Cellular and Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 43(8), P. 3847 - 3884
Published: Sept. 19, 2023
Language: Английский
Molecules, Journal Year: 2022, Volume and Issue: 27(6), P. 1816 - 1816
Published: March 10, 2022
Acetylcholine, a neurotransmitter secreted by cholinergic neurons, is involved in signal transduction related to memory and learning ability. Alzheimer’s disease (AD), progressive commonly diagnosed neurodegenerative disease, characterized cognitive decline behavioral disorders. The pathogenesis of AD complex remains unclear, being affected various factors. hypothesis the earliest theory about AD. Cholinergic atrophy are accelerated age-related diseases such as In addition, abnormal central changes can also induce phosphorylation ttau protein, nerve cell inflammation, apoptosis, other pathological phenomena, but exact mechanism action still unclear. Due unclear pathogenesis, effective methods prevent treat unavailable, research explore novel therapeutic drugs active world. This review summaries role signaling correlation between pathway with risk factors provides latest efficient treatment
Language: Английский
Citations
377
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 24(1), P. 340 - 340
Published: Dec. 25, 2022
(‒)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea. Thanks to multiple interactions with cell surface receptors, intracellular signaling pathways, and nuclear transcription factors, EGCG possesses a wide variety of anti-inflammatory, antioxidant, antifibrotic, anti-remodelation, tissue-protective properties which may be useful treatment various diseases, particularly cancer, neurological, cardiovascular, respiratory, metabolic disorders. This article reviews current information on biological effects above-mentioned disorders relation molecular pathways controlling inflammation, oxidative stress, apoptosis.
Language: Английский
Citations
119
Antioxidants, Journal Year: 2022, Volume and Issue: 11(3), P. 525 - 525
Published: March 9, 2022
Neurodegenerative diseases, cardiovascular disease (CVD), hypertension, insulin resistance, cancer, and other degenerative processes commonly appear with aging.
Language: Английский
Citations
72
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 1659 - 1659
Published: Jan. 14, 2023
Alzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative typically characterized by memory loss, personality changes, and decline in overall cognitive function. Usually manifesting individuals over the age of 60, this most prevalent type dementia remains fifth leading cause death among Americans aged 65 older. While development effective treatment prevention for AD major healthcare goal, unfortunately, therapeutic approaches to date have yet find plan that produces long-term improvement. Drugs may be able slow down progression rate are being introduced market; however, there has been no previous solution preventing or reversing disease-associated decline. Recent studies identified several factors contribute severity disease: diet, lifestyle, stress, sleep, nutrient deficiencies, mental health, socialization, toxins. Thus, increasing evidence supports dietary other lifestyle changes as potentially ways prevent, slow, reverse progression. Studies also demonstrated personalized, multi-therapeutic approach needed improve metabolic abnormalities AD-associated These suggest effects abnormalities, such insulin resistance, chronic inflammation, hypovitaminosis D, hormonal hyperhomocysteinemia, process. Therefore program based on an individual's genetics biochemistry preferable single-drug/mono-therapeutic approach. This article reviews these strategies identify attenuate all risk specific each affected individual. systematically incorporated multiple target numerous simultaneously treat We included high-quality clinical trials observational focused programs comprising physical, activity, well nutritional aspects. Articles from PubMed Central, Scopus, Google Scholar databases were collected, abstracts reviewed relevance subject matter. Epidemiological, pathological, toxicological, genetic, biochemical concluded represents complex network insufficiency. The research explored manuscript confirm need multifactorial various AD. A single-drug delay loss but, date, not prevented reversed it. Diet, physical environment disease, and, therefore, multi-factorial optimization support function offers rational strategy. targets underlying more than mono-therapeutic
Language: Английский
Citations
57
Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 393 - 393
Published: March 25, 2024
The aging of the global population has increased prevalence neurodegenerative conditions. Bacopa monnieri (BM), an herb with active compounds, such as bacosides A and B, betulinic acid, loliolide, asiatic quercetin, demonstrates potential for brain health. Limited research been conducted on therapeutic applications BM in This systematic review aims to project BM’s beneficial role disorders. anti-apoptotic antioxidant actions can repair damaged neurons, stimulate kinase activity, restore synaptic function, improve nerve transmission, increase neuroprotection. included twenty-two clinical trials demonstrated that reduce Nuclear Factor-κB phosphorylation, emotional cognitive functions, anhedonia, hyperactivity, sleep routine, depression, attention deficit, learning problems, memory retention, impulsivity, psychiatric problems. Moreover, levels pro-inflammatory biomarkers oxidative stress. Here, we highlight provides notable benefits serve a complementary approach care patients conditions associated adds growing interest natural products their by improving our understanding mechanisms underlying function neurodegeneration informing development new strategies diseases.
