Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(6), P. 1213 - 1213
Published: June 7, 2022
Colorectal
cancer
(CRC)
is
a
global
health
problem
responsible
for
10%
of
all
incidences
and
9.4%
deaths
worldwide.
The
number
new
cases
increases
per
annum,
whereas
the
lack
effective
therapies
highlights
need
novel
therapeutic
approaches.
Conventional
treatment
methods,
such
as
surgery,
chemotherapy
radiotherapy,
are
widely
applied
in
oncology
practice.
Their
success
little,
therefore,
search
technologies
ongoing.
Many
efforts
have
focused
recently
on
development
safe
efficient
nanomedicines.
Nanoparticles
among
them.
They
uniquewith
their
properties
nanoscale
hold
potential
to
exploit
intrinsic
metabolic
differences
between
healthy
cells.
This
feature
allows
them
induce
high
levels
toxicity
cells
with
little
damage
surrounding
tissues.
Graphene
oxide
promising
2D
material
found
play
an
important
role
treatments
through
several
strategies:
direct
killing
chemosensitization,
drug
gene
delivery,
phototherapy.
Several
approaches
based
nanoparticles,
particularly
graphene
oxide,
currently
under
research
clinical
trials,
some
already
been
approved.
Here,
we
provide
update
recent
advances
nanomaterials-based
CRC-targeted
therapy,
special
attention
nanomaterials.
We
summarise
epidemiology,
carcinogenesis,
stages
CRCs,
current
its
treatment.
Cancers,
Journal Year:
2021,
Volume and Issue:
13(9), P. 2025 - 2025
Published: April 22, 2021
This
review
article
contains
a
concise
consideration
of
genetic
and
environmental
risk
factors
for
colorectal
cancer.
Known
associated
with
cancer
include
familial
hereditary
lifestyle-related
ecological
factors.
Lifestyle
are
significant
because
the
potential
improving
our
understanding
disease.
Physical
inactivity,
obesity,
smoking
alcohol
consumption
can
also
be
addressed
through
therapeutic
interventions.
We
made
efforts
to
systematize
available
literature
data
on
epidemiology,
diagnosis,
type
nature
symptoms
disease
stages.
Further
study
progress
globally
is
crucial
inform
future
strategies
in
controlling
disease’s
burden
population-based
preventative
initiatives.
Molecules,
Journal Year:
2020,
Volume and Issue:
25(6), P. 1324 - 1324
Published: March 13, 2020
Aloe
vera
has
been
traditionally
used
to
treat
skin
injuries
(burns,
cuts,
insect
bites,
and
eczemas)
digestive
problems
because
its
anti-inflammatory,
antimicrobial,
wound
healing
properties.
Research
on
this
medicinal
plant
aimed
at
validating
traditional
uses
deepening
the
mechanism
of
action,
identifying
compounds
responsible
for
these
activities.
The
most
investigated
active
are
aloe-emodin,
aloin,
aloesin,
emodin,
acemannan.
Likewise,
new
actions
have
compounds.
This
review
provides
an
overview
current
pharmacological
studies
(in
vitro,
in
vivo,
clinical
trials),
written
English
during
last
six
years
(2014–2019).
In
particular,
data
research
shown
that
refer
anti-cancer
protective
activity,
antimicrobial
Most
recent
works
vitro
vivo.
Clinical
trials
conducted
just
with
vera,
but
not
isolated
compounds;
therefore,
it
would
be
interesting
study
effect
relevant
metabolites
different
human
conditions
pathologies.
promising
results
basic
encourage
a
greater
number
test
application
main
compounds,
particularly
bone
protection,
cancer,
diabetes.
Current Drug Targets,
Journal Year:
2020,
Volume and Issue:
22(9), P. 998 - 1009
Published: Nov. 19, 2020
Colorectal
cancer
(CRC)
is
the
third
most
common
and
second
leading
cause
of
related
deaths
in
world
with
an
estimated
number
1.8
million
new
cases
about
881,000
worldwide
2018.
The
epidemiology
CRC
varies
significantly
between
different
regions
as
well
age,
gender
racial
groups.
