Drug Discovery Today,
Journal Year:
2024,
Volume and Issue:
29(8), P. 104062 - 104062
Published: June 12, 2024
Neurodegenerative
diseases
are
challenging
to
cure.
To
date,
no
cure
has
been
found
for
Alzheimer's
disease
or
Parkinson's
disease,
and
current
treatments
able
only
slow
the
progression
of
manage
their
symptoms.
After
an
introduction
complex
biology
these
diseases,
we
discuss
beneficial
effect
selenium-containing
agents,
which
show
neuroprotective
effects
in
vitro
vivo.
Indeed,
selenium
is
essential
trace
element
that
being
incorporated
into
innovative
organoselenium
compounds,
can
improve
outcomes
rodent
even
primate
models
with
neurological
deficits.
Herein,
critically
recent
findings
field
selenium-based
applications
disorders.
AIMS neuroscience,
Journal Year:
2020,
Volume and Issue:
8(1), P. 86 - 132
Published: Dec. 16, 2020
Alzheimer
disease
is
a
progressive
neurodegenerative
disorder,
mainly
affecting
older
people,
which
severely
impairs
patients'
quality
of
life.
In
the
recent
years,
number
affected
individuals
has
seen
rapid
increase.
It
estimated
that
up
to
107
million
subjects
will
be
by
2050
worldwide.
Research
in
this
area
revealed
lot
about
biological
and
environmental
underpinnings
Alzheimer,
especially
its
correlation
with
β-Amyloid
Tau
related
mechanics;
however,
precise
molecular
events
pathways
behind
are
yet
discovered.
review,
we
focus
our
attention
on
mechanics
may
lie
development.
particular,
briefly
describe
genetic
elements
discuss
specific
processes
potentially
associated
disease.
Biomolecules,
Journal Year:
2021,
Volume and Issue:
11(4), P. 543 - 543
Published: April 8, 2021
Background-Alzheimer's
disease
(AD)
is
a
multifactorial,
progressive,
neurodegenerative
that
characterized
by
memory
loss,
personality
changes,
and
decline
in
cognitive
function.
While
the
exact
cause
of
AD
still
unclear,
recent
studies
point
to
lifestyle,
diet,
environmental,
genetic
factors
as
contributors
progression.
The
pharmaceutical
approaches
developed
date
do
not
alter
More
than
two
hundred
promising
drug
candidates
have
failed
clinical
trials
past
decade,
suggesting
its
causes
may
be
highly
complex.
Medicinal
plants
herbal
remedies
are
now
gaining
more
interest
complementary
alternative
interventions
valuable
source
for
developing
AD.
Indeed,
several
scientific
described
use
various
medicinal
their
principal
phytochemicals
treatment
This
article
reviews
subset
herbs
anti-inflammatory,
antioxidant,
cognitive-enhancing
effects.
Methods-This
systematically
investigated
role
neuroprotective
bioactive
compounds
dementia
associated
with
Alzheimer's
pre-Alzheimer's
disease.
PubMed
Central,
Scopus,
Google
Scholar
databases
articles
were
collected,
abstracts
reviewed
relevance
subject
matter.
Conclusions-Medicinal
great
potential
part
an
overall
program
prevention
It
hoped
these
can
used
discovery
programs
identifying
safe
efficacious
small
molecules
European Journal of Medicinal Chemistry Reports,
Journal Year:
2024,
Volume and Issue:
11, P. 100154 - 100154
Published: April 7, 2024
Alzheimer's
disease
(AD),
the
main
dementia
type
accounting
for
over
70
%
of
entire
population,
progressive
decline
in
memory
and
executive
function.
AD
pathology
is
characterized
by
amyloid
fibrils
neurofibrillary
tangles.
Acetylcholinesterase
(AChE),
an
enzyme
involved
hydrolysis
neurotransmitter
acetylcholine,
consistently
colocalizes
with
deposits
characteristic
may
contribute
to
generation
proteins.
AChE
a
potent
amyloid-promoting
factor
when
compared
other
c-associated
inhibitors
play
vital
role
prevent
formation
toxic
oligomeric
form
peptide.
Recent
studies
have
reported
that
acetylcholinesterase
(ChE-Is)
are
present
plants,
fungi,
marine
products.
Some
cholinesterase
inhibitors,
obtained
from
plant
source
such
as
rivastigmine,
donepezil,
galantamine,
used
treatment
AD,
offer
alternative
approach
alleviate
its
symptoms
reducing
Aβ.
Due
limited
efficacy
current
drugs
there
huge
potential
phytomedicines
AD.
Medicinal
herbs
herbal
drug
preparations
traditionally
been
treat
neurological
disorders
exhibiting
anti-inflammatory
neuroprotective
properties.
Phytomedicines
containing
flavonoids,
polyphenols,
naturally
occurring
antioxidants
crosses
blood-brain
barrier
protect
neurons
oxidative
stress.
As
synthetic
drugs,
fewer
side
effects.
Therefore,
recent
research
focused
explore
develop
it
effective
In
our
review,
we
summarized
amyloid-deposition,
Acetylcholinesterase,
phytoconstituents
inhibitory
activity
treatment.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 10, 2025
Alzheimer's
disease
(AD)
is
a
distinctive
form
of
dementia
characterized
by
age-related
cognitive
decline
and
memory
impairment.
A
key
hallmark
AD
the
irreversible
overaccumulation
beta-amyloid
(Aβ)
in
brain,
associated
with
neuroinflammation
neuronal
death.
Although
Aβ
clearance
immunoregulation
have
been
major
therapeutic
strategies
for
AD,
highly
selective
transport
across
blood–brain
barrier
(BBB)
negatively
affects
delivery
efficacy
drugs
without
ability
to
cross
BBB.
