World Journal of Clinical Oncology, Journal Year: 2024, Volume and Issue: 15(7), P. 786 - 789
Published: July 16, 2024
The review article by Pavlidis
Language: Английский
ANZ Journal of Surgery, Journal Year: 2025, Volume and Issue: unknown
Published: March 24, 2025
ANZ Journal of SurgeryEarly View IMAGES FOR SURGEONS Combination Lenvatinib and pembrolizumab as neoadjuvant treatment for BRAF negative anaplastic thyroid cancer Zhao Jie BMed/MD, MS, MS orcid.org/0000-0002-9766-991X Endocrine Surgery, Fiona Stanley Hospital, Perth, Western Australia, AustraliaSearch more papers by this authorBella Nguyen MBBS, FRACP, Bella FRACP Australia Contribution: Conceptualization, Writing - review & editingSearch authorDean Lisewski BSc (Hons1), MB BS, FRCSI, FRACS, Dean FRACS author First published: 24 March 2025 https://doi.org/10.1111/ans.70104Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare text full-text accessPlease our Terms Conditions Use check box below share version article.I have read accept Wiley Online Library UseShareable LinkUse link a article with your friends colleagues. Learn more.Copy URL Share linkShare onEmailFacebookxLinkedInRedditWechat No abstract is available article. References 1Kishikawa M, Inoue J, Hamamoto H, Kobayashi K, Asakage T, Inazawa J. Augmentation lenvatinib efficacy topical miR-634 ointment in cancer. Biochem. Biophys. Rep. 2021; 26: 101009. 10.1016/j.bbrep.2021.101009 CASPubMedWeb Science®Google Scholar 2Soll D, Bischoff P, Frisch A et al. effectiveness data first-line therapy advanced cancer: retrospective cohort study. BMC Endocr. Disord. 2024; 24: 25. 10.1186/s12902-024-01555-y 3Luongo C, Porcelli Sessa F salvage paucicellular variant case report. Curr. Oncol. 28: 5401–5407. 10.3390/curroncol28060450 PubMedWeb 4Pavlidis ET, Galanis IN, Pavlidis TE. Update on current diagnosis management carcinoma. World Clin. 2023; 14: 570–583. 10.5306/wjco.v14.i12.570 5Bible KC, Kebebew E, Brierley J 2021 American Thyroid Association guidelines Management Patients 31: 337–386. 10.1089/thy.2020.0944 6Dierks Seufert Aumann K an effective option poorly differentiated 1076–1085. 10.1089/thy.2020.0322 7Jannin A, Escande Al Ghuzlan Anaplastic carcinoma: update. Cancers (Basel) 2022; 1061. 10.3390/cancers14041061 8Park Jung HA, Shim JH Multimodal treatments outcomes before after tyrosine kinase inhibitor therapy: real-world experience. Eur. Endocrinol. 184: 837–845. 10.1530/EJE-20-1482 Early ViewOnline Version Record inclusion issue ReferencesRelatedInformation
Language: Английский
Citations
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Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(9), P. 2898 - 2898
Published: April 23, 2025
Anaplastic thyroid carcinoma (ATC) is the rarest and most aggressive form of cancer, marked by a poor prognosis resistance to conventional treatments. Like many malignancies, ATC has complex genetic landscape, with numerous mutations driving tumor initiation, progression, therapeutic resistance. However, recent advances in molecular research have expanded our understanding these alterations, paving way for new targeted treatment strategies. Currently, therapies targeting specific mutations, such as BRAF MEK, show promise, but their effectiveness limited patients harboring mutations. To explore broader possibilities, we conducted comprehensive literature review using PubMed database Google identify studies on key ATC. By leveraging insights, aim highlight potential avenues that could enhance options improve patient outcomes.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 13, 2025
While most thyroid cancer patients have a favorable prognosis, anaplastic carcinoma (ATC) remains particularly aggressive form with median survival time of just five months. Conventional therapies offer limited benefits for this type cancer. Our study aims to identify ATC who might bene t from immunotherapy. uses multiple algorithms by R4.2.0, and gene expression clinical data are collected TCGA, GEO local cohort. In vitro experiments, such as western blot immunofluorescence staining, performed. Using set genes uniquely expressed across various types cancer, we developed machine-learning model distinguish each within the dataset (GSE60542, GSE76039, GSE33630, GSE53157, GSE65144, GSE29265, GSE82208, GSE27155, GSE58545, GSE54958, GSE32662). These allowed us stratify into three distinct groups, exhibiting significantly different responses anti-PD1 therapy determined consensus clustering. Through weighted co-expression network analysis (WGCNA), identified 12 differentially closely associated immunotherapy outcomes. This led creation refined signature predicting ATC's immune responsiveness therapy, which was further validated using cohorts TCGA nine melanoma trials. Among genes, HLF stood out due its strong association hallmarks. revealed that impedes progression down-regulating epithelial-to-mesenchymal transition (EMT) pathway, reducing T cell exhaustion, increasing sensitivity sorafenib, demonstrated through our in-vitro experiments.
