World Journal of Advanced Research and Reviews,
Journal Year:
2023,
Volume and Issue:
20(3), P. 532 - 539
Published: Dec. 11, 2023
Background:
Halitosis
is
unpleasant
odors
originating
from
the
oral
cavity
caused
by
metabolic
waste
of
periodontopathogens
bacteria
in
form
volatile
sulphur
compounds
(VSCs).
According
to
Riskesdas
2018,
health
prevalence
Indonesia
reached
57.6%.
Doctors
recommend
using
a
mouthwash
made
chlorhexidine.
However,
it
less
effective
because
can
cause
various
side
effects.
The
alternative
treatments
herbal
ingredients
pomegranate.
This
literature
review
aim
analyze
potential
and
mechanism
pomegranate
as
an
halitosis
therapy
against
bacteria.
Material
Methods:
was
carried
out
PUBMED,
ResearchGate,
ScienceDirect
with
keywords:
pomegranate,
mouthwash,
anti-bacteria,
halitosis.
Conclusions:
Pomegranate
has
be
inhibiting
plaque
formation
growth
Pathogens,
Journal Year:
2025,
Volume and Issue:
14(2), P. 162 - 162
Published: Feb. 7, 2025
Sustainable
agricultural
practices
increasingly
focus
on
natural
bioactive
agents
for
managing
phytopathogens.
This
study
investigates
the
antifungal
and
phytotoxic
properties
of
methanolic
bioextracts
derived
from
Plantago
major
leaves
(MBPm)
Sambucus
nigra
roots
(MBSn)
to
explore
their
potential
applications.
Bioextracts
were
prepared
through
maceration,
with
yields
6.02%
(P.
major)
6.42%
(S.
nigra).
Antifungal
assays
evaluated
inhibitory
effects
Fusarium
oxysporum,
Corynespora
cassiicola,
Penicillium
oxalicum,
while
phytotoxicity
assessed
concentration-dependent
impacts
Solanum
lycopersicum
seed
germination.
A
qualitative
evaluation
polyphenolic
compounds
was
conducted
using
Ultra-Performance
Liquid
Chromatography
coupled
a
Photodiode
Array
Detector
Electrospray
Ionization
Mass
Spectrometry
(UPLC-PDA-ESI-MS)
identify
known
significant
biological
activity.
P.
demonstrated
inhibition
F.
oxysporum
(90.06%)
C.
cassiicola
(83.19%),
S.
achieved
89.65%
92.16%
inhibition,
respectively.
Both
showed
minimal
impact
observed
only
at
50
mg/mL.
Low
concentrations
bioextract
enhanced
germination,
whereas
higher
doses
inhibited
it.
Identified
included
acteoside,
isoacteoside,
chlorogenic
acid,
dicaffeoylquinic
acid
isomers.
The
findings
highlight
these
as
biocontrol
modulators
germination
processes,
contributing
sustainable
strategies.
While
this
under
controlled
laboratory
conditions,
results
provide
strong
foundation
future
evaluations
in
field
settings
broader
International journal of Nutrition Pharmacology Neurological Diseases,
Journal Year:
2025,
Volume and Issue:
15(1), P. 18 - 25
Published: Jan. 1, 2025
Background:
The
objective
of
treating
periodontal
disease
is
to
inhibit
or
eliminate
pathogens
through
mechanical
debridement,
supplemented
by
local
antibiotics.
Nonetheless,
these
antibiotics
can
trigger
side
effects.
Hence,
herbal
products
have
emerged
as
popular
supplements
debridement.
Methodology:
This
a
parallel-group
study
in
which
20
patients
(40
sites)
were
divided
into
test
and
control
groups.
They
treated
with
8%
“
Ocimum
sanctum
gel
for
drug
delivery
along
scaling
root
planing
(SRP)
SRP
alone,
respectively.”
Subgingival
plaque
samples
collected,
was
performed,
O.
applied
the
group.
“Probing
pocket
depth
(PPD),
relative
attachment
level
(RAL),
plaque,
gingival,
gingival
bleeding
indices”
colony
counts
Aggregatibacter
actinomycetemcomitans
Porphyromonas
gingivalis
assessed
at
baseline,
1,
3
months.
Results:
groups
demonstrated
significant
reduction
PPD,
decreasing
from
6.40
±
0.516
2.6
0.483
mm,
gain
RAL
8.4
4.60
mm.
Additionally,
A.
P.
exhibited
31.15
2.51
10.75
2.24
cfu/mL
50.40
4.66
22.70
3.74
cfu/mL,
respectively.
