Alzheimer’s Disease, Obesity, and Type 2 Diabetes: Focus on Common Neuroglial Dysfunctions (Critical Review and New Data on Human Brain and Models) DOI Creative Commons
A. Tolédano, Arantxa Rodríguez‐Casado,

María‐Isabel Álvarez

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 1101 - 1101

Published: Oct. 30, 2024

Obesity, type 2 diabetes (T2D), and Alzheimer's disease (AD) are pathologies that affect millions of people worldwide. They have no effective therapy difficult to prevent control when they develop. It has been known for many years these diseases pathogenic aspects in common. We highlight this review neuroglial cells (astroglia, oligodendroglia, microglia) play a vital role the origin, clinical-pathological development, course brain neurodegeneration. Moreover, we include new results T2D-AD mouse model (APP+PS1 mice on high-calorie diet) investigating.

Language: Английский

Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence DOI Creative Commons

Enzo Pereira de Lima,

Lucas Fornari Laurindo,

Vitor Cavallari Strozze Catharin

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 124 - 124

Published: Feb. 13, 2025

Neurodegenerative diseases comprise a group of chronic, usually age-related, disorders characterized by progressive neuronal loss, deformation structure, or loss function, leading to substantially reduced quality life. They remain significant focus scientific and clinical interest due their increasing medical social importance. Most neurodegenerative present intracellular protein aggregation extracellular deposition (plaques), such as α-synuclein in Parkinson's disease amyloid beta (Aβ)/tau aggregates Alzheimer's. Conventional treatments for conditions incur high costs are related the development several adverse effects. In addition, many patients irresponsive them. For these reasons, there is growing tendency find new therapeutic approaches help patients. This review intends investigate some phytocompounds' effects on diseases. These generally increased oxidative stress inflammation, so phytocompounds can prevent treat To achieve our aim provide critical assessment current literature about phytochemicals targeting neurodegeneration, we reviewed reputable databases, including PubMed, EMBASE, COCHRANE, seeking trials that utilized against conditions. A few investigated humans, after screening, 13 were ultimately included following PRISMA guidelines. compounds include polyphenols (flavonoids luteolin quercetin, phenolic acids rosmarinic acid, ferulic caffeic other like resveratrol), alkaloids (such berberine, huperzine A, caffeine), terpenoids ginkgolides limonene). The gathered evidence underscores caffeine, ginkgolides, primarily anti-inflammatory, antioxidant, neuroprotective, counteracting neuroinflammation, oxidation, synaptic dysfunctions, which crucial aspects intervention various conditions, Alzheimer's dementias, depression, neuropsychiatric disorders. summary, they show use improvements cognition, memory, disinhibition, irritability/lability, aberrant behavior, hallucinations, mood

Language: Английский

Citations

5
Energy Metabolism and Brain Aging: Strategies to Delay Neuronal Degeneration DOI Creative Commons

Donghui Na,

Z. Zhang,

Meng Meng

et al.

Cellular and Molecular Neurobiology, Journal Year: 2025, Volume and Issue: 45(1)

Published: April 21, 2025

Abstract Aging is characterized by a gradual decline in physiological functions, with brain aging being major risk factor for numerous neurodegenerative diseases. Given the brain’s high energy demands, maintaining an adequate ATP supply crucial its proper function. However, advancing age, mitochondria dysfunction and deteriorating metabolism lead to reduced overall production impaired mitochondrial quality control (MQC). As result, promoting healthy has become key focus contemporary research. This review examines relationship between aging, highlighting connection MQC metabolism, proposes strategies delay targeting metabolism.

Language: Английский

Citations

0
Design and synthesis of novel carbamate derivatives as cholinesterase inhibitors for the treatment of Alzheimer's disease: bioassay and molecular dynamics DOI

Kimia Mohammadi,

Vahid Eskandarpour, Hamid Nadri

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142451 - 142451

Published: April 1, 2025

Language: Английский

Citations

0
Alzheimer’s Disease, Obesity, and Type 2 Diabetes: Focus on Common Neuroglial Dysfunctions (Critical Review and New Data on Human Brain and Models) DOI Creative Commons
A. Tolédano, Arantxa Rodríguez‐Casado,

María‐Isabel Álvarez

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 1101 - 1101

Published: Oct. 30, 2024

Obesity, type 2 diabetes (T2D), and Alzheimer's disease (AD) are pathologies that affect millions of people worldwide. They have no effective therapy difficult to prevent control when they develop. It has been known for many years these diseases pathogenic aspects in common. We highlight this review neuroglial cells (astroglia, oligodendroglia, microglia) play a vital role the origin, clinical-pathological development, course brain neurodegeneration. Moreover, we include new results T2D-AD mouse model (APP+PS1 mice on high-calorie diet) investigating.

Language: Английский

Citations

3