Nutrition and Diabetes,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: April 16, 2025
Ketogenic
conditions
have
gained
attention
due
to
their
favorable
metabolic
prognoses.
We
aimed
investigate
the
association
between
blood
levels
of
beta-hydroxybutyrate
(βHB),
most
abundant
form
ketone
body,
and
type
2
diabetes
(T2D)
incidence
in
patients
with
impaired
fasting
glucose
(IFG).
randomly
selected
500
IFG
from
prospective
Korean
Cancer
Prevention
Study
II
biobank.
Blood
βHB
were
measured
stored
samples,
diagnostic
data
National
Health
Insurance
Service
used
determine
probability
T2D-free
survival.
A
multivariable
Cox
regression
analysis
was
performed
assess
new-onset
T2D.
total
453
included,
105
(23%)
developed
T2D
during
a
mean
follow-up
period
10.9
years.
Higher
associated
improved
survival,
although
it
not
statistically
significant
(log-rank
test,
p
=
0.058).
In
models,
showed
tendency
toward
lower
risk
T2D,
but
(HR
0.70;
95%
CI
0.47-1.04;
0.07).
IFG,
level
be
T2D;
however,
this
significant.
npj Parkinson s Disease,
Journal Year:
2023,
Volume and Issue:
9(1)
Published: Jan. 27, 2023
There
is
growing
evidence
that
patients
with
type
2
diabetes
mellitus
(DM)
have
an
increased
risk
of
developing
Parkinson's
disease
(PD)
and
share
similar
dysregulated
pathways.
We
aimed
to
determine
whether
the
PD
increases
as
progresses
among
DM.
Using
a
nationally
representative
database
from
Korean
National
Health
Insurance
System,
2,362,072
individuals
(≥40
years
age)
DM
who
underwent
regular
health
checkups
during
2009-2012
were
followed
up
until
end
2018.
The
severity
score
parameters
included
number
oral
hypoglycemic
agents,
duration,
insulin
use,
or
presence
chronic
kidney
disease,
diabetic
retinopathy,
cardiovascular
disease.
Each
these
characteristics
was
scored
one
unit
their
sum
defined
0-6.
identified
17,046
incident
cases
follow-up.
component
showed
intensity
for
PD.
Compared
subjects
no
parameters,
HR
values
(95%
confidence
intervals)
1.09
(1.04-1.15)
in
parameter,
1.28
(1.22-1.35)
two
1.55
(1.46-1.65)
three
1.96
(1.82-2.11)
four
2.08
(1.83-2.36)
five
2.78
(2.05-3.79)
six
parameters.
Diabetes
associated
Severe
may
be
factor
development
Endocrinology and Metabolism,
Journal Year:
2023,
Volume and Issue:
38(1), P. 10 - 24
Published: Feb. 9, 2023
The
Korean
National
Health
Information
Database
(NHID)
contains
big
data
combining
information
obtained
from
the
Insurance
Service
and
health
examinations.
Data
are
provided
in
form
of
a
cohort,
NHID
can
be
used
to
conduct
longitudinal
studies
research
on
rare
diseases.
Moreover,
cause
date
death
by
Statistics
Korea.
Research
publications
based
have
increased
explosively
field
endocrine
disorders.
However,
because
were
not
collected
for
purposes,
using
limitations,
particularly
need
operational
definition
In
this
review,
we
describe
characteristics
NHID,
definitions
diseases
research,
an
overview
recent
endocrinology
NHID.
Diabetes & Metabolism Journal,
Journal Year:
2023,
Volume and Issue:
47(3), P. 347 - 355
Published: March 29, 2023
This
study
investigated
the
changes
of
fatty
liver
disease
prevalence
in
general
Korean
population.This
analyzed
data
from
National
Health
Insurance
Service
2009
to
2017
that
included
individuals
aged
20
years
or
older
who
had
undergone
a
medical
health
examination.
Fatty
was
assessed
using
index
(FLI).
The
severity
defined
by
FLI
cutoff,
≥30
as
moderate,
and
≥60
severe
disease.The
adults
over
with
(FLI
≥60)
increased
13.3%
15.5%
(P
for
trend
<0.001).
increase
prominent
men
(from
20.5%
24.2%)
young
age
(20
39
years)
group
12.8%
16.4%)
interaction
highest
type
2
diabetes
mellitus
(T2DM,
29.6%)
population
compared
prediabetes
normoglycemia
(10.0%
21.8%)
2017.
statistically
T2DM
Its
more
steeply
young-aged
T2DM,
42.2%
60.1%
When
applying
lower
cutoff
(≥30)
similar
results
were
observed.The
has
increased.
Individuals
are
young,
male,
have
vulnerable
disease.
Diabetes & Metabolism Journal,
Journal Year:
2025,
Volume and Issue:
49(1), P. 13 - 21
Published: Jan. 1, 2025
The
Korean
National
Health
Information
Database
(NHID),
which
contains
nationwide
real-world
claims
data
including
sociodemographic
data,
health
care
utilization
screening
and
healthcare
provider
information,
is
a
powerful
resource
to
test
various
hypotheses.
It
also
longitudinal
in
nature
due
the
recommended
checkup
every
2
years
appropriate
for
long-term
follow-up
study
as
well
evaluating
relationships
between
outcomes
changes
parameters
such
lifestyle
factors,
anthropometric
measurements,
laboratory
results.
However,
because
these
are
not
collected
research
purposes,
precise
operational
definitions
of
diseases
required
facilitate
big
analysis
using
NHID.
