Impact of the COVID‐19 pandemic on the circulation of other pathogens in England DOI

Lauren Hayes,

Hannah Uri,

Denisa Bojková

et al.

Journal of Medical Virology, Journal Year: 2022, Volume and Issue: 95(1)

Published: Dec. 13, 2022

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by authors. Any queries (other than missing content) should be directed to corresponding author article.

Language: Английский

Mathematical Modeling and Sensitivity Analysis of COVID-19 and Tuberculosis Coinfection with Vaccination DOI Creative Commons
Jonner Nainggolan, Moch. Fandi Ansori

Mathematical Modelling and Engineering Problems, Journal Year: 2024, Volume and Issue: 11(1), P. 34 - 46

Published: Jan. 30, 2024

This research combines the COVID-19 and BCG vaccination subpopulations to examine spread of coinfection tuberculosis (TB) using a compartmental mathematical model.The model analysis yields non-endemic endemic equilibrium points in addition basic reproduction number.The variable can reduce incidence COVID-19, TB, coinfection.A sensitivity elasticity index is conducted result that natural death rate parameter most influential relation accelerated co-infection with tuberculosis.Additionally, we conduct timedependent determine how varying values influence each subpopulation.By this technique, calculate after reaching several groups parameters, resusceptible, immunity rate, symptomatic transition recovery are for group parameters on dynamics subpopulation.

Language: Английский

Citations

2
Human resource implications of expanding latent tuberculosis patient care activities DOI Creative Commons
Hannah Alsdurf,

Andrea Benedetti,

Tran N. Buu

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 10

Published: Jan. 12, 2024

The World Health Organization (WHO) declared increasing services for latent tuberculosis infection (LTBI) a priority to eliminate (TB) by 2035. Yet, there is little information about thehuman resource needs required implement LTBI treatment scale-up. Our study aimed estimate the change in healthcare workers (HCW) time spent on different patient care activities, following an intervention strengthen services.

Language: Английский

Citations

2
Ensuring Continuity of Tuberculosis Care during Social Distancing through Integrated Active Case Finding at COVID-19 Vaccination Events in Vietnam: A Cohort Study DOI Creative Commons
Luong Van Dinh, Luan Nguyen Quang Vo, Anja Maria Christine Wiemers

et al.

Tropical Medicine and Infectious Disease, Journal Year: 2024, Volume and Issue: 9(1), P. 26 - 26

Published: Jan. 22, 2024

COVID-19 significantly disrupted tuberculosis (TB) services in Vietnam. In response, the National TB Program (NTP) integrated screening using mobile chest X-rays into vaccination events. This prospective cohort study evaluated model’s yield, treatment outcomes, and costs. We further fitted regressions to identify risk factors conduct interrupted time-series analyses area, Vietnam’s eight economic regions, at national level. At 115 events, we conducted 48,758 X-ray screens detected 174 individuals with TB. linked 89.7% care, while 92.9% successfully completed treatment. The mean costs per person diagnosed was $547. included male sex (aOR = 6.44, p < 0.001), age of 45–59 years 1.81, 0.006) ≥60 1.99, 0.002), a history 7.96, prior exposure 3.90, symptomatic presentation 2.75, 0.001). There significant decline notifications during Delta wave increases immediately after lockdowns were lifted (IRR(γ1) 5.00; 95%CI: (2.86, 8.73); 0.001) continuous upward trend thereafter (IRR(γ2) 1.39; (1.22, 1.38); Similar patterns observed level all regions but northeast region. NTP’s swift actions policy decisions ensured continuity care led rapid recovery notifications, which may serve as blueprint for future pandemics.

Language: Английский

Citations

2
The crystal structure of the EspB-EspK virulence factor-chaperone complex suggests an additional type VII secretion mechanism in Mycobacterium tuberculosis DOI Creative Commons
Abril Gijsbers, Mathias Eymery, Ye Gao

et al.

Journal of Biological Chemistry, Journal Year: 2022, Volume and Issue: 299(1), P. 102761 - 102761

Published: Dec. 1, 2022

Pathogenic species from the Mycobacterium genus are responsible for a number of adverse health conditions in humans and animals that threaten security economy worldwide. Mycobacteria have up to five specialized secretion systems (ESX-1 ESX-5) transport virulence factors across their complex cell envelope facilitate manipulation environment. In pathogenic species, these influence immune system's response membrane disruption contributing death. While structural details been recently described, gaps still remain understanding mechanisms most substrates. Here, we describe crystal structure tuberculosis ESX-1 secretion-associated substrate EspB bound its chaperone EspK. We found interacts with C-terminal domain EspK through helical tip. Furthermore, cryogenic electron microscopy, size exclusion chromatography analysis, small-angle X-ray scattering experiments show keeps secretion-competent monomeric form prevents oligomerization. The presented this study suggests an additional mechanism ESX-1, analogous chaperoning proline-glutamate (PE)-proline-proline-glutamate (PPE) proteins by EspG, where facilitates species.

Language: Английский

Citations

9
Impact of the COVID‐19 pandemic on the circulation of other pathogens in England DOI

Lauren Hayes,

Hannah Uri,

Denisa Bojková

et al.

Journal of Medical Virology, Journal Year: 2022, Volume and Issue: 95(1)

Published: Dec. 13, 2022

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by authors. Any queries (other than missing content) should be directed to corresponding author article.

Language: Английский

Citations

9