Language: Английский
Citations
37
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116373 - 116373
Published: March 4, 2024
Alzheimer's disease (AD), characterized by cognitive dysfunction and other behavioral abnormalities, is a progressive neurodegenerative that occurs due to aging. Currently, effective drugs mitigate or treat AD remain unavailable. associated with several abnormalities in neuronal energy metabolism, such as decreased glucose uptake, mitochondrial dysfunction, defects cholesterol metabolism. Amp-activated protein kinase (AMPK) an important serine/threonine regulates the status of cells. AMPK widely present eukaryotic cells can sense regulate metabolism maintain supply demand balance, making it promising target for metabolism-based therapy. Therefore, this review aimed discuss molecular mechanism pathogenesis provide theoretical basis development new anti-AD drugs. To mechanisms phytochemicals treatment via pathway regulation, we searched PubMed, Google Scholar, Web Science, Embase databases using specific keywords related September 2023. Phytochemicals activate exert therapeutic effects AD. The these include inhibiting Aβ aggregation, preventing Tau hyperphosphorylation, inflammatory response glial activation, promoting autophagy, suppressing anti-oxidative stress. Additionally, AMPK-related pathways are involved mechanism, including AMPK/CaMKKβ/mTOR, AMPK/SIRT1/PGC-1α, AMPK/NF-κB/NLRP3, AMPK/mTOR, PERK/eIF2α pathways. Notably, urolithin A, artemisinin, justicidin berberine, stigmasterol, arctigenin, rutaecarpine agonists effects. Several may have potential applications treatment. Overall, phytochemical-based overcome barriers diseases.
Language: Английский
Citations
15
Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102680 - 102680
Published: Feb. 1, 2025
Language: Английский
Citations
2
Biomolecules, Journal Year: 2021, Volume and Issue: 11(5), P. 767 - 767
Published: May 20, 2021
The potential to treat neurodegenerative diseases (NDs) of the major bioactive compound green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now suggest that EGCG targets protein misfolding and aggregation, a common cause pathological mechanism in many NDs. Several studies have shown interacts with misfolded proteins such as amyloid beta-peptide (Aβ), linked Alzheimer’s disease (AD), α-synuclein, Parkinson’s (PD). To date, NDs constitute serious public health problem, causing financial burden for care systems worldwide. Although current treatments provide symptomatic relief, they do not stop or even slow progression these devastating disorders. Therefore, there an urgent need develop effective drugs incurable ailments. It expected targeting can serve therapeutic strategy since neurodegeneration. In this context, may offer great opportunities drug discovery review critically discusses role provides updated information on scientific evidence potentially be used fatal brain
Language: Английский
Citations
73
Saudi Pharmaceutical Journal, Journal Year: 2021, Volume and Issue: 29(8), P. 879 - 907
Published: July 15, 2021
Memory, one of the most vital aspects human brain, is necessary for effective survival an individual. 'Memory' can be defined in various ways but overall view, memory retention information that brain grasps. Different factors are responsible disbalance brain's hippocampus region and acetylcholine level, which masters cognitive functions. Plants a source pharmacologically potent drug molecules high efficacy. Recently herbal medicine has evolved rapidly, gaining great acceptance worldwide due to their natural origin fewer side effects. In this review, authors have discussed mechanisms pharmacological action bioactive compounds boost memory. Moreover, review presents update different herbs products could act as enhancers how they potentially utilized near future treatment severe disorders. addition, also discuss differences biological activity same herb emphasize requirement higher standardization cultivation methods plant processing. The demand further studies evaluating interactions drugs mentioned.
Language: Английский
Citations
68
Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 22
Published: April 11, 2022
Alzheimer’s disease (AD) is a common neurodegenerative brain disorder that causes cellular response alterations, such as impaired cholinergic mechanism, amyloid-beta (Aβ) AD aggregation, neuroinflammation, and several other pathways. still the most prevalent form of dementia affects many individuals across globe. The exact cause obscure. There are yet no effective medications for halting, preventing, or curing AD’s progress. Plenty natural products isolated from sources analyzed in preclinical clinical settings neuroprotective effects preventing treating AD. In addition, their derivatives have been promising Natural bioactive compounds play an active modulatory role pathological molecular mechanisms development. This review focuses on plant demonstrated activities maybe to treat prevent this article summarizes literature pertaining agents treatment Rapid metabolism, nonspecific targeting, low solubility, lack BBB permeability, limited bioavailability shortcomings molecules We can use nanotechnology nanocarriers based different types approaches.
Language: Английский
Citations
59