2023 Clinical Practice Guidelines for Diabetes Management in Korea: Full Version Recommendation of the Korean Diabetes Association

Diabetes & Metabolism Journal, Journal Year: 2024, Volume and Issue: 48(4), P. 546 - 708

Published: July 29, 2024

Language: Английский

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Prevalence, Awareness, Treatment, and Control of Type 2 Diabetes in South Korea (1998 to 2022): Nationwide Cross-Sectional Study

JMIR Public Health and Surveillance, Journal Year: 2024, Volume and Issue: 10, P. e59571 - e59571

Published: Aug. 27, 2024

Background Type 2 diabetes poses an increasing disease burden in South Korea. The development and management of type are closely related to lifestyle socioeconomic factors, which have undergone substantial changes over the past few decades, including during COVID-19 pandemic. Objective This study aimed investigate long-term trends prevalence, awareness, treatment, control. It also determine whether there were alterations pandemic these more pronounced within specific demographic groups. Methods examined control a representative sample 139,786 Koreans aged >30 years, using data from National Health Nutrition Examination Survey covering period 1998 2022. Weighted linear regression binary logistic performed calculate weighted β coefficients or odds ratios. Stratified analyses based on sex, age, region residence, obesity status, educational background, household income, smoking status. (difference) was calculated analyze trend difference between prepandemic To identify groups susceptible diabetes, we estimated interaction terms for each factor Results From 2022, consistent increase prevalence observed among Koreans, with notable rise 15.61% (95% CI 14.83-16.38) Awareness followed U-shaped curve, bottoming out at 64.37% 61.79-66.96) 2013 2015 before 72.56% 70.39-74.72) Treatment increased time, peaking 68.33% 65.95-70.71) Control participants showed no change, maintaining rate 29.14% 26.82-31.47) 2020 while treated improved 30.68% 27.88-33.48). During pandemic, steepening curves awareness treatment. However, slope being increased, change Older populations individuals lower level exhibited less improvement than younger educated individuals. People income experienced deceleration Conclusions Over recent decade, has been steeper observed. heterogeneous across different population groups, underscoring need targeted interventions address disparities improve populations.

Language: Английский

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2023 Clinical Practice Guidelines for Diabetes

Journal of Korean Diabetes, Journal Year: 2023, Volume and Issue: 24(3), P. 120 - 126

Published: Sept. 30, 2023

The Committee on Clinical Practice Guidelines of the Korean Diabetes Association updated previous clinical practice guidelines for adults with diabetes and prediabetes published eighth edition in May 2023. We performed a comprehensive systematic review recent trials evidence suitable population that could be applicable to real-world practice. These were developed enable all healthcare providers including physicians, experts, certified educators nationwide best care individuals setting. recommendations screening, medical nutrition therapy, pharmacologic therapy type 2 diabetes, obesity, hypertension, lipid management revised updated. use real-time continuous glucose monitoring (CGM) devices was recommended 1 treated multiple insulin injections, additional CGM metrics added blood control target.

Language: Английский

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AI Machine Learning–Based Diabetes Prediction in Older Adults in South Korea: Cross-Sectional Analysis

JMIR Formative Research, Journal Year: 2025, Volume and Issue: 9, P. e57874 - e57874

Published: Jan. 21, 2025

Abstract Background Diabetes is prevalent in older adults, and machine learning algorithms could help predict diabetes this population. Objective This study determined risk factors among adults aged ≥60 years using selected an optimized prediction model. Methods cross-sectional was conducted on 3084 Seoul from January to November 2023. Data were collected a mobile app (Gosufit) that measured depression, stress, anxiety, basal metabolic rate, oxygen saturation, heart average daily step count. Health coordinators recorded data diabetes, hypertension, hyperlipidemia, chronic obstructive pulmonary disease, percent body fat, muscle. The presence of the target variable, with various health indicators as predictors. Machine algorithms, including random forest, gradient boosting model, light extreme k-nearest neighbors, employed for analysis. dataset split into 70% training 30% testing sets. Model performance evaluated accuracy, precision, recall, F1 score, area under curve (AUC). Shapley additive explanations (SHAPs) used model interpretability. Results Significant predictors included hypertension ( χ ² 1 =197.294; P <.001), hyperlipidemia =47.671; age (mean: group 72.66 vs nondiabetes 71.81 years), stress 42.68 41.47; t 3082 =−2.858; =.004), rate 75.05 beats/min 73.14 beats/min; =−7.948; <.001). (XGBM) demonstrated best performance, accuracy 84.88%, precision 77.92%, recall 66.91%, score 72.00, AUC 0.7957. SHAP analysis top-performing XGBM revealed key diabetes: age, saturation. Hypertension strongly increased risk, while advanced elevated levels also showed significant associations. Hyperlipidemia higher rates further heightened probability. These results highlight importance directional impact specific features predicting providing valuable insights stratification targeted interventions. Conclusions focused modifiable factors, crucial establishing system automated collection information lifelog digital devices at service facilities.

