Sleeping Difficulties, Sleep Duration, and Risk of Hypertension in Women

Hypertension, Journal Year: 2023, Volume and Issue: 80(11), P. 2407 - 2414

Published: Sept. 18, 2023

Rates of poor sleep and hypertension are alarming worldwide. In this study, we investigate the association between sleeping difficulties duration with risk in women.

Language: Английский

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Relationship between the Biological Clock and Inflammatory Bowel Disease

Clocks & Sleep, Journal Year: 2023, Volume and Issue: 5(2), P. 260 - 275

Published: May 12, 2023

The biological clock is a molecular oscillator that generates 24-hour rhythm in accordance with the earth’s rotation. Physiological functions and pathophysiological processes such as inflammatory bowel diseases (IBD) are closely linked to clock. This review summarizes 14 studies humans mice on interactions between IBD. It provides evidence IBD negatively affect core gene expression, metabolism immune functions. On other hand, disruption of promotes inflammation. Overexpression genes can lead inhibition processes, while silencing irreversible disease activity. In both human mouse studies, circadian rhythms have been shown influence each other. Further research needed understand exact mechanisms develop potential rhythm-related therapies improve

Language: Английский

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A Survey on Blood Pressure Measurement Technologies: Addressing Potential Sources of Bias

Sensors, Journal Year: 2024, Volume and Issue: 24(6), P. 1730 - 1730

Published: March 7, 2024

Regular blood pressure (BP) monitoring in clinical and ambulatory settings plays a crucial role the prevention, diagnosis, treatment, management of cardiovascular diseases. Recently, widespread adoption BP measurement devices has been predominantly driven by increased prevalence hypertension its associated risks conditions. Recent guidelines advocate for regular as part visits or even at home. This utilization technologies raised significant concerns regarding accuracy reported values across settings. In this survey, which focuses mainly on cuff-based technologies, we highlight how measurements can demonstrate substantial biases variances due to factors such device errors, demographics, body habitus. With these inherent biases, development new generation that use artificial intelligence (AI) potential. We present future avenues where AI-assisted leverage extensive literature BP-related studies together with large collections records available electronic health records. These resources be combined machine learning approaches, including deep Bayesian inference, remove provide individualized risk indexes.

Language: Английский

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Circadian rhythms in cardiovascular (dys)function: approaches for future therapeutics

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)

Published: Sept. 23, 2024

Abstract The circadian clock is an evolutionarily conserved time-keeper that regulates physiological processes across 24 h. In the cardiovascular system, several parameters, such as blood pressure, heart rate, and metabolism, exhibit time-of-day variations. These features are in part driven by clock. Chronic perturbation of diurnal rhythmicity due to shift work or irregular social schedules has been associated with increased risk hypertension, arrhythmias, myocardial infarction. This review discusses impact rhythms on human health effect disruption occurrence adverse cardiac events. Additionally, we discuss how main factors diseases, obesity, sleep disorders, aging, affect rhythms. Finally, elaborate chronotherapy well targeting highlight novel approaches translate our scientific understanding into clinical practice.

Language: Английский

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Consistent Morning Exercise May Be Beneficial for Individuals With Obesity

Exercise and Sport Sciences Reviews, Journal Year: 2020, Volume and Issue: 48(4), P. 201 - 208

Published: July 10, 2020

This review explores the hypothesis that a consistent exercise time, especially morning exercise, improves adherence and weight management for individuals with overweight or obesity. We discuss data supporting this premise, identify limitations of current research, outline directions future research on timing to more robustly evaluate our thesis.

Language: Английский

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Myocardium Metabolism in Physiological and Pathophysiological States: Implications of Epicardial Adipose Tissue and Potential Therapeutic Targets

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(7), P. 2641 - 2641

Published: April 10, 2020

The main energy substrate of adult cardiomyocytes for their contractility are the fatty acids. Its metabolism generates high ATP levels at expense oxygen consumption in mitochondria. Under low supply, they can get from other substrates, mainly glucose, lactate, ketone bodies, etc., but mitochondrial dysfunction, pathological conditions, reduces oxidative metabolism. In consequence, acids stored into epicardial fat and its accumulation provokes inflammation, insulin resistance, stress, which enhance myocardium dysfunction. Some therapies focused on improvement entry mitochondria have failed to demonstrate benefits cardiovascular disorders. Oppositely, those with effects volume inflammation might improve reduce disease progression. This review aims explain (a) adaptation physiological (b) reduction conditions consequences (c) outcomes after regulation by some therapies.

