Honey and propolis for management of diabetic foot ulcers DOI
Abdul Hafeez,

Hamouda SM

International Journal of Complementary & Alternative Medicine, Journal Year: 2024, Volume and Issue: 17(5), P. 240 - 246

Published: Jan. 1, 2024

Diabetes mellitus (DM) hyperglycemia may lead to hyperplasia and micro vascular dysfunction delays wound healing process by increasing reactive oxygen species (ROS) accompanied low levels of inflammatory cytokines an increase in matrix metalloproteinases (MMPs). Consequently, prolonged with the worst complication diabetic foot ulcers (DFUs) as when it fails heal fating limb amputation. Apitherapeutic (honey propolis) dressing achieved successful accelerated infection control action their antimicrobial, anti-inflammatory antioxidant properties. The present review dealt activity DFUs study of: vitro antimicrobial against isolated pathogens, towards immune cellular elements vivo application for induced animal models well topical patients either natural or nanoformulated scaffold dressings. Available literatures proved synergistic different mixed apitherapeutic products together recommended be used formula naturally nanoformulation.

Language: Английский

Potential Strategies for Overcoming Drug Resistance Pathways Using Propolis and Its Polyphenolic/Flavonoid Compounds in Combination with Chemotherapy and Radiotherapy DOI Open Access
Nada Oršolić, Maja Jazvinšćak Jembrek

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3741 - 3741

Published: Oct. 31, 2024

Conventional cancer treatments include surgical resection, chemotherapy, hyperthermia, immunotherapy, hormone therapy, and locally targeted therapies such as radiation therapy. Standard often require the use of multiple agents, which can activate nuclear factor kappa B (NF-κB) in tumor cells, leading to reduced cell death increased drug resistance. Moreover, agents also contributes added toxicity, resulting poor treatment outcomes. Cancer cells gradually develop resistance almost all chemotherapeutics through various mechanisms, efflux, alterations metabolism transport, changes signal transduction pathways, enhanced DNA repair capacity, evasion apoptosis, mutations, reactivation targets, interaction with microenvironment, cell-stroma interactions, epithelial–mesenchymal transition (EMT)-mediated chemoresistance, epigenetic modifications, metabolic alterations, effect stem (CSCs). Developing new strategies improve chemotherapy sensitivity while minimizing side effects is essential for achieving better therapeutic outcomes enhancing patients’ quality life. One promising approach involves combining conventional propolis its flavonoids. These natural compounds may enhance response reducing toxicity. Propolis components sensitize chemotherapeutic likely by inhibiting NF-κB activation, reprogramming tumor-associated macrophages (TAMs; an M2-like phenotype), thereby release matrix metalloproteinase (MMP)-9, cytokines, chemokines, vascular endothelial growth (VEGF). By TAMs, overcome EMT-mediated disrupt crosstalk between CSCs, inhibit maintenance stemness, reverse acquired immunosuppression, thus promoting antitumor mediated cytotoxic T-cells. This review highlights potential flavonoids modulate responsiveness modalities. The evidence suggests that novel incorporating could be developed positive cytotoxicity peripheral blood leukocytes, liver, kidney cells. Therefore, polyphenolic/flavonoid hold combination clinical types cancers.

Language: Английский

Citations

7
Linoleic Fatty Acid from Rwandan Propolis: A Potential Antimicrobial Agent Against Cutibacterium acnes DOI Creative Commons
Florent Rouvier,

Lydia Abou,

Emmanuel Wafo

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 162 - 162

Published: Feb. 27, 2025

Acne is a very common skin condition that causes pimples in 80% of adolescents despite the many effective treatments developed. Various compounds have been employed treatment acne, including erythromycin ointments and antiseptics, yielding mixed results. The rise erythromycin-resistant C. acnes strains has driven pursuit new antimicrobial agents, especially those obtained from natural sources. Propolis was collected Rwanda extracted, fractioned, analyzed for its activity against growth accordance with NCLSI guidelines. Our work revealed linoleic acid significant effect on at low concentration (16 µg/mL). A comparison activities broad panel well-known fatty acids specific mode action acid, characterized by membranotropic Bacillus cereus established measuring extracellular ATP levels as an indicator membrane permeability. data suggest could be promising candidate developing propolis-based ointment acne treatment.

Language: Английский

Citations

0
Exploring the antidiabetic effect of various therapeutic essential oils synergistically with repaglinide DOI
Omnia M. Sarhan,

Samaa O Abdelqader,

Mostafa Saad Mostafa

et al.

Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 103721 - 103721

Published: March 1, 2025

Language: Английский

Citations

0
Ethiopian honeybee propolis: a novel natural source for the green synthesis of silver nanoparticles with enhanced biological activities DOI Creative Commons
Gemechis Waktole, Bayissa Chala, Abebe Belay

et al.

