Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(49), P. 19220 - 19229
Published: Nov. 27, 2024
Vanadate
has
become
an
important
indicator
for
environmental
testing
due
to
its
high
toxicity,
mobility,
and
difficulty
in
degradation.
In
addition,
depending
on
dynamic
aggregation,
analyzing
vanadate
is
not
a
single
content
test;
it
needs
further
morphological
analysis.
Previous
research
tended
construct
functional
platform
with
complicated
procedures
expensive
equipment,
making
difficult
obtain
comprehensive
picture
of
short
time.
Herein,
we
constructed
dual-response
fluorescent
probe
EuTAT@Rh
B
formed
by
Eu
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(10)
Published: Jan. 10, 2024
Giant
heterometallic
polyoxometalate
(POM)
clusters
with
precise
atom
structures,
flexibly
adjustable
and
abundant
active
sites
are
promising
for
constructing
functional
nanodrugs.
However,
current
POM
drugs
almost
vacant
in
orthotopic
brain
tumor
therapy
due
to
the
inability
effectively
penetrate
blood-brain
barrier
(BBB)
low
drug
activity.
Here,
we
designed
largest
(3.0
nm
×
6.0
nm)
transition-metal-lanthanide
co-encapsulated
cluster
{[Ce
Chemical Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 16, 2025
Vanadium
is
a
transition
metal
with
important
industrial,
technological,
biological,
and
biomedical
applications
widespread
in
the
environment
living
beings.
The
different
reactions
that
vanadium
compounds
(VCs)
undergo
presence
of
proteins,
nucleic
acids,
lipids
metabolites
under
mild
physiological
conditions
are
reviewed.
In
present
naturally
or
through
anthropogenic
sources,
latter
having
an
environmental
impact
caused
by
dispersion
VCs
atmosphere
aquifers.
has
versatile
chemistry
interconvertible
oxidation
states,
variable
coordination
number
geometry,
ability
to
form
polyoxidovanadates
various
nuclearity
structures.
If
VC
added
water-containing
it
can
hydrolysis,
ligand-exchange,
redox,
other
types
changes,
determined
speciation
vanadium.
Importantly,
solution
likely
differ
from
introduced
into
system
varies
concentration.
Here,
hydrolytic
ligand-exchange
chemical
reactions,
influence
pH,
concentration,
salt,
specific
solutes,
biomolecules,
on
described.
One
our
goals
this
work
highlight
need
for
assessment
speciation,
so
beneficial
toxic
species
might
be
identified
mechanisms
action
elucidated.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
17(1), P. 12 - 12
Published: Dec. 21, 2023
Repurposing
drugs
by
uncovering
new
indications
for
approved
accelerates
the
process
of
establishing
treatments
and
reduces
high
costs
drug
discovery
development.
Metal
complexes
with
clinically
allow
further
opportunities
in
cancer
therapy—many
vanadium
compounds
have
previously
shown
antitumor
effects,
which
makes
a
suitable
metal
to
complex
therapeutic
drugs,
potentially
improving
their
efficacy
treatment.
In
this
review,
covering
last
25
years
research
field,
we
identified
non-oncology-approved
as
ligands
obtain
different
complexes.
Metformin-decavanadate,
vanadium-bisphosphonates,
vanadyl(IV)
non-steroidal
anti-inflammatory
cetirizine
imidazole-based
oxidovanadium(IV)
complexes,
each
has
parent
known
medicinal
properties
indications,
all
showed
potential
novel
anticancer
treatments.
Nevertheless,
precise
mechanisms
action
these
against
are
still
not
fully
understood.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(10)
Published: Jan. 10, 2024
Abstract
Giant
heterometallic
polyoxometalate
(POM)
clusters
with
precise
atom
structures,
flexibly
adjustable
and
abundant
active
sites
are
promising
for
constructing
functional
nanodrugs.
However,
current
POM
drugs
almost
vacant
in
orthotopic
brain
tumor
therapy
due
to
the
inability
effectively
penetrate
blood–brain
barrier
(BBB)
low
drug
activity.
Here,
we
designed
largest
(3.0
nm
×
6.0
nm)
transition‐metal–lanthanide
co‐encapsulated
cluster
{[Ce
10
Ag
6
(DMEA)(H
2
O)
27
W
22
O
70
][B‐
α
‐TeW
9
33
]
}
88−
featuring
238
metal
centers
via
synergistic
coordination
between
two
geometry‐unrestricted
Ce
3+
+
linkers
tungsten‐oxo
fragments.
This
was
combined
brain‐targeted
peptide
prepare
a
nanodrug
that
could
efficiently
traverse
BBB
target
glioma
cells.
The
specifically
activate
reactive
oxygen
species
regulate
apoptosis
pathway
of
cells
half‐maximal
inhibitory
concentration
(5.66
μM).
As
first
drug,
it
prolongs
survival
glioma‐bearing
mice.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4982 - 4982
Published: May 3, 2024
This
Special
Issue
(SI),
”Emerging
Topics
in
Metal
Complexes:
Pharmacological
Activity”,
includes
reports
updating
our
knowledge
on
metals
with
multidirectional
biological
properties
and
metal-containing
compounds/complexes
for
their
potential
therapeutic
applications,
a
focus
strategies
improving
pharmacological
features
[...]