Language: Английский

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Beneficial effects of exercise on chemotherapy-induced peripheral neuropathy and sleep disturbance: A review of literature and proposed mechanisms

Gynecologic Oncology Reports, Journal Year: 2022, Volume and Issue: 39, P. 100927 - 100927

Published: Jan. 7, 2022

The goal of this narrative review is to evaluate the literature regarding exercise training as a therapy prevent or mitigate deleterious side effects chemotherapy, specifically peripheral neuropathy and sleep disturbances make concrete recommendations for implementation practicing oncologist. A search was conducted studies that included an intervention be implemented patients undergoing previously treated with chemotherapy along analysis its effect on either chemotherapy-induced (CIPN) disturbances. Studies were subsequently analyzed summarized in order determine overall promise setting. Five met inclusion criteria assessed regard CIPN eight Exercise found significantly beneficial preventing, mitigating, improving symptoms cancer majority evaluated. effective should prescribed concurrently maximize potential avoiding these debilitating effects, which negatively impact quality life survivors.

Language: Английский

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Evaluating the Relationship between Circadian Rhythms and Sleep, Metabolic and Cardiovascular Disorders: Current Clinical Evidence in Human Studies

Metabolites, Journal Year: 2023, Volume and Issue: 13(3), P. 370 - 370

Published: March 1, 2023

Circadian rhythms are generated by the circadian clock, a self-sustained internal timing system that exhibits 24-h in body. Many metabolic, cellular, behavioral and physiological processes regulated clock coordination with environmental cues. The present study is comprehensive review of currently existing evidence concerning relationship between sleep, cardiovascular disorders. We thoroughly searched online databases PubMed, Scopus, Web Science to find clinical studies from last twenty-three years (2000–2023). misalignment was found be associated an increase risk metabolic disorders, diseases, obesity, as well inadequate sleep quality. In this article, all included had strength protocol design them were conducted on humans. However, most common limitations small sample size short time intervention. conclusion, managing factors disrupt optimal function central peripheral clocks can help reduce improving also Future should further explore underlying mechanisms interconnections This may provide new opportunities for advance chronotherapy approach.

Language: Английский

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Poor sleep quality and associated factors among community-dwelling older adult at Gondar town

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 8, 2025

Sleep disturbance poses a significant health concern for older adults, as it is associated with overall decline. Poor sleep quality increases the risk of chronic diseases, depression, anxiety, and diminished life. Therefore, this study aimed to assess prevalence poor its factors among adults living in community Gondar town, Northwest Ethiopia, 2023. A community-based cross-sectional was conducted town from February 20 April 30, assessed using Pittsburgh Quality Index (PSQI), validated tool. Data were coded Epi data version 3.0 analyzed STATA 14. Associated examined univariable multivariable logistic regression models. In total 845 participants involved 99.5% response rate. The elderly 54.6% 95% CI (51- 58%). Age ≥ 75 years [AOR = 3.88, CI: 2.11–7.10], social support 3.7, 2.35–5.81], physically inactive 4.42, 3.11–6.26], disease 2.45–5.55] depression 2.01, (CI: 1.42–2.83)] quality. 55% community-dwelling experience quality, particularly those advanced age, support. To address this, enhancing networking activities recommended. Engaging physical has shown significantly improve Healthcare providers should conduct regular screenings issues provide education about hygiene enhance adults. Future researchers are encouraged use Longitudinal studies explore impact communities.

Language: Английский

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Circadian Rhythmicity and 24/7 Operations

Current Sleep Medicine Reports, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 20, 2025

Language: Английский

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