Common Sage (S. Officinalis)- A Natural Medicine and Its Health Benefits DOI

Sahar Imran,

Nofa Amjad,

Madiha Khan Niazi

et al.

Futuristic Biotechnology, Journal Year: 2024, Volume and Issue: unknown, P. 29 - 38

Published: Dec. 31, 2024

Common Sage (Salvia officinalis) belongs to the Labiatae/Lamiaceae family Indigenous Middle East and Mediterranean regions but today has been world-widely revolutionized. Salvia officinalis exhibited an extensive array of functionally bioactive chemical constituents that have employed in treatment multiple chronic health conditions under primarily research documenting its novel biological significance exploring revolutionary impacts on well-being revealing range pharmaceutical significance. These investigations demonstrated besides curing relatively mild illnesses, S. possesses potentially natural remedial alleviating health-related life-threatening by possessing anti-carcinogenic, anti-depressive, anti-diabetic efficacy. This review will shed light pharmaco-medicinal properties signifying anti-oxidative, immune-modulatory, anti-tumor, anti-hyperlipidemic, Neuro-cognitive efficacy, Microbicide activities, toxicological effects preserve restore highlighting this plant as a fantastic herb with multi-factorial wellness benefits.

Language: Английский

Crosstalk between ROS-inflammatory gene expression axis in the progression of lung disorders DOI
Sumel Ashique, Neeraj Mishra, Shubhrajit Mantry

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

Language: Английский

Citations

10
MicroRNAs modulation in lung cancer: exploring dual mechanisms and clinical prospects DOI Open Access
Shahid Hussain,

Habib Bokhari,

Xing‐Xing Fan

et al.

Biocell, Journal Year: 2024, Volume and Issue: 48(3), P. 403 - 413

Published: Jan. 1, 2024

The global incidence of lung cancer is marked by a considerably elevated mortality rate.MicroRNAs (miRNAs) exert pivotal influence in the intricate orchestration gene regulation, and their dysregulation can precipitate dire consequences, notably cancer.Within this context, miRNAs encapsulated exosomes manifest diversified impact on landscape cancer, wherein actions may either foster angiogenesis, cell proliferation, metastasis, or counteract these processes.This comprehensive review article discerns potential targets for prospective development therapeutic agents tailored cancer.Tumor-suppressive miRNAs, such as miR-204, miR-192, miR-30a, miR-34a, miR-34b, miR-203, miR-212, exhibit heightened expression demonstrate capacity to inhibit cellular proliferation invasiveness.Conversely, deleterious effects tumor-promoting like miR-21, miR-106a, miR-155, miR-205, miR-210 be attenuated through application respective inhibitors.Distinct selectively target various oncogenes, including NUAK Family Kinase 1 (NUAK1), Snail Transcriptional Repressor (Snai1), Astrocyte gene-1 (AEG-1), Vimentin, Proliferation apoptosis adaptor protein 15 (PEA-15/PED), Hypoxia-inducible factor 1-alpha (HIF1), well tumor suppressor genes phosphatase tensin homolog (PTEN), Suppressor cytokine signaling (SOCS1), Tumor P53 binding (TP53BP1), PH Domain Leucine Rich Repeat Protein Phosphatase 2 (PHLP22).This investigative approach proves invaluable elucidating specific implicated deregulation crucial pathogenesis cancer.

Language: Английский

Citations

6
Nutritional Composition, Phytochemical Profile, Therapeutic Potentials, and Food Applications of Rosemary: A Comprehensive Review DOI
Amar Shankar, Abid Ali,

Hafiz Muhammad Abdullah

et al.

Journal of Food Composition and Analysis, Journal Year: 2024, Volume and Issue: 135, P. 106688 - 106688

Published: Aug. 28, 2024

Language: Английский

Citations

4
Evaluating the Anticancer Effects of Carnosic Acid Against Breast Cancer: An In Vitro Investigation DOI

Aylar Borhan,

Ali Bagherlou,

Mohammad B Ghayour

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: 93, P. 102718 - 102718

Published: Jan. 4, 2025

Language: Английский

Citations

0
Kwas Karnozynowy w Nowotworzeniu: od Teorii do Praktyki DOI Creative Commons

Magdalena Wojtczuk,

Agnieszka Dominiak

Prospects in Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 23(1), P. 80 - 88