In
this
review,
we
discuss
potential
lipid-based
nanoparticles
(LBNs)
as
promising
vehicles
drug
treatment.
LBNs,
composed
phospholipid
mono-
or
bilayer,
attracted
attention
due
their
exceptional
cellular
penetration
capabilities
loading
capabilities,
which
also
facilitate
cargo
transcytosis
Recent
advances
development
engineering
LBNs
overcome
existing
limitations
current
clinical
approaches
treatment
addressing
off-target
effects
low
efficacy.
Here,
review
pathways
BBB,
well
various
types
therapy,
including
exosomes,
liposomes,
solid
lipid
(SLNs),
nanostructured
carriers
(NLCs),
elucidate
properties,
preparation
methodologies,
efficacy,
thereby
offering
innovative
avenues
novel
translation
therapy.
Molecules,
Journal Year:
2021,
Volume and Issue:
27(1), P. 236 - 236
Published: Dec. 31, 2021
Curcumin,
the
dietary
polyphenol
isolated
from
Curcuma
longa
(turmeric),
is
commonly
used
as
an
herb
and
spice
worldwide.
Because
of
its
bio-pharmacological
effects
curcumin
also
called
“spice
life”,
in
fact
it
recognized
that
possesses
important
proprieties
such
anti-oxidant,
anti-inflammatory,
anti-microbial,
antiproliferative,
anti-tumoral,
anti-aging.
Neurodegenerative
diseases
Alzheimer’s
Diseases,
Parkinson’s
Multiple
Sclerosis
are
a
group
characterized
by
progressive
loss
brain
structure
function
due
to
neuronal
death;
at
present
there
no
effective
treatment
cure
these
diseases.
The
protective
effect
against
some
neurodegenerative
has
been
proven
vivo
vitro
studies.
current
review
highlights
latest
findings
on
neuroprotective
curcumin,
bioavailability,
mechanism
action
possible
application
for
prevention
or
disorders.
Materials,
Journal Year:
2021,
Volume and Issue:
14(12), P. 3332 - 3332
Published: June 16, 2021
AD
is
a
chronic
neurodegenerative
disease.
Many
different
signaling
pathways,
such
as
Wnt/β-catenin,
Notch,
ROS/JNK,
and
PI3K/Akt/mTOR
are
involved
in
Alzheimer's
disease
crosstalk
between
themselves.
A
promising
treatment
involves
the
uses
of
flavonoids,
one
most
curcumin;
however,
because
it
has
difficulty
permeating
blood-brain
barrier
(BBB),
must
be
encapsulated
by
drug
carrier.
Some
frequently
studied
lipid
nanocarriers,
liposomes,
micelles
PLGA.
These
carriers
further
conjugated
with
brain-targeting
agents
lactoferrin
transferrin.
In
this
review
paper,
curcumin
its
therapeutic
effects,
which
have
been
examined
vivo,
analyzed
then
delivery
systems
to
brain
addressed.
Overall,
analysis
literature
revealed
great
potential
for
treating
indicated
challenges
that
require
research.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(9), P. 4718 - 4718
Published: April 25, 2022
MicroRNAs
(miRNAs)
are
essential
post-transcriptional
gene
regulators
involved
in
various
neuronal
and
non-neuronal
cell
functions
play
a
key
role
pathological
conditions.
Numerous
studies
have
demonstrated
that
miRNAs
dysregulated
major
neurodegenerative
diseases,
such
as
Alzheimer’s
disease,
Parkinson’s
multiple
sclerosis,
amyotrophic
lateral
or
Huntington’s
disease.
Hence,
the
present
work,
we
constructed
comprehensive
overview
of
individual
microRNA
alterations
models
above
diseases.
We
also
provided
evidence
promising
biomarkers
for
prognostic
diagnostic
approaches.
In
addition,
summarized
data
from
literature
about
miRNA-based
therapeutic
applications
via
inhibiting
promoting
miRNA
expression.
finally
identified
overlapping
signature
across
including
miR-128,
miR-140-5p,
miR-206,
miR-326,
miR-155,
associated
with
etiological
cellular
mechanisms.
However,
it
remains
to
be
established
whether
what
extent
therapies
could
safely
exploited
future
effective
symptomatic
disease-modifying
approaches
different
human
disorders.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(8), P. 7318 - 7318
Published: April 15, 2023
Neurodegenerative
disorders
are
a
widespread
cause
of
morbidity
and
mortality
worldwide,
characterized
by
neuroinflammation,
oxidative
stress,
neuronal
depletion.
They
include
selective
malfunction
progressive
loss
neurons,
glial
cells,
neural
networks
in
the
brain
spinal
cord.
There
is
an
urgent
need
to
develop
new
more
effective
therapeutic
strategies
combat
these
devastating
diseases
because,
today,
there
no
treatment
that
can
cure
degenerative
diseases;
however,
we
have
many
symptomatic
treatments.
Current
nutritional
approaches
beginning
reflect
fundamental
change
our
understanding
health.
The
Mediterranean
diet
may
protective
effect
on
neurodegenerative
process
because
it
rich
antioxidants,
fiber,
omega-3
polyunsaturated
fatty
acids.
Increasing
knowledge
regarding
impact
regulation
at
genetic
molecular
levels
changing
way
consider
role
nutrition,
resulting
dietary
strategies.
Natural
products,
thanks
their
bioactive
compounds,
recently
undergone
extensive
exploration
study
for
potential
variety
diseases.
Targeting
simultaneous
multiple
mechanisms
action
neuroprotection
approach
with
could
prevent
cell
death
restore
function
damaged
neurons.
For
reasons,
this
review
will
be
focused
natural
products
associations
between
Mediterranean-style
(MD),
diseases,
markers
neurodegeneration.
