Journal of Atherosclerosis and Thrombosis,
Journal Year:
2016,
Volume and Issue:
24(1), P. 19 - 25
Published: Oct. 11, 2016
Statin
treatment
to
reduce
low-density
lipoprotein
cholesterol
(LDL-C)
is
associated
with
the
prevention
of
cardiovascular
events
in
Western
patients.
Similar
results
have
been
reported
studies
conducted
Japan.
However,
dose
statins
and
degree
LDL-C
reduction
achieved
are
different
between
Asian
In
addition,
there
limited
data
regarding
racial
differences
response
statins.
this
review,
Asians
Westerners
described.
BMJ Open,
Journal Year:
2016,
Volume and Issue:
6(2), P. e010080 - e010080
Published: Feb. 1, 2016
Objective
Japan's
2011
Fukushima
Daiichi
Nuclear
Power
Plant
incident
required
the
evacuation
of
over
a
million
people,
creating
large
displaced
population
with
potentially
increased
vulnerability
in
terms
chronic
health
conditions.
We
assessed
long-term
impact
on
diabetes,
hyperlipidaemia
and
hypertension.
Participants
considered
participants
annual
public
check-ups
from
2008
to
2014,
administrated
by
Minamisoma
City
Soma
City,
located
about
10–50
km
nuclear
plant.
Methods
Disease
risks,
measured
pre-incident
post-incident
relative
were
examined
compared
between
evacuees
non-evacuees/temporary-evacuees.
also
constructed
logistic
regression
models
assess
disease
risks
adjusted
for
covariates.
Results
Data
total
6406
individuals
aged
40–74
years
who
participated
both
at
baseline
(2008–2010)
one
or
more
analysed.
Regardless
evacuation,
significant
increases
risk
observed
diabetes
(relative
risk:
1.27–1.60
1.12–1.30,
respectively,
depending
status
year).
After
adjustment
covariates,
increase
was
significantly
greater
among
than
non-evacuees/temporary-evacuees
(OR
1.18,
95%
CI
1.06
1.32,
p<0.01).
Conclusions
The
singularity
this
study
is
that
following
disaster
found
be
associated
small
adults.
Our
findings
help
identify
discussion
points
planning,
including
preparedness,
response
recovery
measures,
applicable
future
disasters
requiring
mass
evacuation.
Journal of Advanced Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 1, 2024
Atherosclerosis
is
a
chronic
and
complex
disease
caused
by
lipid
disorder,
inflammation,
other
factors.
It
closely
related
to
cardiovascular
diseases,
the
chief
cause
of
death
globally.
Peroxisome
proliferator-activated
receptors
(PPARs)
are
valuable
anti-atherosclerosis
targets
that
showcase
multiple
roles
at
different
pathological
stages
atherosclerosis
for
cell
types
tissue
sites.
Aim
Review:
Considering
spatial
temporal
characteristics
evolution
atherosclerosis,
pharmacological
clinical
studies
PPARs
were
summarized
systematically
updated
under
in
vascular
cells
atherosclerosis.
Moreover,
selective
PPAR
modulators
PPAR-pan
agonists
can
exert
their
synergistic
effects
meanwhile
reducing
side
effects,
thereby
providing
novel
insight
into
future
drug
development
precise
spatial–temporal
therapeutic
strategy
targeting
PPARs.
Key
Scientific
Concepts
Based
on
we
have
proposed
importance
stage-
type-dependent
precision
therapy.
Initially,
improve
endothelial
cells'
dysfunction
inhibiting
inflammation
oxidative
stress
then
regulate
macrophages'
metabolism
polarization
fatty
streak.
Finally,
reduce
fibrous
cap
formation
suppressing
proliferation
migration
smooth
muscle
(VSMCs).
Therefore,
research
type-specific
mechanisms
provide
foundation
space–time
treatment.
demonstrated
several
drugs
or
compounds
activation
Selective
(that
specifically
activate
gene
subsets
PPARs)
cell-specific
effects.
Furthermore,
dual-
pan-PPAR
agonist
could
perform
better
role
balancing
efficacy
cells/tissue-specific
basis
therapy
Journal of Atherosclerosis and Thrombosis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Aims:
Obicetrapib
is
a
highly
selective
cholesteryl
ester
transfer
protein
(CETP)
inhibitor
shown
to
reduce
low-density
lipoprotein
cholesterol
(LDL-C)
and
apolipoprotein
B
(apoB),
when
taken
as
monotherapy
in
combination
with
ezetimibe
on
background
of
statins,
clinical
trials
predominantly
conducted
Northern
European/Caucasian
participants.
We
characterized
the
efficacy,
safety,
tolerability
obicetrapib
within
an
Asian-Pacific
region
population.
Journal of Atherosclerosis and Thrombosis,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Diabetes
mellitus,
particularly
type
2
diabetes
mellitus
(T2DM),
is
a
pervasive
chronic
disease
that
affects
millions
of
people
worldwide.
It
predisposes
individuals
to
range
severe
microvascular
and
macrovascular
complications,
which
drastically
impact
the
patient's
quality
life
increase
mortality
rates
owing
various
comorbidities.
