Healthy and unhealthy plant‐based diets in relation to the incidence of colorectal cancer overall and by molecular subtypes DOI Creative Commons
Fenglei Wang, Tomotaka Ugai, Koichiro Haruki

et al.

Clinical and Translational Medicine, Journal Year: 2022, Volume and Issue: 12(8)

Published: Aug. 1, 2022

Abstract Background Plant‐based foods have been recommended for health. However, not all plant are healthy, and little is known about the association between plant‐based diets specific molecular subtypes of colorectal cancer (CRC). We examined associations healthy unhealthy with incidence CRC its subtypes. Methods While 123 773 participants Nurses’ Health Study Professionals Follow‐up had followed up (3 143 158 person‐years), 3077 them developed CRC. Healthy diet indices (hPDI uPDI, respectively) were calculated using repeated food frequency questionnaire data. determined tumoural status microsatellite instability (MSI), CpG island methylator phenotype (CIMP), BRAF KRAS mutations. Results Higher hPDI was associated lower (multivariable hazard ratio [HR] comparing extreme quartiles, 0.86, 95% confidence interval [CI]: 0.77, 0.96; P ‐trend = .04), whereas higher uPDI HR 1.16, CI: 1.04, 1.29; .005). The significantly differed by ( ‐heterogeneity .003) but other tumour markers. ‐wildtype 0.74, 0.57, .004) ‐mutant .22). Conclusions enriched refined grains sugar incidence, rich in whole grains, fruits vegetables CRC, especially

Language: Английский

Changes in lipids composition and metabolism in colorectal cancer: a review DOI Creative Commons
Alicja Pakiet, Jarek Kobiela, Piotr Stepnowski

et al.

Lipids in Health and Disease, Journal Year: 2019, Volume and Issue: 18(1)

Published: Jan. 26, 2019

Altered metabolism of lipids is currently considered a hallmark characteristic many malignancies, including colorectal cancer (CRC). Lipids are large group metabolites that differ in terms their fatty acid composition. This review summarizes recent evidence, documenting alterations the content and composition acids, polar lipids, oxylipins triacylglycerols CRC patients' sera, tumor tissues adipose tissue. Some altered lipid molecules may be potential biomarkers risk, development progression. Owing to significant role cell metabolism, some pathways also constitute specific targets for anti-CRC therapy.

Language: Английский

Citations

261
Metastatic colorectal cancer: mechanisms and emerging therapeutics DOI Creative Commons
Alice E. Shin, Filippo G. Giancotti,

Anil K. Rustgi

et al.

Trends in Pharmacological Sciences, Journal Year: 2023, Volume and Issue: 44(4), P. 222 - 236

Published: Feb. 23, 2023

Language: Английский

Citations

259
Design and Production of Bispecific Antibodies DOI Creative Commons
Qiong Wang, Yiqun Chen, Jaeyoung Park

et al.

Antibodies, Journal Year: 2019, Volume and Issue: 8(3), P. 43 - 43

Published: Aug. 2, 2019

With the current biotherapeutic market dominated by antibody molecules, bispecific antibodies represent a key component of next-generation therapy. Bispecific can target two different antigens at same time, such as simultaneously binding tumor cell receptors and recruiting cytotoxic immune cells. Structural diversity has been fast-growing in field, creating plethora novel scaffolds, which provide great functional variety. Two common formats on are single-chain variable fragment (scFv)-based (no Fc fragment) full-length IgG-like asymmetric antibody. Unlike conventional monoclonal antibodies, production challenges with respect to quantity, quality, stability have hampered their wider clinical application acceptance. In this review, we focus these major types describe recent advances design, production, quality will enable important class biologics reach therapeutic potential.

Language: Английский

Citations

219
Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins DOI Creative Commons

Yaxian Zhou,

Peng Teng,

Nathan T. Montgomery

et al.