Language: Английский

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Screening for Prediabetes and Diabetes in Korean Nonpregnant Adults: A Position Statement of the Korean Diabetes Association, 2022

Diabetes & Metabolism Journal, Journal Year: 2022, Volume and Issue: 46(6), P. 819 - 826

Published: Nov. 24, 2022

Diabetes screening serves to identify individuals at high-risk for diabetes who have not yet developed symptoms and diagnose an early stage. Globally, the prevalence of is rapidly increasing. Furthermore, obesity and/or abdominal obesity, which are major risk factors type 2 mellitus (T2DM), progressively increasing, particularly among young adults. Many patients with T2DM asymptomatic can accompany various complications time diagnosis, as well chronic develop duration increases. Thus, proper diagnosis essential care. Based on reports changing epidemiology in Korea, growing evidence from new national cohort studies screening, Korean Association has updated its clinical practice recommendations regarding screening. now recommended adults aged ≥35 years regardless presence factors, all (aged ≥19) any factors. Abdominal based waist circumference (men ≥90 cm, women ≥85 cm) was added list

Language: Английский

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Economic Evaluations of Screening Programs for Chronic Kidney Disease: A Systematic Review

Value in Health, Journal Year: 2023, Volume and Issue: 27(1), P. 117 - 128

Published: Aug. 31, 2023

Objectives The aim of this review is to appraise and assimilate evidence from studies that have reported on the cost-effectiveness screening programs for chronic kidney disease (CKD). Methods study protocol was registered PROSPERO. final search conducted 18 January 2023 using seven databases. Screening articles, data extraction, quality assessment performed by two independent reviewers. ISPOR-AMCP-NPC checklist used assess credibility included studies. Results From 4,948 retrieved studies, a total 20 were in qualitative synthesis. Studies found diabetic populations cost-effective (n=8, 57%) or even cost-saving (n=6, 43%). Four (67%) hypertensive also cost-effective. For general population, findings inconsistent across where many be (n=11, 69%), some (n=2, 12%), while others not (n=3, 19%). most influential parameters identified prevalence CKD cost screening. Conclusions patients with diabetes hypertension recommended point view. despite findings, majority demonstrated population cost-effective, depending mainly costs Healthcare decision makers need consider prevalence, stratification strategies, advocate lower reduce burden healthcare budgets make more favourable health-economic perspective.

Language: Английский

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Synergistic effect of non-alcoholic fatty liver disease and history of gestational diabetes to increase risk of type 2 diabetes

European Journal of Epidemiology, Journal Year: 2023, Volume and Issue: 38(8), P. 901 - 911

Published: May 31, 2023

Language: Английский

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A Population Pharmacokinetic Study to Compare a Novel Empagliflozin L-Proline Formulation with Its Conventional Formulation in Healthy Subjects

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(4), P. 522 - 522

Published: April 18, 2024

Empagliflozin is a sodium–glucose cotransporter 2 (SGLT2) inhibitor that commonly used for the treatment of type diabetes mellitus (T2DM). CKD-370 was newly developed as cocrystal formulation empagliflozin with co-former L-proline, which has been confirmed to be bioequivalent in South Korea. This study aimed quantify differences absorption phase and pharmacokinetic (PK) parameters two formulations healthy subjects by using population PK analysis. The plasma concentration data were obtained from randomized, open-label, crossover, 1 clinical studies Korean after single-dose administration. A model constructed nonlinear mixed-effects (NLME) approach (Monolix Suite 2021R1). Interindividual variability (IIV) interoccasion (IOV) investigated. final evaluated goodness-of-fit (GOF) diagnostic plots, visual predictive checks (VPCs), prediction errors, bootstrapping. adequately described two-compartment combined transit compartment first-order elimination. Log-transformed body weight significantly influenced systemic clearance (CL) volume distribution peripheral (V2) empagliflozin. GOF VPCs, bootstrapping suggested proposed adequate robust, good precision at different dose strengths. form did not affect drug, affected treatments.

Language: Английский

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Transcriptional Regulation of Multi-Tissue mRNA Expression by L-arabinose Mitigates Metabolic Disorders in Leptin Receptor-Deficient Mice

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104881 - 104881

Published: Aug. 9, 2024

Language: Английский

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Socioeconomic inequalities in the prevalence, non-awareness, non-treatment, and non-control of diabetes among South Korean adults in 2021

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(11), P. e0313988 - e0313988

Published: Nov. 21, 2024

The purpose of this study was to investigate socioeconomic inequalities in diabetes prevalence, non-awareness, non-treatment, and non-control among South Korean adults 2021. This cross-sectional used data from the 2021 National Health Nutrition Examination Survey. Relative concentration indices (RCIs) relative curves stratified by sex age were diabetes. lack treatment, rates aged 30 years older 15.9%, 29.5%, 33.3%, 76.1%, respectively. Diabetes more prevalent participants under 65 than those for both men (RCI: -0.081, RCI: -0.158, respectively) women -0.203, -0.292, respectively). larger absolute value RCI non-awareness non-treatment women, greater level 0.182, 0.154). Socioeconomic existed prevalence years. In men. Thus, preventive care monitoring are required, particularly individuals

Language: Английский

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