Diabetes Research and Clinical Practice, Journal Year: 2025, Volume and Issue: unknown, P. 112129 - 112129
Published: March 1, 2025
Language: Английский
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Oct. 31, 2023
The human plasma lipidome captures risk for cardiometabolic diseases. To discover new lipid-associated variants and understand the link between lipid species disorders, we perform univariate multivariate genome-wide analyses of 179 in 7174 Finnish individuals. We fine-map associated loci, prioritize genes, examine their disease links 377,277 FinnGen participants. identify 495 genome-trait associations 56 genetic loci including 8 novel with a considerable boost provided by analysis. For 26 fine-mapping identifies high causal probability, 14 coding indicating likely genes. A phenome-wide analysis across 953 endpoints reveals 40 loci. 11 coronary artery variants, detect strong species. Our study demonstrates power correlated lipidomics data diseases beyond standard lipids.
Language: Английский
Citations
124
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2249 - 2249
Published: Feb. 13, 2024
Lipids represent a large group of biomolecules that are responsible for various functions in organisms. Diseases such as diabetes, chronic inflammation, neurological disorders, or neurodegenerative and cardiovascular diseases can be caused by lipid imbalance. Due to the different stereochemical properties composition fatty acyl groups molecules most classes, quantification lipids development lipidomic analytical techniques problematic. Identification species from complex matrices is difficult, therefore individual steps, which include extraction, separation, detection lipids, must chosen properly. This review critically documents recent strategies analysis sample pretreatment instrumental data interpretation published last five years (2019 2023). The advantages disadvantages extraction methods covered. step comprises identification quantification. Mass spectrometry (MS) used technique analysis, performed direct infusion MS approach combination with suitable separation liquid chromatography gas chromatography. Special attention also given correct evaluation obtained analyses. Only accurate, precise, robust reliable able bring useful information, may contribute clarification some at molecular level, putative biomarkers and/or therapeutic targets.
Language: Английский
Citations
18
Saudi Pharmaceutical Journal, Journal Year: 2023, Volume and Issue: 31(12), P. 101870 - 101870
Published: Nov. 10, 2023
This review aims to provide a thorough examination of the benefits, challenges, and advancements in utilizing lipids for more effective drug delivery, ultimately contributing development innovative approaches pharmaceutical science. Lipophilic drugs, characterized by low aqueous solubility, present formidable challenge achieving delivery absorption within human body. To address this issue, one promising approach involves harnessing potential lipids. Lipids, their diverse forms, serve as carriers, leveraging unique capacity enhance stability, these challenging drugs. By facilitating improved intestinal solubility selective lymphatic porously permeable offer an array possibilities delivery. versatile characteristic not only bolsters pharmacological efficacy drugs with bioavailability but also contributes enhanced therapeutic performance, reducing required dose size associated costs. comprehensive delves into strategic formulation that employ carriers ameliorate bioavailability. Emphasis is placed on critical considerations lipid type, composition, processing techniques when designing lipid-based formulations. meticulously examines multifaceted challenges come hand formulations lipophilic offering insightful perspective future trends. Regulatory broad spectrum applications are thoughtfully discussed. In summary, presents valuable repository insights utilization all aimed at elevating
Language: Английский
Citations
36
Chemical Communications, Journal Year: 2024, Volume and Issue: 60(16), P. 2137 - 2151
Published: Jan. 1, 2024
In this feature article, we discuss quantitative mass spectrometry imaging of therapeutics and biomolecules conducted by recent studies for matrix-assisted laser desorption/ionization (MALDI) desorption electrospray ionization (DESI) techniques.
Language: Английский
Citations
15
Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)
Published: Feb. 21, 2025
Lipid metabolism is a well-regulated process essential for maintaining cellular functions and energy homeostasis. Dysregulation of lipid associated with various conditions, including cardiovascular diseases, neurodegenerative disorders, metabolic syndromes. This review explores the mechanisms underlying metabolism, emphasizing roles key species such as triglycerides, phospholipids, sphingolipids, sterols in physiology pathophysiology. It also examines genetic environmental factors contributing to dysregulation challenges diagnosing managing lipid-related disorders. Recent advancements lipid-lowering therapies, PCSK9 inhibitors, ezetimibe, bempedoic acid, olpasiran, provide promising treatment options. However, these are accompanied by related cost, accessibility, patient adherence. The highlights need personalized medicine approaches address interplay between genetics metabolism. As lipidomics advanced diagnostic tools continue progress, deeper understanding disorders could pave way more effective therapeutic strategies.
