The glutamatergic projections from the PVT to mPFC govern methamphetamine-induced conditional place preference behavior in mice DOI
Meiqin Wang, Lei Xu,

Di Zhao

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Oxytocin receptors within the caudal lateral septum regulate social approach-avoidance, long-term social discrimination, and anxiety-like behaviors in adult male and female rats DOI Creative Commons
Fardad Pirri, Cheryl M. McCormick

Neuropharmacology, Journal Year: 2025, Volume and Issue: 271, P. 110409 - 110409

Published: March 11, 2025

OTR signaling promotes social approach or facilitates avoidance, depending on the brain region involved. The lateral septum plays a critical role in regulating interactions and memory. We investigated of caudodorsal (LSc.d) modulating approach-avoidance behavior, long-term discrimination memory, anxiety-like behaviors adult rats. Local infusion selective antagonist L-368,899 (1 μg/0.5 μl) into LSc.d decreased approach, increased vigilance, reduced memory both sexes. Administration biased OTR/Gq agonist carbetocin (0.5 sexes, had anxiogenic effects (increased latency to consume palatable food test arena) only males. In contrast, full TGOT (50 ng/0.5 no effect (anxiolytic effect). results indicate that oxytocin system can promote inhibit differential activation G-protein subunits β-arrestins, as well pivotal LS behavior

Language: Английский

Citations

0
Somatostatin-expressing interneurons of prefrontal cortex modulate social deficits in the Magel2 mouse model of autism DOI Creative Commons

Xiaona Wang,

Mengyuan Chen,

Daoqi Mei

et al.

Molecular Autism, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 11, 2025

Dysfunction in social interactions is a core symptom of autism spectrum disorder (ASD). Nevertheless, the neural mechanisms underlying deficits ASD are poorly understood. By integrating electrophysiological, vivo fiber photometry, viral-mediated tracing, optogenetic and pharmacological stimulation, we show reduced intrinsic excitability hypoactivity SOM interneurons medial prefrontal cortex (mPFC) Magel2-deficient mice, an established model, were required to defects. Chemogenetic inhibition mPFC SOM-containing resulted interaction wild-type Magel2 mice. These sociability can be rescued by activation mPFCSOM-LS inhibitory pathway Magel 2 knockout results demonstrate for action impairments, suggest targeting this mechanism that may prove therapeutically beneficial mitigating behavioral disturbances observed ASD.

Language: Английский

Citations

0
Effects of Interleukin-19 overexpression in the medial prefrontal cortex on anxiety-related behaviors, BDNF expression and p38/JNK/ERK pathways DOI Creative Commons
Yuting Jiang, Lihong Xu,

Yifan Cao

et al.

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 212, P. 110952 - 110952

Published: April 16, 2024

Anxiety is a prevalent mental illness known for its high incidence, comorbidity, and tendency to recur, posing significant societal individual burdens. Studies have highlighted Interleukin-19 (IL-19) as having potential relevance in neuropsychiatric disorders. Our previous research revealed that IL-19 overexpression colonies exacerbated anxiety-related behaviors induced by dextran sodium sulfate/stress. However, the precise role molecular mechanisms of anxiety regulation remain uncertain. In this study, we initiated an acute restraint stress (ARS)-induced anxious mouse model identified heightened expression IL-20Rα medial prefrontal cortex (mPFC) ARS mice. Notably, were predominantly present excitatory pyramidal neurons mPFC under both basal conditions. Utilizing adeno-associated virus (AAV) strategy, demonstrated elevated susceptibility. Additionally, observed decreased protein levels brain-derived neurotrophic factor (BDNF) postsynaptic density 95 (PSD95) mice, accompanied reduced phosphorylation p38, JNK, Erk signaling pathways. These findings emphasize modulating within suggest pathological gene therapeutic target anxiety.

Language: Английский

Citations

3
Dorsal raphe dopaminergic neurons target CaMKII+ neurons in dorsal bed nucleus of the stria terminalis for mediating depression-related behaviors DOI Creative Commons
Wentao Wang, Dan Wang,

Di Zhao

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 2, 2024

Language: Английский

Citations

2
Interleukin-11Rα2 in the hypothalamic arcuate nucleus affects depression-related behaviors and the AKT-BDNF pathway DOI
Mengyu Yang,

Shulei Tian,

Xiaofeng Han

et al.

Gene, Journal Year: 2024, Volume and Issue: 933, P. 148966 - 148966

Published: Sept. 26, 2024

Language: Английский

Citations

0
The glutamatergic projections from the PVT to mPFC govern methamphetamine-induced conditional place preference behavior in mice DOI
Meiqin Wang, Lei Xu,

Di Zhao

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

0