Advances in Gut Microbiota-Targeted Therapeutics for Metabolic Syndrome

Microorganisms, Journal Year: 2024, Volume and Issue: 12(5), P. 851 - 851

Published: April 24, 2024

Previous investigations have illuminated the significant association between gut microbiome and a broad spectrum of health conditions, including obesity, diabetes, cardiovascular diseases, psychiatric disorders. Evidence from certain studies suggests that dysbiosis microbiota may play role in etiology obesity diabetes. Moreover, it is acknowledged dietary habits, pharmacological interventions, psychological stress, other exogenous factors can substantially influence microbial composition. For instance, diet rich fiber has been demonstrated to increase population beneficial bacteria, whereas consumption antibiotics reduce these advantageous communities. In light established correlation various pathologies, strategically altering profile represents an emerging therapeutic approach. This be accomplished through administration probiotics or prebiotics, which aim refine and, consequently, mitigate manifestations associated diseases. The present manuscript evaluates recent literature on relationship metabolic syndrome published over past three years anticipates future directions this evolving field.

Language: Английский

Association of Dietary Fiber and Measures of Physical Fitness with High-Sensitivity C-Reactive Protein

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 888 - 888

Published: March 19, 2024

Dietary fiber intake and physical fitness are independently associated with high-sensitivity C-reactive protein (hs-CRP) levels. Nevertheless, the association between dietary intake, measures of fitness, hs-CRP levels has not yet been fully evaluated. We investigated influence a combination including hand grip strength, resistance training, metabolic equivalents tasks, on Data collected from Korea National Health Nutrition Examination Survey (KNHANES) spanning 2015 to 2018 were used in this study. A total 16,934 participants (7434 men 9500 women aged ≥19 years) included After adjusting for confounding factors (age, education, income, marital status, smoking drinking habits, energy aerobic activity), we employed multivariable logistic model examine Among women, odds high lower those highest superior strength compared lowest weaker (odds ratio [OR] = 0.40, 95% confidence interval [CI] 0.24-0.68). The who participated exercise at least three times per week had reduced did engage both (OR 0.53, CI 0.32-0.89; OR 0.19-0.84, respectively). Our findings indicate that elevated

Language: Английский

Dietary calcium intake in relation to metabolic syndrome in adults: A systematic review and dose–response meta‐analysis of epidemiological studies with GRADE assessment

Obesity Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Summary Numerous studies have examined the relationship of calcium intake and metabolic syndrome (MetS) in adults previous decades; but results were inconsistent across different societies. This systematic review dose–response meta‐analysis assessed relation between consumption MetS adults. We did a search all articles published up to July 2023 Scopus, PubMed/Medline, ISI Web Science electronic databases, Google Scholar. Observational investigated association dietary (Ca) eligible be included. For computing estimates, random effects model was applied. Combining 24 effect size from 17 investigations (15 cross‐sectional two cohort studies) with 74,720 participants 18,200 cases showed that highest versus lowest level Ca related 23% significant decreased odds (OR = 0.77; 95% CI: 0.66, 0.89). Linear analysis estimates 12 each 100 mg/day increment associated 3% marginally 0.97; 95%CI: 0.93, 1.01). In nonlinear 67,896 participants, found (P nonlinearity <0.001); such 500 maximum decrease MetS. According this meta‐analysis, likelihood significantly lower higher intake. Further large‐scale prospective are needed obtain stronger more accurate results.

Language: Английский