Long COVID prevalence and impact on quality of life 2 years after acute COVID-19

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: July 11, 2023

There has been an increasing interest in the long-term impact of long COVID. However, only a few studies have investigated clinical manifestations COVID after 24 months acute infection. In this study, prospective online surveys were conducted adults previously diagnosed with coronavirus disease 2019 (COVID-19) South Korea between February 13 and March 13, 2020, at 6, 12, COVID-19. We self-reported symptoms EuroQol-5-dimension index. Among 900 individuals enrolled initially, 150 completed all 3 surveys. After excluding cases COVID-19 reinfection, 132 included final analysis. participants, 94 (71.2%) experienced The most frequently reported fatigue (34.8%), amnesia (30.3%), concentration difficulties (24.2%), insomnia (20.5%), depression (19.7%). Notably, no significant differences noted incidence terms number vaccinations received. Although neuropsychiatric quality life improved over time, it continued to affect 32.7% participants. Symptoms COVID, particularly symptoms, tend persist vaccination or received may not significantly

Language: Английский

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Long COVID and rehabilitation

Journal of the Formosan Medical Association, Journal Year: 2023, Volume and Issue: 123, P. S61 - S69

Published: April 13, 2023

Coronavirus disease 2019 (COVID-19) has caused tremendous morbidity and mortality worldwide. The large number of post-COVID survivors drawn attention to the management condition, known as long COVID. This review examines current knowledge COVID, regarding its epidemiology, mechanism, clinical presentations in both adults children. We also rehabilitation principles, modules, effects, share Taiwan's efforts provide a top-down, nationwide care framework for COVID patients. Dyspnea, chronic cough, fatigue are most commonly reported symptoms first 6 months after infection, but cognitive impairment psychological may persist beyond this time. Several possible mechanisms behind these were proposed, remained unconfirmed. These negatively impact individuals' function, activities, participation quality life. Rehabilitation is key element achieve functional improvement. Early should start with comprehensive evaluation identification red flags. Exercise-based therapy, an essential part can be conducted different including telerehabilitation. Post-exertional symptom exacerbation orthostatic hypotension carefully monitored during exercise. Randomized control trials sample size needed determine optimal timing, dosage, modules.

Language: Английский

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Understanding How Post–COVID-19 Condition Affects Adults and Health Care Systems

JAMA Health Forum, Journal Year: 2023, Volume and Issue: 4(7), P. e231933 - e231933

Published: July 7, 2023

Importance Post–COVID-19 condition (PCC), also known as long COVID, encompasses the range of symptoms and sequelae that affect many people with prior SARS-CoV-2 infection. Understanding functional, health, economic effects PCC is important in determining how health care systems may optimally deliver to individuals PCC. Observations A rapid review literature showed hospitalization for severe critical illness limit a person’s ability perform day-to-day activities employment, increase their risk incident conditions use primary short-term services, have negative association household financial stability. Care pathways integrate care, rehabilitation specialized assessment clinics are being developed support needs However, comparative studies determine optimal models based on effectiveness costs remain limited. The likely large-scale associations economies will require substantial investment research, clinical policy mitigate these effects. Conclusions Relevance An accurate understanding additional at individual system levels informing resource planning, including identification affected by

Language: Английский

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Characteristics of long COVID and the impact of COVID-19 vaccination on long COVID 2 years following COVID-19 infection: prospective cohort study

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 9, 2024

Abstract This prospective cohort study aimed to identify characteristics of long COVID and any potential mitigating effects COVID-19 vaccinations in patients 24 months following infection. Adult diagnosed with between February 17, 2020, March 24, were scheduled visit the hospital four times (6, 12, 18, after infection) assess their symptoms, quality life, mental health. Among 235 patients, 121 (51.5%) completed visits. Of these, 59.5% female, a median age 52 years. Mild moderate disease severity identified 101 (83.4%) patients. A total 75 participants (62.0%) still experiencing symptoms acute Fatigue, amnesia, difficulty concentrating, insomnia most common symptoms. The frequency neuropsychiatric did not differ based on vaccination status or number doses received. Quality life improved over time for participants, but 32.2% respondents reported anxiety/depression at end study. Overall, our demonstrates that can persist up infection, affecting health life.

Language: Английский

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Updated Clinical Practice Guidelines for the Diagnosis and Management of Long COVID

Infection and Chemotherapy, Journal Year: 2024, Volume and Issue: 56(1), P. 122 - 122

Published: Jan. 1, 2024

"Long COVID" is a term used to describe condition when the symptoms and signs associated with coronavirus disease 2019 (COVID-19) persist for more than three months among patients infected COVID-19; this has been reported globally poses serious public health issue. Long COVID can manifest in various forms, highlighting need appropriate evaluation management by experts from fields. However, due lack of clear clinical definitions, knowledge pathophysiology, diagnostic methods, treatment protocols, it necessary develop best standard guidelines based on scientific evidence date. We developed guideline diagnosing treating long analyzing latest research data collected start COVID-19 pandemic until June 2023, along consensus expert opinions. This provides recommendations diagnosis that be applied practice, total 32 key questions related COVID. The should comprehensive, including medical history, physical examination, blood tests, imaging studies, functional tests. To reduce risk developing COVID, vaccination antiviral during acute phase are recommended. will revised there reasonable updates availability new

