Journal of Biosciences and Medicines,
Journal Year:
2023,
Volume and Issue:
11(10), P. 241 - 254
Published: Jan. 1, 2023
Esophageal
squamous
cell
carcinoma
(ESCC),
as
the
main
histological
type
of
esophageal
cancer
(EC),
has
characteristics
high
malignant
degree,
mortality
and
tendency
to
lymph
node
metastasis.
Despite
combination
surgery
chemoradiotherapy,
ECSS
a
poor
prognosis.
Ferroptosis
is
newly
discovered
iron-dependent
programmed
death
pattern
characterized
by
accumulation
lipid
peroxidation
characteristic
morphological
changes
mitochondria.
It
regulates
growth
invasion
cells
in
various
tumors
such
gastric
pancreatic
cancer.
In
this
article,
we
mainly
introduce
ferroptosis
regulatory
mechanism
ESCC,
hoping
provide
new
direction
ideas
for
treatment
ECSS.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: March 8, 2024
Ferroptosis
is
a
non-apoptotic
form
of
regulated
cell
death
characterized
by
the
lethal
accumulation
iron-dependent
membrane-localized
lipid
peroxides.
It
acts
as
an
innate
tumor
suppressor
mechanism
and
participates
in
biological
processes
tumors.
Intriguingly,
mesenchymal
dedifferentiated
cancer
cells,
which
are
usually
resistant
to
apoptosis
traditional
therapies,
exquisitely
vulnerable
ferroptosis,
further
underscoring
its
potential
treatment
approach
for
cancers,
especially
refractory
cancers.
However,
impact
ferroptosis
on
extends
beyond
direct
cytotoxic
effect
cells.
induction
not
only
inhibits
but
also
promotes
development
due
negative
anticancer
immunity.
Thus,
comprehensive
understanding
role
crucial
successful
translation
therapy
from
laboratory
clinical
applications.
In
this
review,
we
provide
overview
recent
advancements
cancer,
covering
molecular
mechanisms,
functions,
regulatory
pathways,
interactions
with
microenvironment.
We
summarize
applications
immunotherapy,
radiotherapy,
systemic
therapy,
well
inhibition
various
conditions.
finally
discuss
markers,
current
challenges
future
directions
cancer.
Autophagy,
Journal Year:
2024,
Volume and Issue:
20(6), P. 1213 - 1246
Published: March 6, 2024
Macroautophagy/autophagy
is
a
complex
degradation
process
with
dual
role
in
cell
death
that
influenced
by
the
types
are
involved
and
stressors
they
exposed
to.
Ferroptosis
an
iron-dependent
oxidative
form
of
characterized
unrestricted
lipid
peroxidation
context
heterogeneous
plastic
mechanisms.
Recent
studies
have
shed
light
on
involvement
specific
autophagy
(e.g.
ferritinophagy,
lipophagy,
clockophagy)
initiating
or
executing
ferroptotic
through
selective
anti-injury
proteins
organelles.
Conversely,
other
forms
reticulophagy
lysophagy)
enhance
cellular
defense
against
damage.
Dysregulated
autophagy-dependent
ferroptosis
has
implications
for
diverse
range
pathological
conditions.
This
review
aims
to
present
updated
definition
ferroptosis,
discuss
influential
substrates
receptors,
outline
experimental
methods,
propose
guidelines
interpreting
results.
Hepatology,
Journal Year:
2023,
Volume and Issue:
80(3), P. 721 - 739
Published: April 4, 2023
The
most
widespread
type
of
liver
cancer,
HCC,
is
associated
with
disabled
cellular
death
pathways.
Despite
therapeutic
advancements,
resistance
to
current
systemic
treatments
(including
sorafenib)
compromises
the
prognosis
patients
driving
search
for
agents
that
might
target
novel
cell
Ferroptosis,
a
form
iron-mediated
nonapoptotic
death,
has
gained
considerable
attention
as
potential
cancer
therapy,
especially
in
HCC.
role
ferroptosis
HCC
complex
and
diverse.
On
one
hand,
can
contribute
progression
through
its
involvement
both
acute
chronic
conditions.
