Open Chemistry,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Jan. 1, 2023
Abstract
Acanthophora
spicifera
harbors
a
diverse
array
of
secondary
metabolites
with
therapeutic
potential.
The
aim
this
study
is
to
isolate
and
characterize
from
A.
then
evaluate
the
antiproliferation,
antibacterial,
biofilm
prevention
properties,
followed
by
an
analysis
molecular
docking
experiments.
By
employing
chromatographic
NMR
spectroscopy,
isolated
compounds
were,
known
flavonol,
8-hydroxyquercetagetin
(
1
),
three
recognized
steroids
cholest-4-ene-3,6-dione
2
cholest-5-en-3β-ol
3
5α-cholestane-3,6-dione
4
2-bromohexadecanoic
acid
5
).
These
exhibited
antimicrobial
effects
against
various
Gram-negative
Gram-positive
bacteria
inhibition
zones
ranging
6.5
±
0.2
17.2
0.12
mm
7.0
0.4
15.3
0.60
mm,
respectively.
Compounds
inhibited
formation
in
P.
aeruginosa
S.
aureus
.
–
demonstrated
binding
affinity
values
between
−7.5
−9.4
kcal/mol
protein
1A0G.
were
akin
that
amoxicillin,
implying
one
potential
antibacterial
mechanism
action
these
may
involve
bacterial
cell
wall
synthesis.
All
showed
no
toxicity
Artemia
salina
weak
activity
Lymphoma
Lewis
lung
carcinoma
lines
LD
50
>
100
μg/mL.
Environmental Technology & Innovation,
Journal Year:
2024,
Volume and Issue:
35, P. 103729 - 103729
Published: June 26, 2024
The
interaction
between
microplastics
(MPs)
and
pollutants
is
crucial
for
assessing
the
environmental
risk
of
MPs.
It
necessary
to
pay
attention
adsorption/desorption
behavior
antibiotics
on
MPs
due
their
potential
role
in
antibiotic
resistance.
When
MPs-loaded
are
ingested
by
organisms,
they
enter
gastrointestinal
tract
undergo
desorption,
leading
corresponding
toxic
effects.
Existing
literature
primarily
focuses
adsorption
behavior,
while
there
a
lack
systematic
generalizations
desorption
or
combined
effects
organisms.
Therefore,
this
article
provides
review
mechanisms,
biological
tract.
Desorption
suggests
that
characteristics
(aging
hydrophobicity)
components
fluid
(digestive
enzyme
species
pH)
can
also
have
effect
desorption.
Moreover,
summarizes
induced
MPs-antibiotics,
demonstrating
either
enhance
reduce
plants,
microorganisms,
aquatic
animals.
Since
methodological
uniformity
relevance
natural
environment
main
shortcomings
existing
literature,
future
research
should
focus
actual
water
given
region
studying
at
gene,
protein,
metabolic
levels.
This
direction
expected
provide
valuable
references
insights
evaluating
antibiotics.
Results in Engineering,
Journal Year:
2024,
Volume and Issue:
21, P. 101836 - 101836
Published: Feb. 1, 2024
The
use
of
antibiotics
has
increased
in
the
last
five
years
due
to
COVID-19
pandemic,
which
led
an
increase
antibiotic
concentrations
wastewater.
Therefore,
there
is
a
need
for
implementation
technology
degradation.
This
research
aimed
determine
efficiency
advanced
oxidation
process
(AOP)
using
combination
UV/H2O2
degradation
was
conducted
amoxicillin
batch-wise
experiment.
Response
Surface
Methodology
with
Central
Composite
Design
(RSM-CCD)
employed
optimize
process.
result
revealed
that
rate
constants
and
were
0.0127/min
62.43
%,
respectively,
higher
than
UV
(0.0043/min
30.524
%)
or
H2O2
(0.0033/min
20.365
after
90
min
treatment.
optimum
solution
achieved
at
initial
pH
4.2,
concentration
45.85
mg/L,
10.093
mM.
Under
these
optimal
conditions,
could
reach
99.98
%.
In
addition,
results
study
demonstrate
inhibitory
effect
degraded
on
pathogenic
bacteria,
thus
indicating
photochemical
can
effectively
degrade
residues
showed
potential
be
effective
approach
Case Studies in Chemical and Environmental Engineering,
Journal Year:
2024,
Volume and Issue:
9, P. 100724 - 100724
Published: April 16, 2024
Highly
used
antibiotics,
such
as
amoxicillin
(AMX),
are
frequently
detected
in
the
aquatic
environment
due
to
contaminated
effluent
disposal,
alerting
for
possible
induction
of
antimicrobial
resistance.
In
this
study,
photodegradation
AMX
under
simulated
solar
radiation
and
environmental
influencing
factors
affecting
process
(pH,
salinity,
presence
humic
substances
or
reactive
oxygen
species
scavengers)
were
evaluated
further
understand
its
persistency
environment.
Photodegradation
was
shown
be
faster
at
higher
pH
(t1/2
=
21.0
±
0.6
h
8.0;
t1/2
8.0
0.3
9.0).
On
other
hand,
photolysis
slower
25.1
0.7
h)
high
salinity
(NaCl).
Through
use
•OH
1O2
scavengers
(propan-2-ol
(20
mmol
L−1)
sodium
azide
(5
L−1),
respectively),
it
concluded
that
main
pathway
phosphate
buffer
solution
(PBS)
is
indirect
via
•OH.
Freshwater
brackish
water
also
studied
evaluate
matrix
effects
on
photodegradation,
which
found
significantly
than
PBS
12.5
freshwater;
3.8
water;
PBS,
8.0).