Language: Английский

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Identification and diagnosis of long COVID-19: A scoping review

Progress in Biophysics and Molecular Biology, Journal Year: 2023, Volume and Issue: 182, P. 1 - 7

Published: May 12, 2023

Language: Английский

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Interplay between Comorbidities and Long COVID: Challenges and Multidisciplinary Approaches

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 835 - 835

Published: July 11, 2024

Long COVID, a name often given to the persistent symptoms following acute SARS-CoV-2 infection, poses multifaceted challenge for health. This review explores intrinsic relationship between comorbidities and autoimmune responses in shaping trajectory of long COVID. Autoantibodies have emerged as significant players COVID-19 pathophysiology, with implications disease severity progression. Studies show immune dysregulation persisting months after marked by activated innate cells high cytokine levels. The presence autoantibodies against various autoantigens suggests their potential comorbid factors Additionally, formation complexes may lead severe progression, highlighting urgency early detection intervention. Furthermore, COVID is highly linked cardiovascular complications neurological symptoms, posing challenges diagnosis management. Multidisciplinary approaches, including vaccination, tailored rehabilitation, pharmacological interventions, are used mitigating COVID’s burden. However, numerous persist, from evolving diagnostic criteria addressing psychosocial impact predicting outcomes. Leveraging AI-based applications holds promise enhancing patient management improving our understanding As research continues unfold, unravelling complexities remains paramount effective intervention care.

Language: Английский

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COVID-19 Vaccination in Korea: Past, Present, and the Way Forward

Journal of Korean Medical Science, Journal Year: 2022, Volume and Issue: 37(47)

Published: Jan. 1, 2022

Since its first emergence in late 2019, severe acute respiratory syndrome coronavirus-2 has claimed more than 6.5 million lives worldwide and continues to infect hundreds of thousands people daily. To combat this once-in-a-century disaster, several vaccines have been developed at unprecedented speeds. Novel vaccine platforms (messenger ribonucleic acid adenoviral vector vaccines) played a major role the current pandemic. In Korea, six vaccines, including domestically recombinant vaccine, approved. As other countries, proven be safe highly effective Korea. However, rare serious adverse events breakthrough infections undermined public trust even while benefits vaccination far outweigh risks. The rise omicron variant subsequent increase excess mortality demonstrated that are key component pandemic response, it alone can fail without non-pharmaceutical interventions like masking social distancing. coronavirus disease revealed both strengths weaknesses our healthcare system preparedness. When next arrives, improved risk communication development should prioritized. enable timely development, is essential make strategic sufficient investments research development.

Language: Английский

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Clinical Characteristics of Post-COVID-19 Persistent Cough in the Omicron Era

Allergy Asthma and Immunology Research, Journal Year: 2023, Volume and Issue: 15(3), P. 395 - 395

Published: Jan. 1, 2023

Cough is one of the most common symptoms acute coronavirus disease 2019, but cough may persist for weeks or months. This study aimed to examine clinical characteristics patients with post-coronavirus (COVID) persistent in Omicron era. We conducted a pooled analysis comparing 3 different groups: 1) prospective cohort post-COVID (> weeks; n = 55), 2) retrospective 66), and 3) non-COVID chronic (CC) 8 100). health status was assessed using patient-reported outcomes (PROs). Outcomes, including PROs systemic symptoms, were longitudinally evaluated registry participants receiving usual care. A total 121 100 CC studied. Baseline cough-specific PRO scores did not significantly differ between groups. There no significant differences chest imaging abnormality lung function However, proportions fractional exhaled nitric oxide (FeNO) ≥ 25 ppb 44.7% those 22.7% CC, which different. In longitudinal assessment (n 43), PROs, such as severity Leicester Questionnaire (LCQ) scores, improved visits 1 2 (visit interval: median 35 [interquartile range, IQR: 23-58] days). LCQ score, 83.3% showed improvement (change +1.3), 7.1% had worsened (≤ -1.3). The number 4 (IQR: 2-7) at visit decreased 0-4) 2. summary, similar overall CC. Current guideline-based approaches be effective cough. Measurement FeNO levels also useful management.

Language: Английский

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Visual analysis of hotspots and trends in long COVID research based on bibliometric

Heliyon, Journal Year: 2024, Volume and Issue: 10(2), P. e24053 - e24053

Published: Jan. 1, 2024

After severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, a series of symptoms may persist for long time, which is now called COVID. It was found that COVID can affect all patients with COVID-19. Therefore, has become hot topic. In this study, we used the WOS database as sample data source to conduct bibliometric and visual analysis 1765 articles over past three years through VOSviewer R package. The results show countries/authors in Europe United States America contribute most articles, their cooperation also active. Keyword co-occurrence identified four clusters, important topics including mechanism, clinical symptoms, epidemiological characteristics, management/treatment Themes such "cognitive impairment", "endothelial dysfunction", "diagnosis", "biomarkers" are likely be focus new attention coming period. addition, put forward possible research opportunities on researchers practitioners facilitate future research.

Language: Английский

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