Multiple
factors
are
involved
this
variation,
including
risk
factor
exposure,
demographic
variations
addition
to
genetic
susceptibility
mutations
their
effect
on
prognosis
treatment
response.
In
mini-review,
we
discuss
recent
epidemiological
trend
incidence
mortality
colorectal
affecting
these
trends.
Autophagy,
Journal Year:
2021,
Volume and Issue:
18(1), P. 86 - 103
Published: April 27, 2021
Macroautophagy/autophagy
is
a
cellular
catabolic
process
that
results
in
lysosome-mediated
recycling
of
organelles
and
protein
aggregates,
as
well
the
destruction
intracellular
pathogens.
Its
role
maintenance
intestinal
epithelium
particular
interest,
several
autophagy-related
genes
have
been
associated
with
disease.
Autophagy
its
regulatory
mechanisms
are
involved
both
homeostasis
repair
intestine,
supporting
barrier
function
response
to
stress
through
tight
junction
regulation
protection
from
cell
death.
Furthermore,
clear
has
emerged
for
autophagy
not
only
secretory
cells
but
also
stem
cells,
where
it
affects
their
metabolism,
proliferative
regenerative
capacity.
Here,
we
review
physiological
context
epithelial
how
genetic
mutations
affecting
contribute
development
Gut,
Journal Year:
2021,
Volume and Issue:
71(10), P. 2011 - 2021
Published: Dec. 22, 2021
Objective
Using
faecal
shotgun
metagenomic
sequencing,
we
identified
the
depletion
of
Lactobacillus
gallinarum
in
patients
with
colorectal
cancer
(CRC).
We
aimed
to
determine
potential
antitumourigenic
role
L.
tumourigenesis.
Design
The
tumor-suppressive
effect
was
assessed
murine
models
CRC.
CRC
cell
lines
and
organoids
derived
from
were
cultured
or
Escherichia
coli
MG1655
culture-supernatant
evaluate
proliferation,
apoptosis
cycle
distribution.
Gut
microbiota
by
16S
ribosomal
DNA
sequencing.
Antitumour
molecule
produced
liquid
chromatography
mass
spectrometry
(LC-MS/MS)
targeted
spectrometry.
Results
significantly
reduced
intestinal
tumour
number
size
compared
E.
phosphate-buffered
saline
both
male
female
tumourigenesis
models.
Faecal
microbial
profiling
revealed
enrichment
probiotics
pathogenic
bacteria
-treated
mice.
Culturing
cells
(5%,
10%
20%)
concentration-dependently
suppressed
proliferation
colony
formation.
promoted
patient-derived
organoids,
but
not
normal
colon
epithelial
cells.
Only
fraction
<3
kDa
LC-MS/MS,
enrichments
indole-3-lactic
acid
(ILA)
gut
ILA
displayed
anti-CRC
growth
vitro
inhibited
vivo
.
Conclusion
protects
against
producing
protective
metabolites
that
can
promote
Frontiers in Immunology,
Journal Year:
2020,
Volume and Issue:
11
Published: June 30, 2020
Gastrointestinal
(GI)
cancers,
especially
gastric
cancer
and
colorectal
(CRC),
represent
a
major
global
health
burden.
A
large
population
of
microorganisms
residing
in
the
GI
tract
regulate
physiological
processes,
such
as
immune
response,
metabolic
balance,
homeostasis.
Accumulating
evidence
has
revealed
alteration
microbial
communities
tumorigenesis.
Experimental
studies
cell
lines
animal
models
showed
functional
roles
molecular
mechanisms
several
bacteria
including
Helicobacter
pylori
well
Fusobacterium
nucleatum,
Escherichia
coli,
Peptostreptococcus
anaerobius,
Bacteroides
fragilis
CRC.
The
transcriptional
factor
NF-κB
plays
crucial
role
host
response
to
infection
through
orchestrating
innate
adaptive
functions.
Moreover,
activity
is
linked
initiation
development
its
induction
chronic
inflammation,
cellular
transformation
proliferation.
Here,
we
provide
an
overview
discussion
modulation
signaling
pathway
by
microbiota,
infectious
bacteria,
tumorigenesis,
with
focus
on
