interplay, with focus potential therapeutic implications for health diseases. Understanding regulatory networks shaped by T RBPs epithelial microenvironment holds promise innovative strategies managing conditions associated dysfunction.
Language: Английский
Citations
0
Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)
Published: Oct. 25, 2023
Long non-coding RNA (lncRNA) HOTAIR acts importantly in liver cancer development, but its effect on radioresistance remains poorly understood. Here, our study probed into the possible impact of stem cells (LCSCs) and to elucidate molecular basis.Following sorting non-stem cells, LCSCs were identified subjected RNA-seq analysis for selecting differentially expressed genes. Expression was determined tissues CSCs. The stemness, proliferation, apoptosis then detected response altered expression HOTAIR-LSD1-JMJD6-BRD4.Ectopic found promote by maintaining stemness. Mechanistic investigations indicated that recruited LSD1 MAPK1 promoter region reduced level H3K9me2 region, thus elevating ERK2 (MAPK1) expression. JMJD6-BRD4 complex promoted transcription forming a positively regulated expression, stemness LCSCs, ultimately promoting their vitro vivo.Collectively, work highlights through HOTAIR-dependent mechanism.
Language: Английский
Citations
9
Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(2)
Published: Feb. 7, 2024
Abstract Long noncoding RNAs (lncRNAs) are major components of cellular transcripts that emerging as important players in various biological pathways. Due to their specific expression and functional diversity a variety cancers, lncRNAs have promising applications cancer diagnosis, prognosis, therapy. Studies shown lncRNA DiGeorge syndrome critical region gene 5 (DGCR5) with high specificity accuracy has the potential become biomarkers cancers. LncRNA DGCR5 can be noninvasively extracted from body fluids, tissues, cells, used independent or auxiliary improve diagnosis prognosis. Now, underlying mechanisms such were explored therapeutic targets, which been investigated clinical trials several The lacks an appropriate animal model, is necessary gain greater knowledge functions. While some studies on uses carried out, small sample size makes them unreliable. In this review, we presented compilation recent publications addressing could considered hopes providing promised implications for future
Language: Английский
Citations
1
European Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 262, P. 115875 - 115875
Published: Oct. 17, 2023
Language: Английский
Citations
3
Immunologic Research, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 17, 2024
Language: Английский
Citations
0
Experimental Cell Research, Journal Year: 2024, Volume and Issue: 444(1), P. 114359 - 114359
Published: Nov. 26, 2024
Language: Английский
Citations
0