International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6341 - 6341
Published: June 7, 2024
Olive
oil
phenols
are
recognized
as
molecules
with
numerous
positive
health
effects,
many
of
which
rely
on
their
antioxidative
activity,
i.e.,
the
ability
to
transfer
hydrogen
radicals.
Proton-coupled
electron
reactions
and
tunneling
ubiquitous
in
biological
systems.
Reactions
olive
phenols,
hydroxytyrosol,
tyrosol,
oleuropein,
oleacein,
oleocanthal,
homovanillyl
alcohol,
vanillin,
a
few
phenolic
acids
DPPH•
(2,2-diphenyl-1-picrylhydrazyl)
radical
1,4-dioxane:water
=
95:5
or
99:1
v/v
solvent
mixture
were
studied
through
an
experimental
kinetic
analysis
computational
chemistry
calculations.
The
highest
rate
constants
corresponding
activity
obtained
for
ortho-diphenols
oleacein.
experimentally
determined
isotope
effects
(KIEs)
caffeic
acid
16.0,
15.4,
16.7,
respectively.
Based
these
KIEs,
thermodynamic
activation
parameters,
intrinsic
bond
orbital
(IBO)
along
IRC
path
calculations,
we
propose
proton-coupled
mechanism.
average
local
ionization
energy
donor
Fukui
function
compounds
show
that
most
reactive
electron-donating
sites
associated
π
electrons
above
below
aromatic
ring,
support
IBO
proposed
PCET
reaction
Large
KIEs
isotopic
values
Arrhenius
pre-exponential
factor
AH/AD
0.6,
1.3,
0.3,
respectively,
reveal
involvement
process.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(2), P. 275 - 275
Published: Jan. 13, 2025
Type
2
diabetes
mellitus
(T2DM),
a
serious
metabolic
disorder,
is
worldwide
health
problem
due
to
the
alarming
rise
in
prevalence
and
elevated
morbidity
mortality.
Chronic
hyperglycemia,
insulin
resistance,
ineffective
effect
secretion
are
hallmarks
of
T2DM,
leading
many
secondary
complications.
These
include,
particular,
cardiovascular
disorders,
diabetic
neuropathy,
nephropathy
retinopathy,
foot,
osteoporosis,
liver
damage,
susceptibility
infections
some
cancers.
Polyphenols
such
as
flavonoids,
phenolic
acids,
stilbenes,
tannins,
lignans
constitute
an
extensive
heterogeneous
group
phytochemicals
fresh
fruits,
vegetables
their
products.
Various
vitro
studies,
animal
model
studies
available
clinical
trials
revealed
that
flavonoids
(e.g.,
quercetin,
kaempferol,
rutin,
epicatechin,
genistein,
daidzein,
anthocyanins),
acids
chlorogenic,
caffeic,
ellagic,
gallic
curcumin),
stilbenes
resveratrol),
tannins
procyanidin
B2,
seaweed
phlorotannins),
pinoresinol)
have
ability
lower
enhance
sensitivity
improve
secretion,
scavenge
reactive
oxygen
species,
reduce
chronic
inflammation,
modulate
gut
microbiota,
alleviate
complications
T2DM.
The
interaction
between
polyphenols
conventional
antidiabetic
drugs
offers
promising
strategy
management
treatment
especially
advanced
disease
stages.
Synergistic
effects
with
been
documented,
but
also
antagonistic
interactions
may
impair
drug
efficacy.
Therefore,
additional
research
required
clarify
mutual
order
use
knowledge
applications.
Nevertheless,
dietary
can
be
successfully
applied
part
supportive
for
they
both
obvious
symptoms
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(3), P. 299 - 299
Published: Feb. 28, 2025
The
biodiversity
of
the
Amazon
rainforest
includes
little-known
cocoa
species,
which
are
essential
resources
for
local
communities.
This
study
evaluated
bioactive
compounds
and
antioxidant
antimicrobial
activity
seeds
mucilage
four
non-traditional
species
(Theobroma
subincanum,
T.
speciosum,
bicolor
Herrania
nitida).
Physico-chemical
properties,
minerals,
vitamin
C,
organic
acids,
phenolics,
carotenoids
were
analysed
by
spectrophotometric
chromatographic
techniques.
was
measured
ABTS
DPPH,
along
with
against
Escherichia
coli,
Staphylococcus
aureus,
Pseudomonas
aeruginosa,
Streptococcus
mutans,
as
well
Candida
albicans
tropicalis.
subincanum
scored
high
in
titratable
acidity,
magnesium,
sodium,
syringic
acid,
chlorogenic
caffeic
rutin,
quercetin.
