The role of circadian clock in regulating cell functions: implications for diseases

MedComm, Journal Year: 2024, Volume and Issue: 5(3)

Published: March 1, 2024

Abstract The circadian clock system orchestrates daily behavioral and physiological rhythms, facilitating adaptation to environmental internal oscillations. Disruptions in rhythms have been linked increased susceptibility various diseases can exacerbate existing conditions. This review delves into the intricate regulation of diurnal gene expression cell function by clocks across diverse tissues. . Specifically, we explore rhythmicity expressions, behaviors, functions both immune non‐immune cells, elucidating regulatory effects mechanisms imposed clocks. A detailed discussion is centered on complex regulating key cellular signaling pathways. We further diseases, with a focus inflammatory cancers, systemic diseases. By highlighting intimate interplay between especially through clock‐controlled function, this contributes development novel disease intervention strategies. enhanced understanding holds significant promise for design targeted therapies that exploit improved treatment efficacy.

Language: Английский

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Targeting the intestinal circadian clock by meal timing ameliorates gastrointestinal inflammation

Cellular and Molecular Immunology, Journal Year: 2024, Volume and Issue: 21(8), P. 842 - 855

Published: June 25, 2024

Abstract The expression of clock genes has been observed to be impaired in biopsies from patients with inflammatory bowel disease (IBD). Disruption circadian rhythms, which occurs shift workers, linked an increased risk gastrointestinal diseases, including IBD. peripheral intestinal epithelial cells (IECs) was previously shown balance homeostasis by regulating the microbiome. Here, we demonstrated that is disrupted IBD-relevant mouse model ( IL-10 −/− ). A lack gene Bmal1 ) a chemically and novel genetically induced colitis (DSS, IEC−/− x promoted dramatically reduced survival rates. Germ-free mice colonized disease-associated microbiota exhibited responses, highlighting importance local for microbiota-induced IBD development. Targeting directly timed restricted feeding (RF) restored functions, immune cell recruitment microbial rhythmicity; improved responses; enhanced rates rescued histopathological phenotype. In contrast, RF failed improve symptoms mice, demonstrating significance determining beneficial effect RF. Overall, provide evidence dysfunction triggers host imbalance promotes development progression IBD-like colitis. Enhancing function modulates pathogenesis thus could become strategy ameliorate patients.

Language: Английский

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Circadian Rhythms in Anticancer Immunity: Mechanisms and Treatment Opportunities

Annual Review of Immunology, Journal Year: 2024, Volume and Issue: 42(1), P. 83 - 102

Published: June 28, 2024

Circadian rhythms of approximately 24 h have emerged as important modulators the immune system. These oscillations are for mounting short-term, innate responses, but surprisingly also long-term, adaptive responses. Recent data indicate that they play a central role in antitumor immunity, both mice and humans. In this review, we discuss evolving literature on circadian responses underlying mechanisms control them. We further provide an overview treatment regimens-chrono-immunotherapies-that harness time-of-day differences immunity optimal efficacy. Our aim is to researchers clinicians alike, better understanding system how best it chronotherapeutic interventions. This knowledge per se could revolutionize way approach cancer range other diseases, ultimately improving clinical practice.

Language: Английский

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Changes in delayed sleep patterns and related clinical factors in a social restriction environment

Chronobiology International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: Feb. 12, 2025

We aimed to investigate which factors, including socioenvironmental factors and emotional regulation, were associated with pronounced delayed sleep patterns during the COVID-19 social restriction. evaluated 744 adults aged 20-65 y using a web-based survey self-reported questionnaire in May 2022. Based on survey, we estimated mid-sleep time free days corrected for oversleeping (MSFsc) jet lag (SJL). determined ΔMSFsc, was defined as difference between MSFsc pre- mid-pandemic. The high-risk group (H-DSP) younger evening person had more severe insomnia, depression rumination, smartphone addiction (p < 0.05). Logistic regression revealed that stronger tendencies express emotions rumination independent risk pattern of pandemic. In H-DPS group, SJL increased even average duration decreased socially restricted environments, emotion regulation significantly affects severity patterns, people H-DSP also disrupted circadian rhythms. Therefore, active education hygiene support psychological interventions are needed environments.

Language: Английский

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MiceDEGdb: a knowledge base on differentially expressed mouse genes as a model object in biomedical research

Vavilov Journal of Genetics and Breeding, Journal Year: 2025, Volume and Issue: 29(1), P. 153 - 161

