Role of Non-Coding RNAs in Hepatocellular Carcinoma Progression: From Classic to Novel Clinicopathogenetic Implications DOI Open Access
Mario Romeo, Marcello Dallio, Flavia Scognamiglio

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(21), P. 5178 - 5178

Published: Oct. 27, 2023

Hepatocellular carcinoma (HCC) is a predominant malignancy with increasing incidences and mortalities worldwide. In Western countries, the progressive affirmation of Non-alcoholic Fatty Liver Disease (NAFLD) as main chronic liver disorder in which HCC occurrence appreciable even non-cirrhotic stages, constitutes real health emergency. light this, further comprehension molecular pathways supporting onset progression represents current research challenge to achieve more tailored prognostic models appropriate therapeutic approaches. RNA non-coding transcripts (ncRNAs) are involved regulation several cancer-related processes, including HCC. When dysregulated, these molecules, conventionally classified "small ncRNAs" (sncRNAs) "long (lncRNAs) have been reported markedly influence HCC-related mechanisms. this review, we describe dysregulated ncRNAs relative progression, analyzing their implications certain etiologically related contexts, applicability clinical practice novel diagnostic, prognostic, tools. Finally, given growing evidence immune system response, oxidative stress-regulated mechanisms, gut microbiota composition relevant emerging elements mutually influencing liver-cancerogenesis investigate relationship triad, shedding on pathogenetic frontiers progression.

Language: Английский

Wnt/β-Catenin signaling pathway in hepatocellular carcinoma: pathogenic role and therapeutic target DOI Creative Commons

Zekun Zhao,

Tenglu Cui,

Fengxian Wei

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: April 2, 2024

Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor and one of leading causes cancer-related deaths worldwide. The Wnt/β-Catenin signaling pathway a highly conserved involved in several biological processes, including improper regulation that leads to tumorigenesis progression cancer. New studies have found abnormal activation major cause HCC tumorigenesis, progression, resistance therapy. perspectives approaches treating will arise from understanding this pathway. This article offers thorough analysis pathway’s function its therapeutic implications HCC.

Language: Английский

Citations

11
Role of Non-Coding RNAs in Hepatocellular Carcinoma Progression: From Classic to Novel Clinicopathogenetic Implications DOI Open Access
Mario Romeo, Marcello Dallio, Flavia Scognamiglio

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(21), P. 5178 - 5178

Published: Oct. 27, 2023

Hepatocellular carcinoma (HCC) is a predominant malignancy with increasing incidences and mortalities worldwide. In Western countries, the progressive affirmation of Non-alcoholic Fatty Liver Disease (NAFLD) as main chronic liver disorder in which HCC occurrence appreciable even non-cirrhotic stages, constitutes real health emergency. light this, further comprehension molecular pathways supporting onset progression represents current research challenge to achieve more tailored prognostic models appropriate therapeutic approaches. RNA non-coding transcripts (ncRNAs) are involved regulation several cancer-related processes, including HCC. When dysregulated, these molecules, conventionally classified "small ncRNAs" (sncRNAs) "long (lncRNAs) have been reported markedly influence HCC-related mechanisms. this review, we describe dysregulated ncRNAs relative progression, analyzing their implications certain etiologically related contexts, applicability clinical practice novel diagnostic, prognostic, tools. Finally, given growing evidence immune system response, oxidative stress-regulated mechanisms, gut microbiota composition relevant emerging elements mutually influencing liver-cancerogenesis investigate relationship triad, shedding on pathogenetic frontiers progression.

Language: Английский

Citations

12