Mucosal immunoglobulins of teleost fish: A decade of advances

Developmental & Comparative Immunology, Journal Year: 2021, Volume and Issue: 121, P. 104079 - 104079

Published: March 27, 2021

Immunoglobulins (Igs) are complex glycoproteins that play critical functions in innate and adaptive immunity of all jawed vertebrates. Given the unique characteristics mucosal barriers, secretory Igs (sIgs) have specialized to maintain homeostasis keep pathogens at bay tissues from fish mammals. In teleost fish, three main IgH isotypes, IgM, IgD IgT/Z can be found different proportions secretions skin, gills, gut, nasal, buccal, pharyngeal mucosae. Similar role mammalian IgA, IgT plays a predominant immunity. Recent studies illuminated primordial sIgs both microbiota pathogen control sites. Ten years ago, was discovered an immunoglobulin class Aiming this 10-year anniversary, goal review is summarize current status field since discovery, while identifying knowledge gaps future avenues will move forward basic applied science areas.

Language: Английский

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Commensal bacteria‐immunity crosstalk shapes mucosal homeostasis in teleost fish

Reviews in Aquaculture, Journal Year: 2021, Volume and Issue: 13(4), P. 2322 - 2343

Published: May 28, 2021

Abstract Fish harbour complex and dynamic microbiota in their mucosal surfaces. Due to the vital role of commensal many biological functions including growth enhancement, nutrition, development, metabolism immune response, scholars have begun refer microbiome as an ‘extended self’. Several studies indicated that a normal contributes fish health, disturbances microbial communities may lead secondary infections disease. Under evolutionary selective forces, developed excellent innate mechanisms adaptive system composed B cells T discriminate between beneficial opportunistic bacteria for homeostasis. Many functional demonstrated involvement cells, cytokines Igs maintaining homeostasis, microbes contribute improving barrier against external threats. Additionally, host‐derived probiotics been empirically used aquaculture sector provide effective protection diseases. Although little is known about interactions compared mammals, managing represent promising alternative antibiotics disease prevention control. This review thus provides updated comprehensive summary currently characterized microbe compositions tissues. Thereafter, current knowledge on crosstalk application also discussed herein, thereby providing theoretical basis development microbe‐based control technologies aquaculture.

Language: Английский

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Immunity of the intestinal mucosa in teleost fish

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 133, P. 108572 - 108572

Published: Jan. 28, 2023

Language: Английский

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Teleost swim bladder, an ancient air-filled organ that elicits mucosal immune responses

Cell Discovery, Journal Year: 2022, Volume and Issue: 8(1)

Published: April 5, 2022

The air-filled organs (AOs) of vertebrates (lungs and swim bladders) have evolved unique functions (air-breathing or buoyancy control in water) to adapt different environments. Thus far, immune responses microbes AOs been described exclusively the lungs tetrapods. Similar lungs, bladders (SBs) represent a mucosal surface, feature that leads us hypothesize role for SB immunity. In this study, we demonstrate secretory IgT (sIgT) is key immunoglobulin (Ig) responding viral challenge, only Ig involved neutralization organ. support these findings, found load from fish devoid sIgT was much higher than fish. Interestingly, similar mammals, represents surface with lowest content microbiota. Moreover, main class coating their suggesting homeostasis addition well-established control, our findings reveal previously unrecognized function teleost adaptive upon pathogenic as well unidentified antiviral defense. Overall, indicate despite phylogenetic distance physiological roles mammalian they both analogous against which likely originated independently through process convergent evolution.

Language: Английский

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Regulatory roles of cytokines in T and B lymphocytes-mediated immunity in teleost fish

Developmental & Comparative Immunology, Journal Year: 2023, Volume and Issue: 144, P. 104621 - 104621

Published: Feb. 20, 2023

Language: Английский

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Effects of Citrobacter freundii on sturgeon: Insights from skin mucosal immunology and microbiota

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 149, P. 109527 - 109527

Published: March 30, 2024

Language: Английский

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Fructose Promotes Crucian Carp Survival Against Aeromonas hydrophila Infection

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: March 21, 2022

Aquatic food is becoming an important source that provides micronutrients to human beings. The decline of wild aquatic animals makes aquaculture become increasingly play this role. However, infectious diseases, especially bacterial infection, represent severe threat aquaculture, which causes huge economic loss. Meanwhile, strategies in managing infection antibiotic-independent way are still lacking. In study, we monitor the metabolomic shift crucian carp upon Aeromonas hydrophila infection. We find metabolism fish died distinct from ones survived. By multivariate analysis, identify fructose as a crucial biomarker whose abundance significantly different dying and surviving groups where group has higher content than group. Exogenous supplementation increases survival rate by 27.2%. Quantitative gene expression analysis demonstrated enhances lysozyme complement 3 expression, also confirmed serum level. Furthermore, augmented C3 levels enhance cell lytic activity contribute reduced load vivo. Thus, our study demonstrates metabolism-based approach manage through modulating immune response clear

Language: Английский

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Response of immunoglobulin M in gut mucosal immunity of common carp (Cyprinus carpio) infected with Aeromonas hydrophila

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 17, 2022

Immunoglobulin (Ig) M is an important immune effector that protects organisms from a wide variety of pathogens. However, little known about the response gut mucosal IgM during bacterial invasion. Here, we generated polyclonal antibodies against common carp and developed model infection with Aeromonas hydrophila via intraperitoneal injection. Our findings indicated both innate adaptive responses were effectively elicited after A. infection. Upon infection, + B cells strongly induced in head kidney, bacteria-specific detected high levels mucus serum. Moreover, our results suggested may vary different strategies. Overall, revealed infected exhibited resistance to this representative enteropathogenic bacterium upon reinfection, suggesting plays key role defense mechanisms Significantly, second injection induces strong local immunity gut, which essential for protection intestinal pathogens, providing reasonable insights vaccine preparation.

Language: Английский

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Aggregation and proliferation of B cells and T cells in MALTs upon Cryptocaryon irritans infection in large yellow croaker Larimichthys crocea

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 149, P. 109535 - 109535

Published: April 5, 2024

Language: Английский

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The mucosal immunity in crustaceans: Inferences from other species

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 152, P. 109785 - 109785

Published: July 23, 2024

Language: Английский

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