Liver pathology in COVID-19

Russian Journal of Archive of Pathology, Journal Year: 2025, Volume and Issue: 87(1), P. 53 - 53

Published: Feb. 12, 2025

The literature review presents an analysis of the pathogenesis and pathological anatomy liver damage in COVID-19. Liver with steatosis, vascular disorders, mild portal lobular inflammatory infiltration, cholestasis clinically — failure is observed majority patients Chronic diseases infection SARS-CoV-2 tend to decompensate, which significantly worsens prognosis disease. Pathogenesis COVID19 unclear. There was no convincing evidence for hypothesis cytotoxicity hepatocytes or cholangiocytes by SARS-CoV-2. Similar morphological changes described different authors suggest their nonspecific nature multifactorial related hypoxia, cytokin storm, systemic response syndrome, sepsis shock, Covid-associated angio- coagulopathy, as well drug-induced hepatotoxicity. Further research needed clarify pathology

Language: Английский

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Altered liver hemodynamics in patients with COVID-19: a cross sectional study

Journal of Ultrasound, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский

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The Silent Syndrome of Long COVID and Gaps in Scientific Knowledge: A Narrative Review

Viruses, Journal Year: 2024, Volume and Issue: 16(8), P. 1256 - 1256

Published: Aug. 5, 2024

COVID-19 is still a major public health concern, mainly due to the persistence of symptoms or appearance new symptoms. To date, more than 200 long COVID (LC) have been described. The present review describes and maps its relevant clinical characteristics, pathophysiology, epidemiology, genetic nongenetic risk factors. Given currently available evidence on LC, we demonstrate that there are gaps controversies in diagnosis, detection prognostic predictive factors, as well role viral strain vaccination.

Language: Английский

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Liver abnormalities following SARS-CoV-2 infection in children 1 to 10 years of age

Family Medicine and Community Health, Journal Year: 2024, Volume and Issue: 12(1), P. e002655 - e002655

Published: Jan. 1, 2024

Beginning in October 2021 the USA and elsewhere, cases of severe paediatric hepatitis unknown aetiology were identified young children. While adenovirus adenovirus-associated virus have emerged as leading aetiological suspects, we attempted to investigate a potential role for SARS-CoV-2 development subsequent liver abnormalities. We conducted study using retrospective cohorts deidentified, aggregated data from electronic health records over 100 million patients contributed by US healthcare organisations. Compared with propensity score matched children other respiratory infections, aged 1-10 years COVID-19 had higher risk elevated transaminases (HR (95% CI) 2.16 (1.74 2.69)) or total bilirubin 3.02 (1.91 4.78)), new diagnoses diseases 1.67 (1.21 2.30)) 1 6 months after infection. Patients pre-existing abnormalities, abnormalities surrounding acute infection, younger age (1-4 years) illness requiring hospitalisation all similarly risk. Children who developed following more conditions than those infections. These results indicate that may prime patient infections non-infectious diseases. rare (~1 1000), is function diagnosis liver.

Language: Английский

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COVID-19 and the Liver: A Complex and Evolving Picture

Hepatic Medicine Evidence and Research, Journal Year: 2023, Volume and Issue: Volume 15, P. 209 - 220

Published: Nov. 1, 2023

Although the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily attacks system, other organs, such as liver, are also affected. In this overview, effects of SARS-CoV-2 infection on liver in both healthy people and those with pre-existing disease documented; relationship between 19 (COVID-19) vaccination injury is examined; mechanism SARS-CoV-2-associated explored; long-term consequences COVID-19 delineated, without disease.

Language: Английский

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COVID-19, Possible Hepatic Pathways and Alcohol Abuse—What Do We Know up to 2023?

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2212 - 2212

Published: Feb. 12, 2024

The pandemic period due to coronavirus disease 2019 (COVID-19) revolutionized all possible areas of global health. Significant consequences were also related diverse extrapulmonary manifestations this pathology. liver was found be a relatively common organ, beyond the respiratory tract, affected by severe acute syndrome coronavirus-2 (SARS-CoV-2). Multiple studies revealed essential role chronic (CLD) in general outcome infection. Present concerns field are direct hepatic caused COVID-19 and pre-existing disorders as risk factors for course Which mechanism has key phenomenon—previously existing disorder or failure SARS-CoV-2—is still not fully clarified. Alcoholic (ALD) constitutes another elucidated context Should toxic effects ethanol already developed cirrhosis its perceived causative triggering factor impairment patients? In face these discrepancies, we decided summarize whole picture infection, paying special attention ALD focusing on pathological pathways COVID-19, toxicity cirrhosis.

