Addressing the inter‐individual variation in response to consumption of plant food bioactives: Towards a better understanding of their role in healthy aging and cardiometabolic risk reduction

Molecular Nutrition & Food Research, Journal Year: 2016, Volume and Issue: 61(6)

Published: Sept. 30, 2016

Bioactive compounds in plant‐based foods have health properties that contribute to the prevention of age‐related chronic diseases, particularly cardiometabolic disorders. Conclusive proof and understanding these benefits humans is essential order provide effective dietary recommendations but, so far, evidence obtained from human intervention trials limited contradictory. This partly due differences between individuals absorption, distribution, metabolism excretion bioactive compounds, as well heterogeneity their biological response regarding outcomes. Identifying main factors underlying inter‐individual differences, developing new innovative methodologies account for such variability constitute an overarching goal ultimately optimize beneficial effects plant food bioactives each every one us. In this respect, position paper COST Action FA1403‐POSITIVe examines likely affect individual responses consumption presents perspectives assessment consideration variability.

Language: Английский

---

Nutrition for the ageing brain: Towards evidence for an optimal diet

Ageing Research Reviews, Journal Year: 2016, Volume and Issue: 35, P. 222 - 240

Published: Oct. 7, 2016

As people age they become increasingly susceptible to chronic and extremely debilitating brain diseases. The precise cause of the neuronal degeneration underlying these disorders, indeed normal ageing remains however elusive. Considering limits existing preventive methods, there is a desire develop effective safe strategies. Growing preclinical clinical research in healthy individuals or at early stage cognitive decline has demonstrated beneficial impact nutrition on functions. present review most recent series produced by Nutrition Mental Performance Task Force under auspice International Life Sciences Institute Europe (ILSI Europe). latest scientific advances specific how dietary nutrients non-nutrient may affect are presented. Furthermore, several key points related mechanisms contributing ageing, pathological conditions affecting function, biomarkers also discussed. Overall, findings inconsistent fragmented more warranted determine establish dose-response relationships for optimal maintenance different population subgroups. Such approaches likely provide necessary evidence portfolios that will inform about new recommendations prevent decline.

Language: Английский

---

Phenyl-γ-valerolactones and phenylvaleric acids, the main colonic metabolites of flavan-3-ols: synthesis, analysis, bioavailability, and bioactivity

Natural Product Reports, Journal Year: 2018, Volume and Issue: 36(5), P. 714 - 752

Published: Nov. 23, 2018

This review focuses on several key aspects related to the main group of phenolic metabolites in circulation.

Language: Английский

---

Identifying biomarkers of dietary patterns by using metabolomics

American Journal of Clinical Nutrition, Journal Year: 2016, Volume and Issue: 105(2), P. 450 - 465

Published: Dec. 29, 2016

Language: Английский

---

Validation of biomarkers of food intake—critical assessment of candidate biomarkers

Genes & Nutrition, Journal Year: 2018, Volume and Issue: 13(1)

Published: May 30, 2018

Biomarkers of food intake (BFIs) are a promising tool for limiting misclassification in nutrition research where more subjective dietary assessment instruments used. They may also be used to assess compliance guidelines or intervention. therefore hold promise direct and objective measurement intake. However, the number comprehensively validated biomarkers is limited just few. Many new candidate emerge from metabolic profiling studies advances chemistry. Furthermore, identified based on extensive literature reviews such as described Biomarker Food Intake Reviews (BFIRev). To systematically critically validity intake, it necessary outline streamline an optimal reproducible validation process. A consensus-based procedure was provide evaluate set most important criteria systematic BFIs. As result, developed including eight criteria, plausibility, dose-response, time-response, robustness, reliability, stability, analytical performance, inter-laboratory reproducibility. The has dual purpose: (1) estimate current level approach (2) pinpoint which additional needed full each biomarker This position paper outlines second step BFIRev but identified, e.g., metabolomic studies.

Language: Английский

---