Ancestral SARS-CoV-2 immune imprinting persists on RBD but not NTD after sequential Omicron infections DOI Creative Commons
Zuowei Wang, Ling Li,

Ruiping Du

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 2, 2024

Whether Omicron exposures could overcome ancestral SARS-CoV-2 immune imprinting remains controversial. Here we analyzed B cell responses evoked by sequential infections in vaccinated and unvaccinated individuals. Plasma neutralizing antibody titers against variants indicate that is not consistently induced inactivated or recombinant protein vaccines. However, once induced, countered successive challenges. We compared binding specificities, capacities, developing origins targeting epitopes of monoclonal antibodies from individuals with without imprinting. Although receptor-binding domain (RBD) N-terminal (NTD) spike are both primary targets for antibodies, only shapes to RBD impeding the production Omicron-specific while facilitating development broadly antibodies. propose can be either neglected NTD-based vaccines induce variant-specific leveraged RBD-based

Language: Английский

Study on SARS-CoV-2 infection in middle-aged and elderly population infected with hepatitis virus: a cohort study in a rural area of northeast China DOI Creative Commons
Yuchen Pan, Zhifang Jia, Xinyi Yu

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19021 - e19021

Published: Feb. 21, 2025

Background To investigate the symptoms, level of antibody, progression liver disease after SARS-CoV-2 infection in middle-aged and elderly population infected with hepatitis virus. Methods The study was based on a cohort high-risk cancer participants recruited April 2023. Blood sample were collected information obtained through questionnaires. Data reinfection by follow-up until July 31, SARS-CoV-2-specific neutralizing antibody IgG measured. Results A total 599 virus included mean age 61.3 ± 7.4 years. rate 94.7%. Among infected, 132 asymptomatic, 435 symptomatic, no severe cases occurred. Four months infection, difference function aMAP score between uninfected. had higher seropositivity rates both antibodies than uninfected (neutralizing antibody: uninfected: 93.7%, infected: 99.6%; IgG: 59.4%, 98.9%). levels symptomatic those asymptomatic 0.75 AU/mL, asymptomatic: 15.46 symptomatic: 24.76 AU/mL; 15.10 263.84 291.83 AU/mL). By 2023, incidence 17.5%. Conclusions Although high, Omicron may not aggravate hepatitis. showed high positivity IgG. Monitoring mutations targeted prevention care strategies is crucial for vulnerable populations.

Language: Английский

Citations

0
Genomic surveillance of SARS-CoV-2 variants in Guangzhou, China, from April 2023 to March 2024 DOI Creative Commons

Zhuoyun Li,

Liya Li,

Yuyi Min

et al.

Infection Genetics and Evolution, Journal Year: 2025, Volume and Issue: unknown, P. 105747 - 105747

Published: April 1, 2025

After the relaxation of stringent control measures, nationwide large-scale SARS-CoV-2 surveillance was gradually phased out post-2023, transitioning to focused monitoring Influenza-like Illness (ILI) through sentinel hospitals and laboratory networks. Nationally, respiratory pathogens performed via random sampling, resulting in a lack microbial results Guangzhou China. A crucial area scientific inquiry is whether current cases are attributable emergence novel variant. Throat swab samples were obtained from 1478 outpatients 337 hospitalized patients with fever (temperature ≥ 38 °C) cough or sore throat detect SARS-CoV-2. The positive subjected viral whole-genome sequencing phylogenetic analysis. Respiratory pathogen multiplex PCR tests on stratified samples. detected 517 (28.48 %) patients. There higher rates infection among women, older those who hospitalized. total 299 high-quality sequences obtained, including 12 clades 71 pango lineages. advantageous evolved over three peak periods infection, BA.5 (April 2023) XBB (June July then JN.1 (February 2024). 590 distinct amino acid mutations identified across sequences. highest prevalence observed for spike protein mutations, more than 50 % epidemic peaks detected. Epidemiological profiles interactions between other exhibit considerable variation different seasons, tendency toward suppression within each. Surveillance by Eighth People's Hospital provides snapshot Guangzhou, which consistent national offers important data understanding spread southern

Language: Английский

Citations

0
1 μL, 40min: Multimodal COVID-19 antibody protection evaluation with tip optofluidic immunoassay DOI Creative Commons
Xiaotian Tan, Yujuan Chai, Ruihan Li

et al.

hLife, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Ancestral SARS-CoV-2 immune imprinting persists on RBD but not NTD after sequential Omicron infections DOI Creative Commons
Zuowei Wang, Ling Li,

Ruiping Du

et al.

iScience, Journal Year: 2024, Volume and Issue: 28(1), P. 111557 - 111557

Published: Dec. 9, 2024

Language: Английский

Citations

2
Ancestral SARS-CoV-2 immune imprinting persists on RBD but not NTD after sequential Omicron infections DOI Creative Commons
Zuowei Wang, Ling Li,

Ruiping Du

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 2, 2024

Whether Omicron exposures could overcome ancestral SARS-CoV-2 immune imprinting remains controversial. Here we analyzed B cell responses evoked by sequential infections in vaccinated and unvaccinated individuals. Plasma neutralizing antibody titers against variants indicate that is not consistently induced inactivated or recombinant protein vaccines. However, once induced, countered successive challenges. We compared binding specificities, capacities, developing origins targeting epitopes of monoclonal antibodies from individuals with without imprinting. Although receptor-binding domain (RBD) N-terminal (NTD) spike are both primary targets for antibodies, only shapes to RBD impeding the production Omicron-specific while facilitating development broadly antibodies. propose can be either neglected NTD-based vaccines induce variant-specific leveraged RBD-based

Language: Английский

Citations

1