Language: Английский
Citations
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Zabajkalʹskij medicinskij vestnik, Journal Year: 2025, Volume and Issue: 1, P. 217 - 228
Published: May 8, 2025
Anaplastic thyroid cancer is a highly aggressive malignant neoplasm characterized by rapid growth and an extremely unfavorable prognosis. The incidence of this tumor 1-2% all cases. Diagnosis type often associated with significant difficulties large morphological diversity cells. article presents clinical case reflecting the in diagnosing anaplastic cancer. role capabilities radiation, cytological, pathological, immunohistochemical molecular genetic research methods for timely diagnosis are discussed. It necessary to remember possibility detecting patients signs malignancy organ not only oncologists, but also therapists, endocrinologists surgeons referral additional examination patients, given prognosis disease.
Language: Английский
Citations
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Journal of Clinical Pathology, Journal Year: 2024, Volume and Issue: unknown, P. jcp - 209060
Published: July 9, 2024
The most recent WHO classification of endocrine and neuroendocrine tumours has brought about significant changes in the diagnosis grading these lesions. For instance, pathologists now have ability to stratify subsets thyroid adrenal neoplasms using various histological features composite risk assessment models. Moreover, novel recommendations on how approach neoplasia involve additional immunohistochemical analyses, recognition implementation key markers is essential for modernising diagnostic capabilities. Additionally, an improved understanding tumour origin led renaming several entities, resulting emergence terminology not yet universally recognised. adjustments nomenclature prognostication may pose a challenge clinical team, care providers might be eager engage dialogue with diagnosing pathologist, as treatment guidelines fully caught up changes. Therefore, it crucial surgical pathologist aware knowledge behind scheme. This review article will delve into prognostic related lesions parathyroid, thyroid, glands gastroenteropancreatic system. author briefly share his personal reflections implementation, drawing from couple years experience new algorithms.
Language: Английский
Citations
3
World Journal of Clinical Oncology, Journal Year: 2024, Volume and Issue: 15(6), P. 684 - 686
Published: June 24, 2024
In this editorial we comment on the article by Pavlidis et al , published in recent issue of World Journal Oncology . We focus contributions management anaplastic thyroid carcinoma, highlighting importance surgery and radiotherapy as first line therapies its introduction new systemic beyond chemotherapy, focused molecular alterations, an essential step diagnosis included clinical guidelines for selection ideal treatment. contrast to other neoplasms, immunotherapy, is still beginning studies pathology with encouraging results. Therefore, multimodal together drugs seems be logical increase survival neoplasm.