Language: Английский
Citations
1
MedComm, Journal Year: 2024, Volume and Issue: 5(6)
Published: May 24, 2024
Abstract White adipose tissue is not only a highly heterogeneous organ containing various cells, such as adipocytes, stem and progenitor immune but also an endocrine that important for regulating metabolic homeostasis. In individuals with obesity, dynamic cellular changes in result phenotypic switching dysfunction, including pathological expansion, WAT fibrosis, cell infiltration, endoplasmic reticulum stress, ectopic lipid accumulation, ultimately leading to chronic low‐grade inflammation insulin resistance. Recently, many distinct subpopulations of have been identified, providing new insights into the potential mechanisms dysfunction obesity. Therefore, targeting white therapeutic agent treating obesity obesity‐related diseases great scientific interest. Here, we provide overview remodeling discuss underlying regulatory dysfunction. Currently, studies uncovered promising targets strategies treatment. We outline signaling pathways summarize existing antiobesity treatment pharmacological approaches, lifestyle interventions, novel therapies.
Language: Английский
Citations
8
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 16, 2024
Abstract Cell membranes undergo biophysical remodelling as an adaptation to the surroundings and perform specific biological functions. However, extent relevance of such changes in human immune systems remain unknown, largely due lack high throughput multidimensional methodologies. Here, we describe a cytometry-based method with single-cell resolution which fills this technological gap by combining profiling conventional biomarker analysis. This platform allows reveal notable cell type-dependent membrane fluidity during stimulations diseases. Using cells exposed tumour microenvironment well from long COVID chronic lymphocyte leukaemia patients, demonstrate that is orthogonal surface marker expression. Moreover, parameter identifies new functional pathological states previously undetected via alone. Our findings will contribute more precise definition based on their properties pave way for better understanding heterogeneity cells.
Language: Английский
Citations
7
Marine Drugs, Journal Year: 2024, Volume and Issue: 22(4), P. 152 - 152
Published: March 28, 2024
Microalgae are being recognized as valuable sources of bioactive chemicals with important medical properties, attracting interest from multiple industries, such food, feed, cosmetics, and medicines. This review study explores the extensive research on identifying microalgae, choosing best strains for nutraceutical manufacturing. It most recent developments in recovery formulation strategies creating stable, high-purity, quality end products various industrial uses. paper stresses significance using Life Cycle Analysis (LCA) a strategic tool which to improve entire process. By incorporating LCA into decision-making processes, researchers industry stakeholders can assess environmental impact, cost-effectiveness, sustainability raw materials several approaches. comprehensive strategy will allow effective techniques, turn promote sustainable practices developing microalgae-based products. offers detailed analysis compounds, strain selection methods, advanced processing incorporation LCA. serve resource experts interested utilizing microalgae producing medicinal properties.
Language: Английский
Citations
7
Sensors and Actuators Reports, Journal Year: 2024, Volume and Issue: 7, P. 100192 - 100192
Published: March 28, 2024
Nanoplasmonic sensing (NPS) is a comparatively new and powerful technique, which yet to achieve its full potential across various fields of sciences. The principle behind NPS localized surface plasmon resonance. has several advantages over traditional techniques when it comes selectivity, sensitivity, concentration analyte required, prohibitive costs involved. phenomenon exhibits at the resolution depth between two few tens nm, difficult in practice or expensive attain with modern microscopes. Additionally, label free technique can measure fast real-time interactions solid-liquid interface. This review highlights applications lipid research emerging field extracellular vesicles.
Language: Английский
Citations
7
Nutrition & Metabolism, Journal Year: 2024, Volume and Issue: 21(1)
Published: July 18, 2024
Abstract Background Natural compounds can positively impact health, and various studies suggest that they regulate glucose‒lipid metabolism by influencing short-chain fatty acids (SCFAs). This is key to maintaining energy balance normal physiological functions in the body. review explores how SCFAs glucose lipid natural modulate these processes through SCFAs. provides a healthier approach treating disorders future. Methods article reviews relevant literature on glycolipid from PubMed Web of Science Core Collection (WoSCC). It also highlights range compounds, including polysaccharides, anthocyanins, quercetins, resveratrols, carotenoids, betaines, modulation SCFA pathway. Results enrich SCFA-producing bacteria, inhibit harmful operational taxonomic unit (OTU) abundance intestinal transport rate gut microbiota affect content intestine. However, most have been conducted animals, lack clinical trials, involve fewer target More research needed support conclusions develop interventions. Conclusions are crucial for human health produced mainly via dietary fiber fermentation. Eating foods rich fruits, vegetables, tea, coarse foods, hinder bacterial growth promote beneficial proliferation, thus increasing levels regulating metabolism. By investigating pathway, novel insights directions glucolipid be provided.
Language: Английский
Citations
7