Immunity debt: Hospitals need to be prepared in advance for multiple respiratory diseases that tend to co-occur

BioScience Trends, Journal Year: 2023, Volume and Issue: 17(6), P. 499 - 502

Published: Dec. 7, 2023

As SARS-CoV-2 transitions from a pandemic to an endemic presence, significant rise in respiratory diseases such as influenza and Mycoplasma pneumonia is challenging healthcare systems weakened by the impact of COVID-19. This commentary examines global resurgence pathogens, heightened post-pandemic "immunity debt", through analysis WHO surveillance data national health reports. Findings reveal substantial increase illnesses, notably among children, compounded shortage pediatricians growing antimicrobial resistance. underscores need improve hospital preparedness, optimize clinical responses, enhance public strategies effectively navigate impending peak concurrent infections.

Language: Английский

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Status of and perspectives on COVID-19 vaccination after lifting of the dynamic zero-COVID policy in China

Global Health & Medicine, Journal Year: 2023, Volume and Issue: 5(2), P. 112 - 117

Published: Feb. 10, 2023

On December 7, 2022, China's National Health Commission issued the Ten New Covid Rules lifting dynamic zero-COVID policy. In interim, vaccination campaigns continue to be promoted. We assessed potential impacts on status, perceptions, and attitudes toward COVID-19 vaccines via an online self-administered questionnaire. Among 1,170 participants, 1,142 (97.6%) participants were vaccinated against COVID-19, 51.8% (591/1,142) have already received booster. More than half of who ages 31 50 (51.8%). Participants believed following strategies could improve rate: timely feedback data (such as safety, efficacy, other issues public concern) from authoritative media (95.6%), increasing number sites availability using more convenient methods making appointment (95.2%), recommendations friends relatives (94.8%), presenting qualifications staff performing (89.1%). measures, including targeted measures for different age groups safety efficacy media, are likely help rates.

Language: Английский

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Characterization and trajectories of hematological parameters prior to severe COVID-19 based on a large-scale prospective health checkup cohort in western China: a longitudinal study of 13-year follow-up

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 7, 2024

The relaxation of the "zero-COVID" policy on Dec. 7, 2022, in China posed a major public health threat recently. Complete blood count test was discovered to have complicated relationships with COVID-19 after infection, while very few studies could track long-term monitoring status and identify characterization hematological parameters prior COVID-19.

Language: Английский

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For COVID-19, what are the priorities of normalized prevention and control strategies?

BioScience Trends, Journal Year: 2023, Volume and Issue: 17(1), P. 63 - 67

Published: Jan. 15, 2023

The COVID-19 pandemic has ravaged the world for three years. Most countries have adjusted policies and strategies in response to burden of COVID-19. severity seems be diminishing as case fatality rate declined number vaccinated people increased markedly. Given large population worldwide, we need pay attention continuing burden. Globally, cases remains at a certain level, is still increasing China. We also deal with shortages medical resources, antipyretics, home nursing facilities. SARS-CoV-2 will coexist humans long time, predicting viral mutations trends difficult. reform whole public health system imperative. A comprehensive surveillance should created determine proportion various pathogens guard against mixed infections respiratory infectious diseases. mechanism, including preventive measures treatments, soon possible monitor status epidemic long-term SARS-CoV-2.

Language: Английский

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Clinical features of febrile seizures in children with COVID-19: an observational study from a tertiary care hospital in China

Frontiers in Pediatrics, Journal Year: 2023, Volume and Issue: 11

Published: Oct. 6, 2023

Background Febrile seizures are a common neurologic manifestation in children with coronavirus disease 2019 (COVID-19). Compared to seasonal respiratory viruses, severe acute syndrome 2 (SARS-CoV-2) has pronounced neurological impact, the result that febrile COVID-19 may exhibit unique clinical features. Materials and methods We conducted retrospective study tertiary care hospital China. collected medical record information on COVID-19, including demographic characteristics, features, laboratory tests, burden. Subsequently, data were then analyzed descriptively. Results A total of 103 diagnosed positive PCR results included our study. Among them, 81 (78.6%) males 22 (21.4%) females. The age onset ranged from 14 57 months, mean 34.9 ± 6.24 months. Complex observed 34 (33%) cases. Antiseizure medications administered 24 (23.3%) patients. Laboratory tests showed white blood cell count (27.05 8.20) × 10 3 /µl, neutrophil (20.09 5.66) /µl lymphocyte (6.44 1.86) /µl. creatine kinase level was significantly elevated, value (412.00 158.96) U/L. length stay 4.36 days. Twelve patients (11.7%) required intensive services, but there no deaths or remaining antiseizure after discharge. Conclusion In post-epidemic era pediatric clinicians should be aware changing features associated COVID-19. average increased, higher proportion males. Length hospitalization costs did not increase significantly. prognosis remained favorable, although small number services during phase.