In
contrast,
calcium,
m-coumaric
ferulic
kaempferol,
quercetin
glycoside,
mutans.
speciosum
excelled
malic
tartaric
naringenin,
capacity.
lutein
aureus
albicans,
iron,
potassium,
citric
gallic
acid
4-hydroxybenzoic
zeaxanthin,
β-carotene,
capacity
ABTS.
H.
nitida
has
a
soluble
solids
content.
These
results
highlight
potential
these
sustainable
sources
functional
nutraceuticals.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2849 - 2849
Published: March 1, 2024
Aflatoxins
are
harmful
natural
contaminants
found
in
foods
and
known
to
be
hepatotoxic.
However,
recent
studies
have
linked
chronic
consumption
of
aflatoxins
nephrotoxicity
both
animals
humans.
Here,
we
conducted
a
systematic
review
active
compounds,
crude
extracts,
herbal
formulations,
probiotics
against
aflatoxin-induced
renal
dysfunction,
highlighting
their
mechanisms
action
vitro
vivo
studies.
The
products
dietary
supplements
discussed
this
study
alleviated
oxidative
stress,
inflammation,
tissue
damage,
markers
function,
mostly
animal
models.
Therefore,
the
information
provided
may
improve
management
kidney
disease
associated
with
aflatoxin
exposure
potentially
aid
feed
supplementation.
future
research
is
warranted
translate
outcomes
into
clinical
use
patients.
Archiv der Pharmazie,
Journal Year:
2024,
Volume and Issue:
357(10)
Published: July 15, 2024
Abstract
Cardiovascular
diseases
(CVDs)
contribute
to
major
public
health
issues.
Some
studies
have
found
that
caffeic
acid
(CA)
and
phenethyl
ester
(CAPE)
may
effectively
prevent
or
treat
CVDs.
However,
there
is
a
need
sum
up
our
current
understanding
of
the
possible
beneficial
detrimental
effects
CA
CAPE
on
CVDs
related
mechanisms.
Therefore,
this
study
aimed
summarize
data
topic.
A
methodical
search
was
carried
out
key
databases,
including
Pubmed,
Google
Scholar,
Scopus,
Web
Science,
from
beginning
June
2024.
Studies
were
then
assessed
for
eligibility
based
inclusion
exclusion
criteria.
Treatment
with
significantly
positively
affected
cardiovascular
in
various
aspects,
atherosclerotic
diseases,
myocardial
infarction,
hypertension,
cardiac
arrhythmias,
hypercoagulation
state.
Several
mechanisms
proposed
mediate
these
effects,
transcription
factors
signaling
pathways
associated
antioxidant,
cytostatic,
anti‐inflammatory
processes.
several
via
multiple
during
prevention
treatment
promising
only
reported
through
vitro
animal
studies,
which
reinforces
further
evaluation
human
clinical
investigations.
World Journal of Clinical Cases,
Journal Year:
2023,
Volume and Issue:
11(25), P. 5840 - 5856
Published: Aug. 31, 2023
Insulin,
a
small
protein
with
51
amino
acids
synthesized
by
pancreatic
β-cells,
is
crucial
to
sustain
glucose
homeostasis
at
biochemical
and
molecular
levels.
Numerous
metabolic
dysfunctions
are
related
insulin-mediated
altered
homeostasis.
One
of
the
significant
pathophysiological
conditions
linked
insulin
associated
disorder
diabetes
mellitus
(DM)
(type
1,
type
2,
gestational).
Insulin
resistance
(IR)
one
major
underlying
causes
disorders
despite
its
association
several
physiological
conditions.
Metabolic
syndrome
(MS)
another
condition
that
IR,
hypertension,
obesity.
Further,
other
disorders/diseases
malfunctioning,
which
include
polycystic
ovary
syndrome,
neuronal
disorders,
cancer.
Insulinomas
an
uncommon
β-cell-derived
neuroendocrine
tumor
makes
up
2%
all
neoplasms.
Literature
revealed
different
events,
signaling
pathways,
microRNAs,
microbiota
act
as
connecting
links
between
pathophysiology
such
DM,
insuloma,
neurological
disorder,
MS,
In
this
review,
we
focus
on
insulin-related
mechanisms
pathophysiology.