ACS Central Science, Journal Year: 2021, Volume and Issue: 7(3), P. 499 - 506

Published: March 4, 2021

Targeted protein degradation (TPD) technology has drawn significant attention from researchers in both academia and industry. It is rapidly evolved as a new therapeutic modality also useful chemical tool selectively depleting various targets. As most efforts focus on cytosolic proteins using PROteolysis TArgeting Chimera (PROTAC), LYsosome (LYTAC) recently emerged promising to deliver extracellular targets lysosome for through the cation-independent mannose-6-phosphate receptor (CI-M6PR). In this study, we exploited potential of asialoglycoprotein (ASGPR), lysosomal targeting specifically expressed liver cells, including membrane proteins. The ligand ASGPR, triantennary N-acetylgalactosamine (tri-GalNAc), was conjugated biotin, antibodies, or fragments antibodies generate class degraders. We demonstrated that could be successfully internalized delivered into cell lines by these This work will add dimension TPD with type specificity.

Language: Английский

Citations

153
Colorectal Cancer: From Risk Factors to Oncogenesis DOI Creative Commons
Vlad Ionescu, Gina Gheorghe, Nicolae Bacalbașa

et al.

Medicina, Journal Year: 2023, Volume and Issue: 59(9), P. 1646 - 1646

Published: Sept. 12, 2023

Colorectal cancer is the second leading cause of cancer-related mortality worldwide. Numerous pathophysiological mechanisms, such as abnormal cell proliferation, differentiation, resistance to apoptosis, invasion structures adjacent colorectal tumor cells, and distant metastasis, are involved in carcinogenesis. These processes initiated by complex interaction a number genetic environmental factors, including sedentary lifestyle, obesity, alcohol consumption, smoking, or gut microbiota. Despite significant progress achieved diagnostic therapeutic management patients with cancer, there has been recently noteworthy increase incidence individuals below age 50 years. Early-onset different frequency oncogenic mutations, higher prevalence mucinous histology, distinct deoxyribonucleic acid (DNA) methylation profile, more distal location, lower survival rates. A improvement prognosis these can be through detection removal modifiable risk along implementation personalized screening strategies for at high this malignancy. Furthermore, gaining comprehension mechanisms which factors contribute process oncogenesis may facilitate discovery novel targets.

Language: Английский

Citations

75
Inorganic nanoparticle-based treatment approaches for colorectal cancer: recent advancements and challenges DOI Creative Commons

Soumya Narayana,

B.H. Jaswanth Gowda, Umme Hani

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 19, 2024

Abstract Colorectal cancer, the third most prevalent cancer globally, contributes significantly to mortality rates, with over 1.9 million reported cases and nearly 935,000 fatalities annually. Surgical resection is a primary approach for localized colorectal tumors, adjunct therapies like chemotherapy, radiotherapy, targeted/immunotherapy considered depending on tumor stage. However, despite preferences targeted immunotherapy post-surgery, chemotherapy remains commonly chosen due its lower cost high cancer-killing efficiency. Yet, faces issues such as resistance severe side effects. Nanotechnology has emerged in therapy by alleviating drawbacks of current treatment approaches. In past few decades, inorganic nanoparticles have shown promise combating offering advantages conventional chemotherapy. Compared organic nanoparticles, exhibit properties photosensitivity, conductivity, magnetic allure, thermal proficiency, allowing them function both drug carriers therapeutic agents. Derived primarily from carbon, silica, metals, metal oxides, they offer superior drug-loading capacity, heightened quantum yield, participation advanced photothermal photodynamic therapies. This review provides brief overview pathophysiology pivotal role therapy, delivery. Additionally, it discusses numerous based recent literature. Graphical abstract

Language: Английский

Citations

25
Chemopreventive and Therapeutic Effects of Edible Berries: A Focus on Colon Cancer Prevention and Treatment DOI Creative Commons
Sadia Afrin, Francesca Giampieri, Massimiliano Gasparrini

et al.

