Frontiers in Aging, Journal Year: 2025, Volume and Issue: 5
Published: Jan. 6, 2025
Memory formation is associated with constant modifications of neuronal networks and synaptic plasticity gene expression in response to different environmental stimuli experiences. Dysregulation affects memory during aging neurodegenerative diseases. Covalent such as methylation on DNA acetylation histones regulate the transcription genes. Changes these epigenetic marks correlated alteration aging. These modifications, turn, are regulated by physiology metabolism. Steroid hormone estrogen metabolites S-adenosyl methionine acetyl CoA directly impact histones' levels. Thus, decline levels or imbalance underlying brain functions. In present review, we discussed importance histone chromatin regulation consolidation, modulation modifiers phytochemicals vitamins. Further, understanding molecular mechanisms that modulate will help develop recovery approaches.
Language: Английский