Higher dietary live microbe intake is associated with a lower risk of sarcopenia

Clinical Nutrition, Journal Year: 2024, Volume and Issue: 43(7), P. 1675 - 1682

Published: May 23, 2024

This study aimed to investigate the potential association between dietary live microbe intake and sarcopenia.

Language: Английский

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Impact of socioeconomic status on utilisation of a Virtual Emergency Department: An exploratory analysis

Emergency Medicine Australasia, Journal Year: 2025, Volume and Issue: 37(1)

Published: Feb. 1, 2025

Abstract Objective To explore whether utilisation of a Virtual Emergency Department (VVED) differs according to socioeconomic status (SES). Methods A retrospective analysis was undertaken data from the VVED – telehealth service that provides care for patients across Victoria, Australia with non‐life‐threatening emergencies. The study included all individuals who presented between July 2022 and June 2023 through two most common referral pathways (self‐referral ambulance referral). Area‐level SES ascertained by matching residential postcodes corresponding Australian Bureau Statistics (ABS) Index Relative Socioeconomic Advantage Disadvantage (IRSAD) decile. IRSAD scores were divided into quintiles (1 = lowest SES, 5 highest SES) multivariable logistic regression modelling used analyse associations quintile pathway, as odds ratios (ORs) 95% confidence intervals (CIs). Results There 68 598 participants in analyses (mean age: 36.6 years; 58.4% female). Compared 3, higher self‐referral observed advantaged groups (Quintile 4; adjusted OR [aOR] 1.16; CI: 1.06–1.26; P 0.001) 5; aOR 1.38; 1.25–1.52; < 0.001). Conversely, lower disadvantaged group 1; 0.82; 0.75–0.90; Conclusions present demonstrated relatively even population groups. use healthcare provider pathways, such paramedics, may increase equitable access telehealth. Clinical attention should be directed toward specific social emergency setting.

Language: Английский

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Unraveling the dual threat: sarcopenia and insufficient physical activity in diabetes risk

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 8, 2025

This study aimed to investigate the alterations in diabetes risk associated with sarcopenia and insufficient physical activity, as well demographic shifts within diabetic population. Utilizing pertinent data from National Health Nutrition Examination Survey (NHANES) database spanning 2011 2018, criteria for were established by Foundation Institutes of Health. These calculated using lean body mass conjunction index data. Physical activity levels assessed PAQ questionnaire NHANES database. The presence was determined through DIQ laboratory examination analysis performed multivariable logistic regression. prevalence both population 188% greater than non-diabetic Sarcopenia positively correlated an increased onset, demonstrating a 1.45-fold heightened when conditions present (OR=2.45,95%CI,1.35-4.44,P<0.05). combined effect significantly alone (OR=1.84,95%CI,1.09-3.11,P<0.05) or (OR=1.55,95%CI,1.11-2.15,P<0.05). A synergistic relationship exists between resulting markedly elevated are concurrently. Therefore, comprehensive management strategies should prioritize populations exhibiting activity.

Language: Английский

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Molecular insights into Parkinson's disease and type 2 diabetes mellitus: Metformin's role and genetic pathways explored

Experimental Neurology, Journal Year: 2025, Volume and Issue: 385, P. 115137 - 115137

Published: Jan. 10, 2025

Language: Английский

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Relationship between Muscle Mass by Bioimpedance and Vascular Complications in Type 2 Diabetes Mellitus

Salud Ciencia y Tecnología, Journal Year: 2025, Volume and Issue: 4

Published: Jan. 15, 2025

Introduction. Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by elevated glucose levels, which over time can cause severe vascular complications such as retinopathy, neuropathy, nephropathy, and cerebrovascular accident (CVA). Body composition, particularly lean mass, fat-free skeletal muscle mass key factor in preventing these complications. This study evaluated the relationship between body measured bioimpedance, T2DM patients. Methods. A quantitative, correlational, multivariate was conducted with 88 patients aged 18 to 90 years from clubs province of Tungurahua. Bioimpedance (Inbody S10) used measure composition. Data were analyzed using descriptive statistics, Pearson correlation, principal component analysis SPSS.Results. The results showed that decreased significantly age, correlates higher risk Skeletal had weaker correlation complications, especially case retinopathy. Microvascular neuropathy more related mass. Conclusions. Preserving are critical factors for reducing Physical exercise proper nutrition suggested maintain healthy older adults, strategy prevent microvascular macrovascular

Language: Английский

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Sarcopenia and Type 2 Diabetes Mellitus: Evaluation, Pathophysiological Links, and Management Strategies

