LncRNA CRNDE and HOTAIR; Molecules Behind the Scenes in the Progression of Gastrointestinal Cancers through Regulating microRNAs DOI
Mohamed J. Saadh, Soumya V. Menon, Rajni Verma

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 266, P. 155778 - 155778

Published: Dec. 17, 2024

Language: Английский

Molecular insights into regulatory RNAs in the cellular machinery DOI Creative Commons
Sumin Yang, Sung-Hyun Kim, Eun-Jeong Yang

et al.

Experimental & Molecular Medicine, Journal Year: 2024, Volume and Issue: 56(6), P. 1235 - 1249

Published: June 14, 2024

It is apparent that various functional units within the cellular machinery are derived from RNAs. The evolution of sequencing techniques has resulted in significant insights into approaches for transcriptome studies. Organisms utilize RNA to govern systems, and a heterogeneous class RNAs involved regulatory functions. In particular, increasingly recognized participate intricately functioning across almost all levels biological systems. These systems include those mediating chromatin arrangement, transcription, suborganelle stabilization, posttranscriptional modifications. Any exhibiting activity can be termed typically represented by noncoding RNAs, which constitute substantial portion genome. function based on principle structural changes through cis and/or trans regulation facilitate mutual RNA‒RNA, RNA‒DNA, RNA‒protein interactions. not been clearly elucidated whether identified deep actually anticipated mechanisms. This review addresses dominant properties at layers covers activities, dynamics, modifications, associated molecules, further challenges related therapeutics learning.

Language: Английский

Citations

9
Long Non-Coding RNAs: Key Regulators of Tumor Epithelial/Mesenchymal Plasticity and Cancer Stemness DOI Creative Commons
Yuan Yuan,

Yun Tang,

Zeng Fang

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(3), P. 227 - 227

Published: Feb. 5, 2025

Long non-coding RNAs (lncRNAs) are a class of RNA molecules with transcripts longer than 200 bp, which were initially thought to be noise from genomic transcription without biological function. However, since the discovery H19 in 1980 and Xist 1990, increasing evidence has shown that lncRNAs regulate gene expression at epigenetic, transcriptional, post-transcriptional levels through specific regulatory actions involved development cancer other diseases. Despite many being expressed lower those protein-coding genes less sequence conservation across species, have become an intense area research. They exert diverse functions such as inducing chromatin remodeling, recruiting transcriptional machinery, acting competitive endogenous for microRNAs, modulating protein–protein interactions. Epithelial–mesenchymal transition (EMT) is developmental process, associated embryonic development, wound healing, progression. In context oncogenesis, EMT program transiently activated confers migratory/invasive stem cell (CSC) properties tumor cells, crucial malignant progression, metastasis, therapeutic resistance. Accumulating revealed play roles regulation epithelial/mesenchymal plasticity (EMP) stemness. Here, we summarize emerging molecular mechanisms regulating EMP their effects on initiation progression CSCs. We also discuss potential diagnostic prognostic biomarkers targets.

Language: Английский

Citations

1
The role of HOTAIR in the modulation of resistance to anticancer therapy DOI Creative Commons
Monica Cantile, Valentina Belli, Giosuè Scognamiglio

et al.

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11

Published: June 3, 2024

Leading anti-tumour therapeutic strategies typically involve surgery and radiotherapy for locally advanced (non-metastatic) cancers, while hormone therapy, chemotherapy, molecular targeted therapy are the current treatment options metastatic cancer. Despite initially high sensitivity rate to anticancer therapies, a large number of patients develop resistance, leading poor prognosis. The mechanisms related drug resistance highly complex, long non-coding RNAs appear play crucial role in these processes. Among these, lncRNA homeobox transcript antisense intergenic RNA (HOTAIR), widely implicated cancer initiation progression, likewise plays significant resistance. It can modulate cell activities such as proliferation, apoptosis, hypoxia, autophagy, well epithelial-mesenchymal transition, thereby contributing development resistant tumour cells. In this manuscript, we describe different antitumor which HOTAIR is involved suggest its potential predictive biomarker management patients.

Language: Английский

Citations

5
JMJD6 K375 acetylation restrains lung cancer progression by enhancing METTL14/m6A/SLC3A2 axis mediated cell ferroptosis DOI Creative Commons

Huanxiang Chen,

Nan Xiao,

Chenxing Zhang

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 26, 2025

Language: Английский

Citations

0
A review of molecular interplay between inflammation and cancer: The role of lncRNAs in pathogenesis and therapeutic potential DOI
Yan Yang, Chuxi Zhang,

H C Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142824 - 142824

Published: April 1, 2025

Language: Английский

Citations

0
A HOTAIR-associated super-enhancer orchestrates glioblastoma malignancy via MEST DOI Creative Commons
Peng Li, Yang Yang, Chunyan Luan

et al.

Oncogenesis, Journal Year: 2025, Volume and Issue: 14(1)

Published: April 7, 2025

Language: Английский

Citations

0
Pathological roles of lncRNA HOTAIR in liver cancer: An updated review DOI
Chou‐Yi Hsu, Azfar Jamal, Mohammad Azhar Kamal

et al.

Gene, Journal Year: 2024, Volume and Issue: 940, P. 149180 - 149180

Published: Dec. 19, 2024

Language: Английский

Citations

2
Research Progress on the Role of JMJD6 Molecule in Tumorigenesis and Tumor Development DOI

宏鑫 张

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(10), P. 1120 - 1129

Published: Jan. 1, 2024

Language: Английский

Citations

0
LncRNA CRNDE and HOTAIR; Molecules Behind the Scenes in the Progression of Gastrointestinal Cancers through Regulating microRNAs DOI
Mohamed J. Saadh, Soumya V. Menon, Rajni Verma

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 266, P. 155778 - 155778

Published: Dec. 17, 2024

Language: Английский

Citations

0