Cancers,
Journal Year:
2024,
Volume and Issue:
16(21), P. 3703 - 3703
Published: Nov. 1, 2024
Humans
cannot
avoid
plastic
exposure
due
to
its
ubiquitous
presence
in
the
natural
environment.
The
waste
generated
is
poorly
biodegradable
and
exists
form
of
MPs,
which
can
enter
human
body
primarily
through
digestive
tract,
respiratory
or
damaged
skin
accumulate
various
tissues
by
crossing
biological
membrane
barriers.
There
an
increasing
amount
research
on
health
effects
MPs.
Most
literature
reports
focus
impact
plastics
respiratory,
digestive,
reproductive,
hormonal,
nervous,
immune
systems,
as
well
metabolic
MPs
accumulation
leading
epidemics
obesity,
diabetes,
hypertension,
non-alcoholic
fatty
liver
disease.
xenobiotics,
undergo
ADMET
processes
body,
i.e.,
absorption,
distribution,
metabolism,
excretion,
are
not
fully
understood.
Of
particular
concern
carcinogenic
chemicals
added
during
manufacturing
adsorbed
from
environment,
such
chlorinated
paraffins,
phthalates,
phenols,
bisphenols,
be
released
when
absorbed
body.
continuous
increase
NMP
has
accelerated
SARS-CoV-2
pandemic
there
was
a
need
use
single-use
products
daily
life.
Therefore,
urgent
diagnose
problems
related
MP
detection.
Agriculture
and
food
systems
are
major
sources
of
plastic
pollution
but
they
also
vulnerable
to
their
diverse
lifecycle
impacts.
However,
this
problem
is
not
well-recognized
in
global
policy
scientific
discourse,
agendas,
monitoring
systems.
The
United
Nations-led
Global
Plastics
Treaty,
which
has
been
under
negotiation
since
2022,
a
critical
opportunity
address
across
the
entire
plastics
for
more
sustainable
resilient
Here,
we
offer
aspirational
indicators
future
systems'
related
(1)
polymers
chemicals,
(2)
land
use,
(3)
trade
waste,
(4)
environmental
human
health.
We
call
interdisciplinary
research
collaborations
continue
improving
harmonising
evidence
base
necessary
track
trace
chemicals
highlight
need
collaboration
disciplines
sectors
tackle
urgent
challenge
biodiversity,
climate
change,
security
nutrition,
health
rights
at
whole
level.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 2071 - 2071
Published: Feb. 27, 2025
Nanoplastics
(NPs)
represent
a
major
challenge
in
environmental
contamination
resulting
from
the
physical,
chemical,
and
biological
degradation
of
plastics.
Their
characterization
requires
advanced
expensive
methods,
which
limit
routine
analyses.
The
effects
NPs
depend
on
their
chemical
physical
properties,
influence
toxicity
interactions
with
systems.
Studies
animal
models,
such
as
Daphnia
magna
Danio
rerio,
show
that
induce
oxidative
stress,
inflammation,
DNA
damage,
metabolic
alterations,
often
related
to
charge
particle
size.
affect
endocrine
functions
by
acting
disruptors,
interfering
thyroid
sex
hormones
showing
potential
transgenerational
through
epigenetic
modifications,
including
hyper-
hypomethylation.
Behavioral
neurofunctional
alterations
have
been
observed
rerio
mouse
suggesting
link
between
NP
exposure
neurotransmitters
dopamine
serotonin.
Despite
limited
human
studies,
presence
breast
milk
placenta
underscores
need
for
further
investigation
health
effects.
Research
focusing
genetic
markers
is
encouraged
elucidate
molecular
mechanisms
risks
associated
chronic
exposure.
Frontiers in Cardiovascular Medicine,
Journal Year:
2025,
Volume and Issue:
12
Published: April 17, 2025
Hypertension
(HTN)
is
a
widespread
global
health
challenge,
and
its
increasing
prevalence
attributed
to
individual
environmental
risk
factors.
Persistent
organic
pollutants
(POPs),
especially
polychlorinated
biphenyls
(PCBs),
contribute
cardiovascular
by
accumulating
in
fatty
tissues,
which
leads
oxidative
stress
vascular
inflammation.
This
review
meta-analysis
aimed
investigate
the
association
between
PCB
exposure
hypertension.
Adhering
PRISMA
2020
guidelines,
data
sources
such
as
PubMed,
Scopus,
Web
of
Science,
Google
Scholar
were
systematically
searched
up
July
2024
find
observational
studies
on
link
PCBs
hypertension
risk.
Studies
reviewed
chosen
according
established
inclusion
exclusion
criteria,
focusing
examining
Independent
reviewers
conducted
extraction,
quality
was
evaluated
using
JBI
critical
appraisal
tool.
A
with
random-effects
model
determine
combined
odds
ratios
(ORs)
for
linked
total
specific
types.
Of
494
records
identified,
21
met
comprising
5
cohort
studies,
15
cross-sectional
one
case-control
study,
totaling
51,514
participants.
Exposure
correlated
an
elevated
(OR
=
1.78,
95%
CI:
1.30-2.44).
Dioxin-like
also
associated
heightened
1.54,
1.24-1.90),
while
non-dioxin-like
not
significantly
1.16,
0.81-1.66).
Among
congeners,
PCB-74,
PCB-118,
PCB-105,
PCB-153
related
higher
These
findings
indicate
positive
correlation
hypertension,
particularly
dioxin-like
certain
congeners.
Additional
research
necessary
clarify
mechanisms
involved
promote
measures
reducing
exposure,
high-risk
populations.
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024595223,
PROSPERO
(CRD42024595223).