In
contrast,
having
affect
cells
be
desirable.
This
review
examines
from
cellular,
animal,
human
perspectives
while
examining
mechanisms,
regulation,
biomarkers,
clinical
implications.
Neurochemical Research,
Journal Year:
2024,
Volume and Issue:
49(8), P. 1965 - 1979
Published: June 4, 2024
Abstract
Cerebral
ischemia–reperfusion
injury
(CIRI)
is
the
second
leading
cause
of
death
worldwide,
posing
a
huge
risk
to
human
life
and
health.
Therefore,
investigating
pathogenesis
underlying
CIRI
developing
effective
treatments
are
essential.
Ferroptosis
an
iron-dependent
mode
cell
death,
which
caused
by
disorders
in
iron
metabolism
lipid
peroxidation.
Previous
studies
demonstrated
that
ferroptosis
also
form
autophagic
nuclear
receptor
coactivator
4(NCOA4)
mediated
ferritinophagy
was
found
regulate
interfering
with
metabolism.
Ferritinophagy
important
pathogenic
mechanisms
CIRI.
This
review
mainly
summarizes
link
regulation
between
further
discusses
their
In
addition,
potential
treatment
methods
targeting
for
presented,
providing
new
ideas
prevention
clinical
future.
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
13
Published: Feb. 25, 2025
Ferritinophagy,
the
selective
autophagic
degradation
of
ferritin
to
release
iron,
is
emerging
as
a
critical
regulator
iron
homeostasis
and
key
player
in
pathogenesis
various
liver
diseases.
This
review
comprehensively
examines
mechanisms,
regulation,
multifaceted
roles
ferritinophagy
health
disease.
Ferritinophagy
intricately
regulated
by
several
factors,
including
Nuclear
Receptor
Coactivator
4
(NCOA4),
Iron
regulatory
proteins
signaling
pathways
such
mTOR
AMPK.
These
mechanisms
ensure
proper
utilization
prevent
overload,
which
can
induce
oxidative
stress
ferroptosis.
In
diseases,
exhibits
dual
roles.
fibrosis,
promoting
hepatic
stellate
cells
(HSCs)
cell
senescence
reduce
fibrosis
progression.
However,
non-alcoholic
fatty
disease
(NAFLD),
chronic
may
exacerbate
injury
through
overload
stress.
hepatocellular
carcinoma
(HCC),
be
harnessed
novel
therapeutic
strategy
inducing
ferroptosis
cancer
cells.
Additionally,
implicated
drug-induced
sepsis-associated
damage,
highlighting
its
broad
impact
on
pathology.
also
explores
crosstalk
between
other
autophagy
pathways,
mitophagy
lipophagy,
collectively
influence
cellular
Understanding
these
interactions
essential
for
developing
comprehensive
strategies
targeting
multiple
pathways.
summary,
complex
dynamic
process
with
significant
implications
provides
an
in-depth
analysis
ferritinophagy's
potential
target,
emphasizing
need
further
research
elucidate
role
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
170, P. 116074 - 116074
Published: Dec. 25, 2023
Hepatocellular
carcinoma
(HCC)
remains
a
major
global
health
burden,
and
sorafenib,
multi-kinase
inhibitor,
has
shown
effectiveness
in
the
treatment
of
HCC
is
considered
as
first-line
therapy
for
advanced
HCC.
However,
response
to
sorafenib
varies
among
patients,
development
drug
resistance
poses
prevalent
obstacle.
Ferroptosis,
newly
characterized
form
cell
death
featured
by
iron-dependent
lipid
peroxidation,
emerged
critical
player
reaction
The
induction
ferroptosis
been
augment
anticancer
benefits
sorafenib.
it
also
observed
contribute
resistance.
This
review
presents
comprehensive
thorough
analysis
that
elucidates
intricate
relationship
between
over
recent
years,
aiming
formulate
effective
therapeutic
approaches
liver
cancer.
Based
on
this
exploration,
we
propose
innovative
strategies
intended
overcome
via
targeted
modulation
ferroptosis.