Published: Feb. 27, 2025

W obliczu stale rosnącej liczby przypadków rozpoznania nowotworów na świecie wzrasta pilna potrzeba opracowania skutecznych metod zapobiegania i terapii przeciwnowotworowej. Warto zauważyć, że około 50% wszystkich leków klinicznych pochodzi ze źródeł naturalnych, co sprawia, fitochemikalia stają się obiecującą propozycją. Jednym z potencjalnych kandydatów jest kwas karnozowy, fenolowy związek diterpenoidowy, który obficie występuje w rozmarynie (Rosmarinus officinalis L.). ciągu ostatniej dekady znacząco wzrosła liczba badań in vitro vivo dotyczących aktywności biologicznej kwasu karnozowego jego pochodnych. Udowodniono, karnozowy wzmacnia obronę antyoksydacyjną, hamuje aktywność enzymów proteolitycznych, blokuje przejście nabłonkowo-mezenchymalne, zmniejsza przyleganie migrację komórek, a także zapobiega inwazji przerzutom guza. Ponadto, promuje śmierć komórek nowotworowych drodze apoptozy autofagii. Jego skuteczność chemoprewencji, antyproliferacyjnym antyinwazyjnym działaniu ludzkich liniach oraz syngenicznych modelach nowotworów, połączeniu efektami synergicznymi podczas stosowania skojarzonej, niskie koszty pozyskiwania stosunkowo łatwy dostęp potęgują potencjalne zastosowanie leczeniu raka. Jednak pomimo obiecujących wyników przedklinicznych, nadal brakuje walidacji klinicznej. Kilka kwestii wymaga dalszego zbadania, takich jak farmakokinetyka organizmach ludzkich, dostosowania dawkowania bezpieczny czas ekspozycji. Zanim będzie mógł być stosowany u pacjentów, niezbędna kompleksowa ocena bezpieczeństwa, uwzględniająca indywidualne profile metaboliczne. Żywność funkcjonalna zawierająca wydaje strategią pozwalającą zmniejszania globalnej zachorowalności raka, to jednak badania kliniczne wykorzystaniem onkologii wciąż są pełni uzasadnione.

Citations

0
Carnosic Acid: Perspectives on Contemporary Applications, Molecular Mechanisms, and Therapeutic Potential DOI

Monika Bansal,

Urmi Bhadouria,

S. C. Garg

et al.

Revista Brasileira de Farmacognosia, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Language: Английский

Citations

0
Delivery of Natural Small Molecules Through Nanocarriers for Cancer Treatment DOI Creative Commons

Fangting Ye,

Shaojie Zheng,

Shuo Shan

et al.

Food Frontiers, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

ABSTRACT Cancer is a formidable adversary, accounting for the second highest number of fatalities worldwide. A multitude studies have indicated that naturally sourced small‐molecule compounds, owing to their low toxicity and multi‐target capabilities, significantly aid in fight against tumorigenesis. However, natural small molecules certain limitations, such as poor water solubility permeability. These limitations curtail clinical potency result lower bioavailability within human body. To address these nano‐encapsulation techniques emerged promising strategy enhance solubility, stability, delivery compounds. For instance, several preclinical studies, encapsulating resveratrol liposomal nanocarriers increased its by up 50‐fold enhanced three five times. This work based on reports published from 1999 2024 PubMed ISI Web Science databases. review examines anticancer mechanisms key molecules, including polyphenols, alkaloids, terpenes, discusses how incorporation into nanocarrier systems improves efficacy. Additionally, this analysis provides comprehensive overview nanotechnology can overcome pharmacokinetic offering foundation future advancements cancer treatment.

Language: Английский

Citations

0
Beyond traditional uses: Unveiling the epigenetic, microbiome-modulating, metabolic, and nutraceutical benefits of Salvia officinalis in human and livestock nutrition DOI Creative Commons
Mohamed E. Abd El‐Hack, Hassan A. Rudayni, Ahmed Khalid Aldhalmi

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 128, P. 106843 - 106843

Published: April 25, 2025

Language: Английский

Citations

0
Natural compound screening predicts novel GSK-3 isoform-specific inhibitors DOI
Firdos Ahmad,

Anamika Gupta,

Hezlin Marzook

et al.

Biochimie, Journal Year: 2024, Volume and Issue: 225, P. 68 - 80

Published: May 7, 2024

Language: Английский

Citations

2
Advancements and Challenges in Artificial Intelligence Applications in Healthcare Delivery Systems DOI Open Access
Muhammad Nauman Aftab,

Alishba Nadeem,

Chengjuan Zhang

et al.

Published: July 12, 2024

The integration of Artificial Intelligence (AI) in healthcare has transformed clinical practices by improving the accuracy diagnosis, optimizing surgical procedures, patient experience, and accelerating drug development. This article provides a comprehensive overview many applications artificial intelligence across several industries, including fast diagnostics, where ML algorithms greatly enhance velocity disease diagnosis. State-of-the-art robotic-assisted minimally invasive procedures that shorten patients' hospitalization improve their chances recovery, cutting-edge AI monitoring, medication also looks at primary challenges will inevitably encounter, such as differences product quality, shortage skilled workers, privacy ethical issues, need for improved regulatory frameworks. Despite challenges, contributes significant advantages to industry, providing novel remarkable contributions efficiency medical progress outcomes. paper emphasizes importance cooperation overcoming current enhancing acceptability technology settings. ensure AI-driven innovations continue standards care.

Language: Английский

Citations

2