Language: Английский

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Association between ursodeoxycholic acid use and COVID-19 in individuals with chronic liver disease: a nationwide case-control study in South Korea

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: Aug. 27, 2024

Conflicting evidence exists regarding the effects of ursodeoxycholic acid (UDCA) on coronavirus disease 2019 (COVID-19). This study investigates association between UDCA administration and COVID-19 infection its related outcomes in individuals with chronic liver (CLD). A customized research database (n = 3,485,376) was created by integrating data from National Health Insurance Service (NHIS) Korea Disease Control Prevention Agency's databases. The focused patients diagnosed 2021, using NHIS 365 days before diagnosis. To create comparable groups without COVID-19, we used propensity score matching. primary endpoint first confirmed positive result for severe acute respiratory syndrome coronavirus-2. In addition, identified COVID-19-related outcomes. Subgroup analysis were conducted based dose exposure. Data 74,074 CLD analyzed. participants' average age 57.5 years, 52.1% (19,277) those each group male. Those prior exposure had a significantly lower risk (adjusted OR: 0.80, 95% CI [0.76–0.85]) compared to non-UDCA group. Additionally, 0.67, [0.46–0.98]). analyses indicated that there decrease increasing dose. Our large observational highlights potential use readily available as an adjunctive therapy CLD.

Language: Английский

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Effects of COVID-19 on the Liver and Mortality in Patients with SARS-CoV-2 Pneumonia Caused by Delta and Non-Delta Variants: An Analysis in a Single Centre

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 17(1), P. 3 - 3

Published: Dec. 19, 2023

The aim of this study was to ascertain patient characteristics, outcomes, and liver injuries in patients infected with different SARS-CoV-2 variants. Data from consecutive adult severe/critical COVID-19 admitted our hospital during the peak month Delta wave were compared ancestral, Alpha, Omicron waves. dataset 551 hospitalized similar Delta/non-Delta At admission discharge, median aminotransferase levels normal or slightly increased. During (172 vs. 379 non-Delta patients), more died (OR 1.69, 95%CI 1.09–2.56) had injury at discharge (alanine aminotransferase, ALT ≥ 2 ULN) 1.97, 1.08–3.54). In-hospital mortality associated age, lung injury, intensive care unit admission, number cardiovascular comorbidities, diabetes, chronic kidney disease, all inflammatory biomarkers. Serious (ALT 5 × significantly in-hospital = 7.9, 2–28.9). drug-induced (DILI) found treated remdesivir, ULN 2.62, 1.22–5.75). Treatment dexamethasone, immunomodulators showed improved survival, OR 0.50 (95%CI 0.33–0.77). Regardless variant treatment options, less than 2% displayed serious which not be a death predictor multivariable analysis.

Language: Английский

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Liver abnormalities following SARS-CoV-2 infection in children under 10 years of age

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 23, 2023

ABSTRACT Objective Beginning in October 2021 the US and elsewhere, cases of severe pediatric hepatitis unknown etiology were identified young children. While adenovirus adenovirus-associated virus have emerged as leading etiologic suspects, we attempted to investigate a potential role for SARS-CoV-2 development subsequent liver abnormalities. Design We conducted study utilizing retrospective cohorts de-identified, aggregated data from electronic health records over 100 million patients contributed by care organizations. Results Compared propensity-score-matched children with other respiratory infections, aged 1-10 years COVID-19 had higher risk elevated transaminases (Hazard ratio (HR) (95% Confidence interval (CI)) 2.16 (1.74-2.69)) or total bilirubin (HR (CI) 3.02 (1.91-4.78)), new diagnoses diseases 1.67 (1.21-2.30)) one six months after infection. Patients pre-existing abnormalities, abnormalities surrounding acute infection, younger age (1-4 years), illness requiring hospitalization all similarly risk. Children who developed following more conditions than those infections. Conclusion These results indicate that may prime patient infections non-infectious diseases. rare (∼1 1,000), is function diagnosis liver. What already known on this topic Clusters 2022 coincident increase raised question contribution outbreak, though it was soon determined not primary agent. adds How might affect research, practice policy Despite mild initial disease children, there be longer term consequences COVID-19, such warrants further investigation.

Language: Английский

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A Silent Outbreak of Hepatitis E Virus (HEV) Infection or False-Positive Reaction of Anti-HEV IgM after COVID-19 Vaccination? Epidemiological Investigation of an Outbreak in a Korean Factory Complex in 2022

Gut and Liver, Journal Year: 2023, Volume and Issue: 18(3), P. 531 - 538

Published: Oct. 6, 2023

Background/Aims: To investigate a reported outbreak of presumed hepatitis E virus (HEV) infection in Korean food manufacturing facility and to explore the association between anti-HEV immunoglobulin M (IgM) positivity coronavirus disease 2019 (COVID-19) or vaccination.Methods: Twenty-four cases IgM were among 646 workers at 2022.An epidemiological investigation was conducted, comprising HEV-RNA testing blood environmental samples, analysis group meal records, an confirmed COVID-19 vaccination.Results: All 24 patients asymptomatic, with spread sporadically across facility.HEV RNA not detected serum samples.Four out 340 meals (1.2%) showed significantly higher proportion each intake than non-intake on certain days.Although cumulative rate no difference, positive proportions >2 doses vaccination (83.3% vs 48.7%, p=0.021), within 90 days (45.8% 19.7%, p=0.008), having Moderna vaccine administered as last (75.0%vs 14.5%, p<0.001) those negative group.In four multivariable models, three more vaccinations consistently associated positivity, while specific day also significant factor.Conclusions: This that may occur false-positive result related COVID-vaccination over times use vaccine, although portion true HEV be excluded.(Gut Liver,

Language: Английский

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