In
this
review,
we
describe
characteristics
NHID,
used
related
diabetes,
introduce
representative
diabetes-related
Mayo Clinic Proceedings,
Journal Year:
2025,
Volume and Issue:
100(2), P. 235 - 248
Published: Jan. 11, 2025
To
assess
the
comparative
effectiveness
of
sodium-glucose
cotransporter
2
inhibitors
(SGLT2i),
thiazolidinediones
(TZD),
and
dipeptidyl
peptidase-4
(DPP-4i)
for
cardiorenal
outcomes
mortality
in
individuals
with
type
diabetes
a
prior
stroke.
Using
Korean
National
Health
Insurance
Service
database
from
2014
to
2021,
new-user
cohort
was
established
through
propensity
score
matching
SGLT2i,
TZD,
DPP-4i.
The
primary
were
major
adverse
cardiovascular
events
(MACE),
comprising
myocardial
infarction,
ischemic
stroke,
death.
Secondary
included
individual
components
MACE,
hospitalization
heart
failure,
composite
kidney
outcome,
all-cause
mortality.
Weighted
Cox
proportional
hazard
models
used
calculate
HRs
95%
CIs.
Among
9733
participants
(mean
age,
67.2±3.2
years;
46.8%
women),
incidence
rate
MACE
220,
202,
251
per
1000
person-years
DPP-4i
groups.
SGLT2i
(HR,
0.86;
CI,
0.77
0.97;
P=.01)
TZD
0.80;
0.70
0.90;
P<.001)
showed
lower
risk
compared
Importantly,
no
significant
difference
observed
between
TZD.
associated
reduced
death,
whereas
risks
use
people
stroke
DPP-4i,
variations
effects
on
outcomes.
ABSTRACT
Background
and
Aims
This
study
investigated
the
long‐term
prognosis
clinical
course
of
patients
who
survived
for
more
than
5
years
after
hepatocellular
carcinoma
(HCC)
diagnosis.
Methods
retrospective
cohort
used
data
from
Korean
National
Health
Insurance
Service
database.
A
total
35,348
subjects
newly
diagnosed
with
HCC
between
January
2008
December
2010
were
followed
up
until
2018.
Results
11,514
(32.6%)
diagnosis
among
HCC.
Long‐term
survivors
(≥
years)
had
a
higher
proportion
females,
younger
age,
frequent
aetiology
hepatitis
B
virus,
less
liver
cirrhosis,
diabetes
mellitus
hypertension,
received
curative
treatment
frequently
nonsurvivors
(<
years).
The
additional
1‐,
3‐
5‐year
cumulative
survival
probabilities
90.7%,
77.6%
68.4%
respectively.
Patients
underwent
as
first
showed
those
treated
noncurative
therapy
(74.5%
vs.
64.2%).
Among
survivors,
44.4%
retreatment
probability
was
54.9%
in
group.
overall
5‐
10‐year
second
primary
malignancies
15.36%
27.54%
most
malignancy
prostate
cancer,
by
colorectal
pancreatic
cancers.
Conclusion
Our
highlights
that
significant
achieve
beyond
years,
favourable
outcomes
associated
treatments.
Journal of Korean Medical Science,
Journal Year:
2025,
Volume and Issue:
40(8)
Published: Jan. 1, 2025
The
National
Health
Insurance
Service
(NHIS)
database
serves
as
a
crucial
resource
for
public
health
research
in
Korea.
As
comprehensive
dataset
within
the
single-payer
healthcare
system,
NHIS
data
provides
longitudinal
insights
into
utilization,
disease
prevalence,
and
outcomes.
This
review
article
explores
structure,
characteristics,
applications
of
data,
emphasizing
its
role
epidemiological
studies,
policy
evaluations,
clinical
research.
We
discuss
key
methodological
considerations,
including
access
procedures,
outcome
measures,
strategies
to
mitigate
bias.
Additionally,
we
highlight
future
directions,
such
integrating
with
other
national
datasets
utilizing
artificial
intelligence
predictive
analytics.
By
leveraging
database,
researchers
can
enhance
evidence-based
policymaking
improve
outcomes
The Journal of Clinical Endocrinology & Metabolism,
Journal Year:
2024,
Volume and Issue:
109(12), P. e2317 - e2323
Published: Feb. 15, 2024
Abstract
Objective
To
investigate
the
association
of
diabetes
duration
with
cardiovascular
disease
(CVD)
risk
and
to
examine
relationship
between
lipid
levels
CVD
over
duration.
Methods
Using
Korean
National
Health
Insurance
Service
Cohort
database,
we
identified
2
359
243
subjects
type
aged
≥
20
years
in
2015
2016.
Baseline
were
evaluated
followed
up
until
December
2020
(mean
follow-up,
3.9
years).
Subjects
categorized
according
(new-onset,
<
5
years,
5-9
or
10
We
analyzed
new-onset
group
low-density
lipoprotein
cholesterol
(LDL-C)
70
mg/dL
as
reference
group.
The
hazard
ratios
(HRs)
95%
CIs
myocardial
infarction
(MI)
ischemic
stroke
(IS)
estimated
using
a
Cox
proportional
hazards
model
adjusted
for
potential
confounders.
Results
During
45
883
cases
MI
53
538
IS
identified.
began
increase
at
LDL-C
160
group,
130
years.
Among
9
100-129
mg/dL,
130-159
significantly
associated
(HR
[95%
CI]
1.13
[1.04-1.22],
1.28
[1.17-1.39],
1.58
[1.42-1.76],
respectively).
was
increased
by
16%,
even
70-99
population
1.16
[1.08-1.25]).
Conclusion
This
population-based
longitudinal
study
revealed
that
cutoff
level
increasing
varied
target
should
depend
on
