Expert Review of Clinical Pharmacology,
Journal Year:
2023,
Volume and Issue:
16(12), P. 1187 - 1199
Published: Nov. 29, 2023
Introduction
Delayed
drug
hypersensitivity
reactions
(DDHRs)
represent
a
major
health
problem.
They
are
unpredictable
and
can
cause
life-long
disability
or
even
death.
The
pathophysiology
of
DDHRs
is
complicated,
multifactorial,
not
well
understood
mainly
due
to
the
lack
validated
animal
models
in
vitro
systems.
role
immune
system
demonstrated
but
its
exact
still
matter
debate.
Allergology International,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
The
detection
of
drug-specific
activation
T
cells
in
the
lymphocyte
transformation
test
(LTT)
is
mainly
based
on
cell
proliferation
or
cytokine
secretion.
However,
LTT
presents
with
a
varying
sensitivity
and
specificity.
aim
our
study
was
to
analyse
genome
wide
gene
expression
PBMC
identify
drug
allergy-specific
regulation
patterns.
Additionally,
differences
related
allergy-inducing
type
allergy
(immediate/delayed)
were
investigated.
Blood
samples
from
40
patients
different
drugs
non-drug-allergic
controls
recruited.
isolated
stimulated
culprit
("LTT-platform").
Transcriptome
analyses
conducted
after
3.5
days.
concentration
IFN-γ
IL-5
culture
supernatants
measured
by
ELISA
6
transcriptome
revealed
an
patients.
Importantly,
corresponding
control
groups
these
genes
barely
even
opposingly
regulated.
It
also
shown
that
particular
cefuroxime
exerted
strong
effect
PBMC.
Quantitative
RT-PCR
selected
identified
CCL17,
CISH
CD25
specifically
upregulated
Notably,
upregulation
did
not
necessarily
correlate
outcome
controls.
Our
results
could
be
helpful
for
identification
one
panel
regulated
considering
patient
specific
parameters
like
drug.
Cureus,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 19, 2025
Trimethoprim-sulfamethoxazole
(TMP-SMX)
is
a
non-β-lactam
antibiotic
commonly
used
in
pediatrics
to
treat
infections
and
as
prophylactic
medication.
Hypersensitivity
TMP-SMX
generally
non-immediate,
immediate
allergic
reactions,
including
anaphylaxis,
are
rare.
This
case
report
details
six-year-old
girl
who
experienced
anaphylaxis
TMP-SMX.
Her
skin
prick
test
with
was
negative,
but
she
developed
drug
provocation
(DPT).
An
additional
basophil
activation
(BAT)
for
the
combination
tablet
evaluated
confirmed
positive.
underscores
need
alternative
diagnostic
methods
like
BAT,
which
pose
lower
risk
than
DPT.
The
findings
suggest
that
BAT
could
offer
safer
approach,
though
more
studies
required
validate
its
use
allergy
diagnosis.
World Allergy Organization Journal,
Journal Year:
2024,
Volume and Issue:
17(9), P. 100946 - 100946
Published: Aug. 20, 2024
Drug
provocation
tests
(DPTs)
are
also
used
in
some
patients
with
a
history
of
contrast
medium
(CM)-hypersensitivity
reaction.
Since
the
use
agents
requires
special
knowledge
that
is
present
radiology
but
not
necessarily
allergology,
this
overview
should
close
gaps.
The
literature,
and
package
inserts
industry
dealing
DPTs
hypersensitivity
reactions
was
analyzed
results
presented.
Historical
analyses
revealed
were
already
done
past,
called
pre-testing.
Due
to
disadvantages,
diagnostic
tool
abandoned.
A
few
years
later,
DPT
introduced
as
an
innovative
procedure.
has
3
main
disadvantages:
missing
standardization,
at
risk
(such
compromised
renal
function)
rarely
taken
into
account,
negative
does
exclude
subsequent
CM
(formerly
pre-testing)
well-known
method
for
diagnosing
CM-related
reactions.
disadvantages
diagnosis
outweigh
advantages,
we
propose
replacing
routine
contrast-enhanced
imaging
examination
radiology.
Frontiers in Allergy,
Journal Year:
2025,
Volume and Issue:
6
Published: March 27, 2025
Introduction
Cefuroxime
allergy
may
present
as
a
delayed-type
reaction
or
an
immunoglobulin
(Ig)E-mediated
immediate-type
anaphylactic
reaction.
The
basophil
activation
test
(BAT)
is
diagnostic
tool
for
cefuroxime-induced
reactions,
whereas
the
lymphocyte
transformation
(LTT)
typically
applied
in
drug
allergy.
This
study
aimed
to
compare
results
of
BAT
and
LTT
15
patients
with
reactions
considered
confirmed.
pharmacoepidemiological
part
analyze
spontaneous
reports
cefuroxime-associated
European
adverse
database
(EudraVigilance).
Methods
In
EudraVigilance,
668
Economic
Area
(EEA)
between
2010
2023
were
analyzed,
182
(27.2%)
these
originating
from
Germany.
performed
according
standard
protocols.
Except
one
patient,
all
prior
skin
tests,
thereafter.
Results
Almost
classified
serious
(EEA,
99.3%;
Germany,
98.9%).
60.8%
66.9%
(Germany)
respective
information,
occurred
after
intravenous
administration.
was
12
(3/12
positive;
sensitivity
25%),
while
(7/15
46.7%).
Conclusions
Our
analysis
highlights
importance
almost
serious.
Neither
negative
nor
can
rule
out
sensitization
reactions.
Fundamental and Clinical Pharmacology,
Journal Year:
2024,
Volume and Issue:
38(5), P. 988 - 997
Published: April 8, 2024
Hypersensitivity
reactions
(HSR)
are
reported
for
the
macrolides,
lincosamides,
and
streptogramins
(MLS)
antibiotic
family.
Data
about
cross-reactivity
among
between
MLS
remain
scarce
or
controversial.
The
aim
of
this
study
was
to
provide
an
overview
hypersensitivity
cross-reactions
MLSs
based
on
data
extracted
from
French
National
Pharmacovigilance
Database
(FPVD).
Cases
HSR
January
1985
December
2019
were
FPVD
using
standardized
MedDRA
queries
(SMQ).
including
allergological
test
involving
multiple
giving
at
least
one
positive
result
included.
Of
8394
cases
reviewed,
149
mainly
involved
pristinamycin
(n
=
83;
53.2%)
spiramycin
31;
19.9%).
immediate
in
54
delayed
94
cases.
Skin
tests
represented
majority
performed
728;
84.7%),
followed
by
reintroduction
79;
9.2%).
Eighty-six
cross-reactivities
identified
62
(41.6%).
All
25
explorations
showed
cross-reactivities,
but
only
30/253
macrolides
(11.9%).
Cross-reactivities
three
observed
31/322
(9.6%)
explorations.
This
highlights
possibility
MLSs.
Dermatologists
allergologists
managing
patients
with
should
be
aware
a
risk
different
classes
perform
testing
before
recommending
alternative
antibiotic,
especially
severe
drug