Frontiers in Nanotechnology, Journal Year: 2025, Volume and Issue: 7

Published: April 24, 2025

Propolis, a natural resinous substance produced by honeybees ( Apis mellifera L.), is complex mixture of over 300 bioactive compounds with significant pharmaceutical potential. In light the escalating global antimicrobial resistance crisis, there an urgent need for novel agents. This study aimed to synthesize and characterize silver nanoparticles (AgNPs) using Ethiopian propolis evaluate their antioxidant properties. The synthesis propolis-mediated (Pro-AgNPs) was optimized characterized UV-visible spectrophotometry, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD). UV-Vis spectra revealed maximum absorbance at 424 nm, confirming successful AgNPs. FT-IR analysis identified functional groups involved in nanoparticle stabilization, while XRD confirmed crystalline nature nanoparticles. SEM images spherical-shaped uniform size distribution. activity Pro-AgNPs evaluated against Gram-negative Pseudomonas aeruginosa (ATCC 27853) Gram-positive Enterococcus faecalis 29212) bacteria, demonstrating growth inhibition zones 15.67 ± 0.57 mm 17.33 1.15 mm, respectively, concentration 50 μg/mL. extract 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, revealing concentration-dependent radical scavenging activity. exhibited potent activity, IC50 value 45.54 These findings underscore potential as antimicrobials antioxidants, promising applications pharmaceuticals, cosmetics, food industry.

Language: Английский

Citations

0
Propolis extract nanoparticles alleviate diabetes-induced reproductive dysfunction in male rats: antidiabetic, antioxidant, and steroidogenesis modulatory role DOI Creative Commons

Abram B. Emil,

Neven H. Hassan, Sally Ibrahim

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 23, 2024

Abstract Diabetes can affect male fertility via oxidative stress and endocrine system disruption. Nanomedicine based on natural products is employed to address diabetes complications. The current study aims investigate the potential beneficial effect of propolis extract nanoparticles against diabetes-induced testicular damage in rats. Sixty rats were randomly allocated six groups ( n = 10). first group served as a control group. second third received (Pr) (PrNPs). fourth diabetic that streptozotocin (STZ) (55 mg kg/bwt) single-dose i/p. fifth sixth are treated with Pr PrNPs. Both PrNPs at dose (100 mg/kg bwt) orally. After 60 days, animals euthanized, then pancreatic tissues collected for redox status evaluation, gene expression analysis, histopathological examination. Also, hormonal analysis (Insulin, total testosterone, luteinizing hormone (LH) ) along semen quality evaluation done. Results showed induction led deterioration showing reduction reduced glutathione (GSH) well elevation malondialdehyde (MDA), nitric oxide (NO) levels. relative transcript levels cytochrome P450 family 11 subfamily A member 1 (CYP11A1) , 3β-Hydroxysteroid dehydrogenase (HSD-3β) nuclear factor (erythroid-derived 2)-like 2 (NFE2L2) significantly down-regulated, While advanced glycation end-product receptor (AGER) was upregulated. Furthermore, disturbances observed. Upon treatment PrNPs, marked upregulation CYP11A1 HSD-3β NFE2L2 downregulation AGER, Hormones improved. In addition, enhanced. confirmed investigations. outperformed terms steroidogenesis pathway improvement, antioxidant defense mechanism augmentation, prospective antidiabetic activity.

Language: Английский

Citations

2
Network Pharmacology and Bioinformatic Integrative Analysis Reveals Candidate Gene Targets and Potential Therapeutic of East Kalimantan Propolis against Hepatocellular Carcinoma DOI Creative Commons
Paula Mariana Kustiawan, Khalish Arsy Al Khairy Siregar, Muhammad Miftah Jauhar

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(21), P. e39142 - e39142

Published: Oct. 19, 2024

Language: Английский

Citations

1
The evaluation of antioxidant activity of cinnamon bark (Cinnamomum burmannii) nanopowder in comparison with extracts DOI

Tiara Fahmawati,

Roro Intan Sasmaya Akbar,

Nofa Mardia Ningsih Kaswati

et al.

Materials Today Proceedings, Journal Year: 2024, Volume and Issue: unknown

Published: March 1, 2024

Language: Английский

Citations

0
Honey and propolis for management of diabetic foot ulcers DOI
Abdul Hafeez,

Hamouda SM

International Journal of Complementary & Alternative Medicine, Journal Year: 2024, Volume and Issue: 17(5), P. 240 - 246

Published: Jan. 1, 2024

Diabetes mellitus (DM) hyperglycemia may lead to hyperplasia and micro vascular dysfunction delays wound healing process by increasing reactive oxygen species (ROS) accompanied low levels of inflammatory cytokines an increase in matrix metalloproteinases (MMPs). Consequently, prolonged with the worst complication diabetic foot ulcers (DFUs) as when it fails heal fating limb amputation. Apitherapeutic (honey propolis) dressing achieved successful accelerated infection control action their antimicrobial, anti-inflammatory antioxidant properties. The present review dealt activity DFUs study of: vitro antimicrobial against isolated pathogens, towards immune cellular elements vivo application for induced animal models well topical patients either natural or nanoformulated scaffold dressings. Available literatures proved synergistic different mixed apitherapeutic products together recommended be used formula naturally nanoformulation.

Language: Английский

Citations

0