Molecules, Journal Year: 2016, Volume and Issue: 21(2), P. 169 - 169

Published: Jan. 30, 2016

Colon cancer is one of the most prevalent diseases across world. Numerous epidemiological studies indicate that diets rich in fruit, such as berries, provide significant health benefits against several types cancer, including colon cancer. The anticancer activities berries are attributed to their high content phytochemicals and relevant antioxidant properties. In vitro vivo have demonstrated bioactive components exert therapeutic preventive effects by suppression inflammation, oxidative stress, proliferation angiogenesis, through modulation multiple signaling pathways NF-κB, Wnt/β-catenin, PI3K/AKT/PKB/mTOR, ERK/MAPK. Based on exciting outcomes preclinical studies, a few advanced clinical phase. A limited number human shown consumption can prevent colorectal especially patients at risk (familial adenopolyposis or aberrant crypt foci, inflammatory bowel diseases). this review, we aim highlight findings compounds from both animals humans. Thus, review could be useful step towards next phase berry research

Language: Английский

Citations

149
The antitumor activity of naturally occurring chromones: A review DOI

Ya-di Duan,

Yanyan Jiang, Fengxia Guo

et al.

Fitoterapia, Journal Year: 2019, Volume and Issue: 135, P. 114 - 129

Published: April 25, 2019

Language: Английский

Citations

97
Cyclic RGD peptide-modified liposomal drug delivery system for targeted oral apatinib administration: enhanced cellular uptake and improved therapeutic effects DOI Creative Commons
Zhiwang Song, Yunfeng Lin,

Xia Zhang

et al.

International Journal of Nanomedicine, Journal Year: 2017, Volume and Issue: Volume 12, P. 1941 - 1958

Published: March 1, 2017

Apatinib is an oral tyrosine kinase inhibitor, which selectively targets vascular endothelial growth factor receptor 2 and has the potential to treat many tumors therapeutically. Cyclic arginylglycylaspartic acid (cRGD)- polyethylene glycol (PEG)-modified liposomes (cRGD-Lipo-PEG) were constructed act as a targeted delivery system for of apatinib human colonic cancer cell line, HCT116. These cRGD-modified specifically recognized integrin αvβ3 exhibited greater uptake efficiency with respect delivering into HCT116 cells when compared nontargeted (Lipo-PEG), well death tumor apoptosis. The mechanism by cRGD-Lipo-PEG was elucidated further competition assays. To determine anticancer efficacy in vivo, nude mice implanted xenografts treated apatinib-loaded or free intravenously via intragastric administration. active passive targeting led significant treatment ability, better inhibition growth, less toxicity treatments using uncombined apatinib. results presented strongly support case representing cancer.

Language: Английский

Citations

90
EGFR-Based Targeted Therapy for Colorectal Cancer—Promises and Challenges DOI Creative Commons
Balakarthikeyan Janani,

Mayakrishnan Vijayakumar,

K. Priya

et al.

Vaccines, Journal Year: 2022, Volume and Issue: 10(4), P. 499 - 499

Published: March 24, 2022

Colorectal carcinoma (CRC) is the most lethal and common form of cancer in world. It was responsible for almost 881,000 deaths 2018. Approximately 25% cases are diagnosed at advanced stages with metastasis—this poses challenges effective surgical control future tumor-related mortality. There numerous diagnostic methods that can be used to reduce risk colorectal carcinoma. Among these, targeted nanotherapy aims eliminate tumor any metastasis. Active targeting increase effectiveness quantity drugs delivered target site. Antibodies overexpressed receptors on cell surfaces indicators coupled drug-loaded carriers. The major chemotherapeutic delivery include VEGFR, EGFR, FGFR, HER2, TGF. On account its diverse roles cancer, it important EGFR particular better selection, as 25 82% cases. monoclonal immunoglobulins cetuximab/panitumumab thus treat cancer. This review examines carriers contain cetuximab-conjugated therapeutic well their efficacy anticancer activities.

Language: Английский

Citations

63