This
extensive
review
explores
intricate
pathophysiology
underlying
diabetic
focusing
on
key
mechanisms,
such
as
atherosclerosis,
insulin
resistance,
inflammation,
endothelial
dysfunction.
also
highlights
recent
therapeutic
advancements,
including
introduction
SGLT2
inhibitors
GLP-1
receptor
agonists,
provide
benefits
beyond
glycemic
control
offer
cardiovascular
renal
protection.
Furthermore,
future
position
agonists
in
terms
prevention
diseases
will
be
discussed.
Considering
differences
secretion
capacity
between
Western
Asian
patients,
Japanese
we
propose
treatment
strategy
for
high-quality
Japan.
Journal of Cardiovascular Development and Disease,
Journal Year:
2025,
Volume and Issue:
12(2), P. 60 - 60
Published: Feb. 5, 2025
Vascular
endothelial
function
plays
an
important
role
in
the
pathogenesis
of
atherosclerosis.
The
reduction
low-density
lipoprotein
cholesterol
(LDL-C)
is
a
key
therapy
for
preventing
coronary
artery
disease
(CAD),
but
omega-3
fatty
acids
as
residual
risk
factors
CAD
remains
controversial.
We
studied
correlation
between
serum
acid
levels
and
patients
with
receiving
statin
examined
effect
eicosapentaenoic
(EPA)
on
function.
A
total
150
consecutive
(LDL-C
<
100
mg/dL)
were
enrolled.
Serum
measured,
was
assessed
by
flow-mediated
dilation
(FMD)
brachial
artery.
Subsequently,
65
impaired
FMD
(<6%)
low
EPA/arachidonic
(AA)
(<0.3)
administered
EPA,
reassessed
after
3
months.
multivariate
linear
regression
analysis
demonstrated
that
docosahexaenoic
(DHA)
EPA
plus
DHA
independent
determinants
%FMD
(β
=
0.214
0.163,
p
0.05,
respectively).
significantly
improved
(from
3.7
±
1.0%
to
4.1
1.0%,
0.05)
EPA/AA,
especially
EPA/AA
high
triglyceride
3.4
4.0
1.1%,
0.01).
associated
dysfunction
therapy.
improves
those
triglycerides.
Journal of Atherosclerosis and Thrombosis,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
We
evaluated
the
efficacy
and
safety
of
bempedoic
acid,
an
ATP-citrate
lyase
inhibitor,
at
doses
60,
120,
180
mg,
administered
for
12
weeks
in
conjunction
with
ongoing
treatments
(e.g.,
statin
and/or
other
lipid-modifying
therapy)
determined
phase
3
trial
dosage
Japanese
patients.
This
multicenter,
randomized,
double-blind,
placebo-controlled,
parallel-group,
2b
included
patients
hypercholesterolemia
risk
cardiovascular
events
inadequate
response
to
statins/statin
intolerance.
The
percentage
change
low-density
lipoprotein
cholesterol
(LDL-C)
from
baseline
week
was
calculated.
acid
60
120
placebo
groups
47,
46,
48,
47
patients,
respectively;
79%
had
statins
21%
Relative
(-1.9%),
LDL-C
reduction
significantly
greater
treatment
(least
squares
mean:
-10.6%;
-21.9%;
-21.3%;
p＜0.01
vs.
placebo).
Patients
intolerance
who
were
treated
showed
improved
levels
by
12.
incidence
treatment-emergent
adverse
higher
acid-treated
(60
57.4%;
54.3%;
58.3%)
than
group
(38.3%).
There
no
increasing
trend
doses.
Adverse
related
muscular
hepatic
disorders
infrequent,
new
or
worsening
cases
diabetes
reported.
elevated
confirmed.
mg
found
be
appropriate
a
trial.
BMC Geriatrics,
Journal Year:
2022,
Volume and Issue:
22(1)
Published: March 28, 2022
Abstract
Background
Several
prospective
Western
studies
have
reported
an
inverse
association
of
vegetable
and
fruit
intake
with
dementia
risk.
However,
there
is
limited
epidemiologic
evidence
in
Asians.
This
study
investigated
the
intakes
vegetables,
fruits,
their
nutrients
on
risk
incident
its
subtypes
a
Japanese
community.
Methods
A
total
1071
participants
(452
men
619
women)
aged
≥60
years
without
at
baseline
were
prospectively
followed
up
for
24
years.
Intakes
evaluated
using
70-item
semiquantitative
food
frequency
questionnaire
categorized
into
quartiles
separately
by
gender.
The
outcome
measure
was
development
subtypes—namely,
Alzheimer’s
disease
(AD)
vascular
(VaD).
estimates
computed
Cox
proportional
hazards
model.
Results
During
long-term
follow-up
period,
464
subjects
developed
dementia,
whom
286
had
AD
144
VaD.
Higher
associated
gradually
lower
developing
(both
P
-trend
<
0.05),
but
not
VaD,
after
adjusting
confounders.
Subjects
allocated
highest
quartile
27
31%
AD,
respectively,
than
those
lowest
quartile.
decreased
significantly
higher
vitamin
A,
riboflavin,
C,
magnesium,
calcium,
potassium
(all
0.05).
dietary
fiber
tended
to
be
(
=
0.07).
Meanwhile,
no
significant
associations
between
subtypes.
Conclusion
vegetables
constituent
older
adults.
diet
rich
may
beneficial
reducing