Language: Английский
Citations
2
Published: April 4, 2024
The genetic causes of the differentiated, highly treatable and mostly non-fatal papillary thyroid cancer (PTC) are not yet fully known. widely accepted PTC etiology blames altered sequence or/and expression level certain biomarker genes. However, our previous studies found that biomarkers played significantly lower roles than personalized Gene Master Regulators. Our publicly accessible gene data from nodule surrounding normal tissue surgically removed tumor were re-analyzed to determine transcriptomic effects on genomic fabrics responsible for DNA replication, repair transcription. Tumor results compared profiles (BCPAP) anaplastic (8505C) human cell lines. analyses carried out Genomic Fabric Paradigm (GFP) perspective provides most theoretically possible comprehensive characterization transcriptome its alterations in disease. study indicated that, addition regulating numerous genes, changes homeostatic control transcript abundances remodeling networks had major contributions occurrence, resilience proliferation. Therefore, molecular mechanisms inter-coordination should also be considered when designing anti-cancer therapies.
Language: Английский
Citations
1
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: March 29, 2024
Abstract Purpose Anaplastic thyroid cancer (ATC) is rare but one of the most lethal human malignancy. Despite advances in treatments, ATC remained incurable due to a lack effective treatments. cells display resistance against all cytostatics. Adriamycin and taxanes have been used with limited efficacy. There an urgent need for new treatments less toxic substances that will enhance effectiveness current One curcumin derivative, tetrahydrocurcumin (THC), appears several anti-cancer anti-MDR (multidrug resistance) actions. Thus, we aimed compare efficacy THC adriamycin docetaxel, as well evaluate action two drugs cell lines, if any. Methods We MTT test find IC50 values (Adr), docetaxel (Doce) (Cur). The were treated half-IC50 (IC25) doses. IC25 doses also drug combinations. Wound healing assay, spheroid formation soft agar, oxidative stress analysis, flow-cytometrically apoptosis, multidrug activity factor analysis (MAF) MDR1 (P-gp), MRP1/2, BCRP expressions performed both lines. Results was more potent than on migration, formation, anti-oxidant capacity, apoptosis induction at LD50 dose THC-induced MAF suppression found particularly Whereas lead increased MRP1/2 expressions. suppressed these actions dependent manner. Conclusion can modify MDR protein stem properties, which increase doxorubicin treating anaplastic cancer. has potential comparable Curcumin could be considered adjunctive component treatment.
Language: Английский
Citations
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Genes, Journal Year: 2024, Volume and Issue: 15(5), P. 621 - 621
Published: May 14, 2024
The genetic causes of the differentiated, highly treatable, and mostly non-fatal papillary thyroid cancer (PTC) are not yet fully understood. accepted PTC etiology blames altered sequence or/and expression level certain biomarker genes. However, tumor heterogeneity patient’s unique set favoring factors question fit-for-all gene biomarkers. Publicly accessible profiles nodule surrounding normal tissue from a surgically removed were re-analyzed to determine cancer-induced alterations genomic fabrics responsible for major functional pathways. Tumor data compared with those standard anaplastic cell lines. We found that regulated numerous genes associated DNA replication, repair, transcription. Results further indicated changes networking in pathways homeostatic control transcript abundances also had contributions phenotype occurrence. purpose proliferate invade entire gland may explain substantial transcriptomic differences we detected between cells spread homo-cellular cultures (where they need only survive). In conclusion, should include complex molecular mechanisms involved remodeling information processing
Language: Английский
Citations
0
IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: June 14, 2024
The present chapter provides an in-depth review of the prevalence, diagnostic challenges, and management strategies for thyroid nodules, emphasizing integration various modalities to enhance precision guide therapeutic decisions. Thyroid nodules are frequently encountered in clinical settings, with a significant proportion detected incidentally. While most benign, potential malignancy necessitates careful evaluation, primarily through ultrasound-guided fine-needle aspiration (FNA). However, FNA has limitations, including unsatisfactory indeterminate results, which may lead unnecessary interventions. discusses evolution techniques, role ultrasonography, molecular diagnostics, core needle biopsy, alongside traditional FNA. It highlights recent experiences studies that address ambiguities, aiming optimize patient outcomes by reducing surgeries improving accuracy. impact external factors, such as COVID-19 pandemic on nodule is explored. Through comprehensive analysis, seeks provide clinicians updated insights into managing effectively diverse contexts.
Language: Английский
Citations
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