At
months,
group
superior
improvements
all
parameters
compared
(
P
<
0.001).
However,
reductions
index
not
statistically
intergroup
comparisons
>
Conclusion:
Based
on
clinical
results
microbiological
findings,
proves
be
an
effective
adjunct
standard
therapy.
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(3), P. 409 - 409
Published: March 14, 2025
Green
tea
(Camellia
sinensis)
exhibits
significant
potential
in
oral
health
due
to
its
antioxidant,
anti-inflammatory,
and
antimicrobial
properties.
This
review
explores
role
managing
periodontal
disease,
a
common
condition
characterized
by
inflammation,
microbial
imbalances,
tissue
destruction.
The
primary
bioactive
components,
particularly
epigallocatechin-3-gallate
(EGCG),
contribute
green
tea’s
therapeutic
effects
inhibiting
bacterial
adhesion,
modulating
inflammatory
pathways,
reducing
oxidative
stress.
Clinical
studies
suggest
improves
pocket
depth,
bleeding.
It
can
serve
as
an
adjunct
conventional
therapies,
including
scaling
root
planing,
be
incorporated
into
care
products
such
mouthwashes
dentifrices.
Furthermore,
presents
natural
alternative
chemical
agents
like
chlorhexidine,
potentially
mitigating
side
addressing
concerns
about
antibiotic
resistance.
However,
efficacy
remains
moderate
compared
established
treatments,
highlighting
the
need
for
further
research
optimize
formulation
applications.
represents
sustainable
biocompatible
approach
therapy,
supporting
integration
preventive
strategies.
Applied Sciences,
Journal Year:
2025,
Volume and Issue:
15(7), P. 3704 - 3704
Published: March 27, 2025
Natural
toothpastes
were
introduced
to
limit
the
use
of
chemical
ingredients
commonly
found
in
conventional
toothpastes.
The
purpose
this
vitro
study
was
evaluate
antimicrobial
properties
three
developed
natural
containing
different
agents:
(a)
Biosecur
Organic
Oral
Care
(BOOC),
(b)
Microsilver
BG,
and
(c)
Cranberry
LG.
These
compared
with
a
toothpaste
same
composition
but
without
any
added
agent
(negative
control),
as
well
commercial
synthetic
(positive
control).
assessed
using
disc
diffusion
test
against
oral
pathogens:
Candida
albicans,
Streptococcus
mutans,
Prevotella
intermedia.
Each
tested
sample
placed
Petri
dishes,
where
specific
microorganisms
selected
for
cultivated.
After
incubation,
circular
area
formed
around
discs
(diameter),
known
inhibition
zone,
measured
demonstrating
inhibitory
effect
product
on
used
efficacy
test.
All
experimental
exhibited
higher
negative
control
group,
except
only
BOOC-containing
presented
significant
zones
(p
<
0.001).
Considering
outcomes
property
test,
most
effective
one,
which
showed
better
behavior
even
from
commercially
available
agents
enhancing
that
included,
especially
agent.
Journal of drug targeting,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 60
Published: Dec. 19, 2024
Periodontitis
(PD)
is
a
chronic
gum
illness
that
may
be
hard
to
cure
for
number
of
reasons,
including
the
fact
no
one
knows
what
causes
it,
side
effects
anti-microbial
treatment,
and
how
various
kinds
bacteria
interact
with
another.
As
result,
novel
therapeutic
approaches
PD
treatment
must
developed.
Additionally,
supplementary
antibacterial
regimens,
local
systemic
medication
administration
chemical
agents,
are
necessary
deep
pockets
assist
mechanical
debridement
tooth
surfaces.
our
knowledge
periodontal
disease
drug
delivery
systems
(DDSs)
grows,
new
targeted
like
extracellular
vesicles,
lipid-based
nanoparticles
(NPs),
metallic
NPs,
polymer
NPs
have
been
These
aim
improve
targeting
precision
treatments
while
reducing
antibiotics.
Nanozymes,
photodermal
therapy,
traditional
therapies
all
reviewed
in
this
research.
Medicinal
herbs,
antibiotics,
photothermal
nanozymes,
conventional
examined
After
that,
we
key
features
many
innovative
DDSs
they
worked
therapy.
Finally,
discussed
advantages
disadvantages
these
DDSs.
International Dental Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 1, 2024
This
study
aimed
to
explore
the
therapeutic
potential
of
medicinal
herbs
for
chronic
periodontitis
by
examining
molecular
interactions
between
specific
herbal
compounds
and
heme-binding
protein
Porphyromonas
gingivalis,
a
key
pathogen
involved
in
disease.