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Sarcopenia refers to the rapid loss of skeletal muscle mass and strength, which can result in serious consequences such as falls, fractures, a higher risk mortality. The prevalence sarcopenia is observed be twice high individuals with type 2 diabetes mellitus. Notably, there bidirectional relationship between mellitus, where each condit‑‑ion exacerbate progression other. Overlapping pathophysiological mechanisms, insulin resistance, inflammation, oxidative stress, accumulation advanced glycation end products, mitochondrial dysfunction, myosteatosis, aging process itself contribute development both conditions. A few treatments, myostatin antagonists, testosterone supplementation, selective androgen receptor modulators have been explored, but many remain experimental or clinical trial stages. cornerstone management involves nutritional intervention foods rich protein, essential amino acids, vitamin D, omega-3 fatty acids. Additionally, incorporating regular physical activity, particularly resistance exercises, minimizing sedentary behavior are key components for sarcopenia.

Language: Английский

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Risk factors for sarcopenia in community setting across the life course: A systematic review and a meta-analysis of longitudinal studies

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: 133, P. 105807 - 105807

Published: March 1, 2025

Language: Английский

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Development and validation of a predictive model for the risk of possible sarcopenia in middle-aged and older adult diabetes mellitus in China

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: April 3, 2025

People with diabetes mellitus (DM) have a significantly increased risk of sarcopenia. A cross-sectional analysis was performed using nationally representative data to evaluate possible sarcopenia in middle-aged and older adults mellitus, develop validate prediction model suitable for the Chinese community. Data from China Health Retirement Longitudinal Study (CHARLS), which focuses on people 45 years age or older, served as basis model. CHARLS 2015 participants were used study, examined 53 factors. In order guarantee reliability, study split into two groups at random: 70% training 30% validation. Ten-fold cross-validation Least Absolute Shrinkage Selection Operator (LASSO) regression analyses determine best predictors The factors associated DM researched logistic models. Nomogram constructed predictive performance assessed area under curve (AUC), calibration curves decision (DCA). total 2,131 database collected passed final analysis, prevalence 28.9% (616/2131). Eight subsequently chosen models by LASSO regression: age, residence, body mass index, diastolic blood pressure, cognitive function, activities daily living, peak expiratory flow hemoglobin. These nomogram model, showed good accuracy agreement. AUC values validation sets 0.867 (95%CI: 0.847~0.887) 0.849 0.816~0.883). Calibration DCA indicated that exhibited performance. this can be probability adult DM, is helpful early identification intervention high-risk groups.

Language: Английский

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Primary Hyperparathyroidism: An Analysis Amid the Co-Occurrence of Type 2 Diabetes Mellitus

Life, Journal Year: 2025, Volume and Issue: 15(4), P. 677 - 677

Published: April 21, 2025

Background: Apart from classical elements in primary hyperparathyroidism (PHPT), non-classical complications, including type 2 diabetes mellitus (T2DM), are reported some patients, but currently, they do not represent a parathyroidectomy (PTx) indication. Objective: to explore the latest data regarding glucose profile, particularly, T2DM and metabolic syndrome (MetS) PHPT, post-PTx. Methods: PubMed-based review included English-published original studies between January 2020 December 2024 (n = 20). Results: Studied population: 764,485 subjects (female-to-male ratio of 1.26:1; 23,931 were PHPT patients vs. 740,502 controls). prevalence 13; N 763,645 patients; 55.92% females): 4–60% (higher controls); for largest study (N 699,157) 31.3%. Age-based analysis: higher at >50 <50 years (14.4% 2.6%, p < 0.001), all agreed. Concurrent vitamin D deficiency as contributor risk had limited evidence. The association MetS-PHPT 2) no clear conclusion. Post-PTx showed following: lower glycaemia, fasting insulin, insulin resistance (HOMA-IR) improvement, reduced rate (but agreed). with prediabetes might population sub-group highest post-PTx benefit. Conclusions: panel PHPT-T2DM interplay remains heterogeneous. Data improvement disorders still conflicting, recent findings suggested that surgery has beneficial effects, especially confirmed pre-existing prediabetes. Patients normocalcemic variant seemed be less affected by glucose-related disturbances, further needed. A better understanding intricate relationship metabolism anomalies will help providing optimal management reduce overall disease burden.

Language: Английский

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Higher body mass index increases the risk of shoulder adhesive capsulitis in young adults: A nationwide cohort study

Journal of Shoulder and Elbow Surgery, Journal Year: 2024, Volume and Issue: 34(1), P. 26 - 32

Published: May 27, 2024

Language: Английский

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