Language: Английский

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Socioeconomic inequalities in healthcare system efficiency in Japan during COVID-19 pandemic: an analysis of the moderating role of vaccination

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: March 21, 2024

Background In the context of COVID-19 pandemic, limited research has focused on socioeconomic disparities in Local Healthcare System Efficiency (LHSE) among Japanese prefectures. This study seeks to investigate moderating impact vaccination relationship between LHSE and characteristics endowments Methods To explore these relationships, we first utilized Data Envelopment Analysis with Slack-Based Measure measure LHSE, based data from prefectures during waves 2 5 pandemic. Then estimating variables LHSE. Finally, assessed changes way affect before after vaccine deployment using Seemingly Unrelated Estimation t-test methodology. Results The findings suggest an overall reduction across various regions due utilization vaccines. Particularly areas relatively nsufficient bed resources, a significant improvement was observed most regions. However, there no evidence supporting role mitigating inequalities Conversely, vaccines showed positive correlation proportion older adult population sufficient resources. facing shortages, enhancement became more reliant reducing occupancy rate secured beds for severe cases introduction vaccination. Discussion cases. underscores importance policymakers implementers prioritize treatment ensure effective supply medical particularly cases, their efforts improve post-COVID-19 era rising coverage.

Language: Английский

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Alpha and Delta variants and vaccination effectiveness against severity in COVID-19 inpatients based on medical claims in Japan

GHM Open, Journal Year: 2023, Volume and Issue: 3(1), P. 28 - 36

Published: July 15, 2023

Some mutated strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presumably have high infectivity and pathogenicity. Using Japanese medical claims data, we assessed the pathogenicity Alpha Delta variants vaccine effectiveness by severity. Inpatient records from Medical Information Analysis Databank for National Hospital Organization were used. Severity was defined as proportion inpatients using ventilators among with oxygen administration. We regressed severity fatality on patients or variant vaccination coverage, while allowing some lag to reflect development infection hospitalization. also examined results obtained when data all new inpatients, instead administration, denominator Estimation better administration than inpatients. Especially measures 65 years old older confirmed an association lower Vaccines most effective people older. The age distributions greater younger old. Vaccination reduced might increase receiving therapy.

Language: Английский

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The impact of comorbidity burden and age on the health-related quality-of-life of individuals one year after COVID-19 pneumonia

Kontakt, Journal Year: 2023, Volume and Issue: 25(4), P. 255 - 265

Published: Nov. 28, 2023

Úvod: Posouzení dlouhodobého dopadu koronaviru 2019 (COVID-19) na fyzickou a psychickou pohodu jednotlivců je zásadní často se měří prostřednictvím kvality života v kontextu zdraví (HRQOL). Cíl: Cílem výzkumu bylo prozkoumat subjektivní hodnocení zdravotního stavu pomocí nástroje Short Form 36 Health Survey (SF-36) u osob jeden rok po zápalu plic způsobeném koronavirem COVID-19 identifikovat dopad zátěže komorbiditou (kvantitativně hodnoceno Charlsonova indexu komorbidity [CCI]) věku ukazatelích fyzického psychického zdraví. Metody: Výzkum byl proveden telefonického průzkumu k vyhodnocení HRQOL 170 jedinců 20 ze srovnávací skupiny (CG). Výsledky: Výsledky ukazují významně nižší souhrnné ukazatele fyzické duševní složky III. IV. rizikové třídy ve srovnání s těmi, kteří měli zápal způsobený závažnosti II. rizika CG. Zároveň ukázal negativní vliv i Kromě toho celkový zdravotní stav vztahu rizikovým třídám III IV také II CCI ≥3 bodů než jedinců, 0-2 body. Závěr: Přítomnost počet komorbidit vyšší věk souvisí COVID-19. Proto prospektivní sledování vystavených SARS-CoV-2 rozpoznání potenciálních faktorů spojených špatnou pro pochopení vývoj personalizovaných strategií klinickou léčbu těchto cílem zlepšit kvalitu jejich života.

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