Published: March 4, 2025

The fundamental understanding of many biological processes that unfold in a human body has become possible due to experimental studies on animal models. backbone modern biomedical research is the use mouse models for studying important pathophysiological mechanisms, assessing new therapeutic approaches and making decisions acceptance or rejection candidate medicines preclinical trials. mice advantageous because they have small size, are easy keep genetically modify. Mice make up more than 90 % rodents used pharmaceutical research. We present pilot version MiceDEGdb, knowledge base genes differentially expressed as model object researc h. MiceDEGdb collection published data gene expression strains age-related diseases, such hypertension, pe rio dontal disease, bone fragility, renal fibrosis, smooth muscle remodeling, heart failure circadian rhythm disorder. release contains 21,754 DEGs representing 9,769 unique Mus musculus transcription levels whereof were found being changed 25 RNA-seq experiments involving eight tissues – gum, bone, kidney, right ventricle, aortic arch, hippocampus, skeletal uterus six genetic (C57BL/6J, Ren1cCre|ZsGreen, B6.129S7(Cg)-Polgtm1Prol/J, BPN/3J, BPH/2J Kunming) diseases all these based information 10 original articles. novel it features curated annotation changes using independent publications about same-direction homologs patients with one disease other. In its release, documented 85,092 annotations 318 895 suggest 912 scientific articles referenced by their PubMed ID. contained may be interest geneticists, molecular biologists, bioinformatics scientists, clinicians, pharmacologists advisors personalized medicine. freely available at https://www.sysbio.ru/MiceDEGdb .

Language: Английский

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Circadian Rhythm Dysregulation in Inflammatory Bowel Disease: Mechanisms and Chronotherapeutic Approaches

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3724 - 3724

Published: April 15, 2025

Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn’s (CD), is characterized by chronic intestinal inflammation. Recent research has highlighted the significant interplay between IBD pathogenesis circadian rhythms. This review synthesizes current evidence regarding regulation in IBD, covering three main areas: (1) rhythms physiology, (2) disruption patterns patients, (3) role of clock genes pathogenesis. We discuss how these findings may inform novel chronotherapeutic approaches for treatment. Future directions that could facilitate translation chronobiological insights into clinical applications are also explored.

Language: Английский

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Comprehensive integrative analysis of circadian rhythms in human saliva

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: May 10, 2025

Abstract The circadian clock orchestrates vital physiological functions, with its dysregulation implicated in various pathologies. Assessing human status via the measurement of rhythms is crucial for health management and disease treatment. Saliva provides a non-invasive means such analysis. In this study, we examined related parameters 21 healthy individuals ( n = 4 – 19 per experiment), assessing different data types, including saliva gene expression our TimeTeller ® methodology, hormone levels, cell composition, self-assessment tests chronotype evaluation. While substantial individual variability profiles was observed, found significant correlations between acrophases ARNTL1 cortisol, both correlated bedtime on sampling day. Our findings validate robustness reliability method determining peripheral humans, offering potential clinical applications diverse cohorts.

Language: Английский

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Chronodisruption and Gut Microbiota: Triggering Glycemic Imbalance in People with Type 2 Diabetes

Nutrients, Journal Year: 2024, Volume and Issue: 16(5), P. 616 - 616

Published: Feb. 23, 2024

The desynchronization of physiological and behavioral mechanisms influences the gut microbiota eating behavior in mammals, as shown both rodents humans, leading to development pathologies such Type 2 diabetes (T2D), obesity, metabolic syndrome. Recent studies propose resynchronization a key input controlling cycles contributing reducing risk suffering some chronic diseases diabetes, or In this analytical review, we present an overview how its implications for microbiome make people vulnerable intestinal dysbiosis consequent diseases. particular, explore eubiosis–dysbiosis phenomenon and, finally, topics aimed at addressing chronotherapy strategy prevention

Language: Английский

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PULSATILE DRUG DELIVERY SYSTEMS THE NOVEL APPROACH

International Journal of Pharmacy and Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: Feb. 1, 2024

Oral pulsatile drug delivery systems (PDDS) are intended to induce programmable lag phases before a quick and quantifiable, repeated, or prolonged medication release. As result, they gaining popularity due their inherent suitability for achieving chronotherapeutic goals, which have just been highlighted concerning several prevalent chronic illnesses characterized by typical night early-morning recurring symptoms (e. g. bronchial asthma, heart attack, rheumatoid arthritis, early-morningawakening). Furthermore, time-based colonic release is possible when devices correctly modified overcome unexpected gastric emptying give delay periods that roughly match the small intestine transit time. administration accomplished using platforms, including reservoir, capsular, osmotic devices. The current review article addressed topics followed: reason invented; diseases necessary; classification, advantages disadvantages; methods used in systems; situation nowadays its potential future; recent advancements, especially, previous five ten years of research on conducted researchers variety drugs diseases.

Language: Английский

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Effect of Intermittent Fasting on Immune Parameters and Intestinal Inflammation

Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3956 - 3956

Published: Nov. 19, 2024

Intermittent fasting (IF), including alternate day (ADF) and time-restricted feeding (TRF) or, in humans, eating (TRE), has been associated with the prevention improvement of diseases, inflammatory bowel disease (IBD). This review summarizes 20 animal human studies on influence IF intestinal inflammation. In studies, TRF ADF improved histological scores, markers, markers oxidative stress, microbiota composition. Apart from Ramadan fasting, there are no IBD patients, so healthy people were included. The showed almost effects, but this particular type is not directly comparable to TRE or ADF. However, appear have anti-inflammatory effects individuals, as they significantly reduce CRP levels markers. also composition circadian oscillation clock genes. beneficial depend number uninterrupted days while improvements colitis observed regardless duration fasting.

Language: Английский

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