Interaction between gut virome and microbiota on inflammatory bowel disease DOI
Xiaolong Li,

Mueen Megdadi,

Humair S. Quadri

et al.

World Journal of Methodology, Journal Year: 2025, Volume and Issue: 15(3)

Published: March 6, 2025

Inflammatory bowel disease (IBD), encompassing Crohn's and ulcerative colitis, is a chronic condition marked by recurring gastrointestinal inflammation. While immune, genetic, environmental factors are well-studied, the gut virome has received less attention. This editorial highlights work which investigates virome’s role in IBD its interactions with bacterial microbiome host immune system. The consists of bacteriophages, eukaryotic viruses, endogenous retroviruses. Among these, Caudovirales bacteriophages predominant influence communities via lysogenic lytic cycles. Eukaryotic viruses infect cells directly, while retroviruses impact gene regulation responses. In IBD, shows distinct alterations, including an increased abundance phages reduced Microviridae diversity, suggesting pro-inflammatory viral environment. Dysbiosis, inflammation, aberrant responses contribute to these changes disrupting microbial modifying composition. Phages affect dynamics through lysis, lysogeny, horizontal transfer, shaping adaptability resilience. Understanding crucial for identifying novel therapeutic targets restoring balance IBD.

Language: Английский

Biosimilars versus biological therapy in inflammatory bowel disease: challenges and targeting strategies using drug delivery systems DOI Creative Commons
Ahmed Aljabri, Ghareb M. Soliman, Yasmin N. Ramadan

et al.

Clinical and Experimental Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 5, 2025

Abstract Inflammatory bowel disease (IBD) is a multifactorial illness with climbing prevalence worldwide. While biologics are commonly prescribed especially for severe cases, they may worsen patients’ outcomes due to financial burden. Consequently, there has been an increased focus on biosimilars improve overall by maintaining similar efficacy and safety while minimizing the cost of therapy. Infliximab-dyyb was first biosimilar approved US-FDA IBD. Since that, 14 different mechanisms action routes administration IBD patients (four infliximab biosimilars, nine adalimumab most recently one ustekinumab biosimilar). It should be noted that more in pipeline as golimumab natalizumab patents set expire near future, now pre-clinical phase 3 trials. Different studies have evaluated biologics' effectiveness concluded majority available efficacious adverse effect profiles compared their reference biologics. worth mentioningthat post-marketing surveillance reports revealed some risks associated which taken into consideration future research clinical trials avoid health hazards. Most administered parenterally results several drawbacks such raised risk infections, hypersensitivity, autoimmunity, development malignancies, liver toxicity well worsening heart failure. Several drug delivery systems based passive active targeting under investigation overcome these limitations. This review sheds light emergence alternatives management, differences between them, challenges risks, perspectives therapy new trends systems. Graphical

Language: Английский

Citations

1
Microbiome Gut-Brain-Axis: Impact on Brain Development and Mental Health DOI Creative Commons
Yasmin N. Ramadan, Saleh F Alqifari, Khaled Alshehri

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Abstract The current discovery that the gut microbiome, which contains roughly 100 trillion microbes, affects health and disease has catalyzed a boom in multidisciplinary research efforts focused on understanding this relationship. Also, it is commonly demonstrated CNS are closely related bidirectional pathway. A balanced microbiome essential for regular brain activities emotional responses. On other hand, regulates majority of GI physiology. Any disruption pathway led to progression problems both directions, neurological gastrointestinal diseases. In review, we hope shed light complicated connections microbiome-gut-brain axis critical roles early development order get deeper knowledge microbiome-mediated pathological conditions management options through rebalancing microbiome.

Language: Английский

Citations

0
Gut virome and its emerging role in inflammatory bowel disease DOI

Rahat Khatoon Khokhar,

Abdulqadir J. Nashwan

World Journal of Methodology, Journal Year: 2025, Volume and Issue: 15(3)

Published: March 6, 2025

Inflammatory bowel disease (IBD) is a progressive multifactorial inflammatory of the gut. The cause IBD yet unknown. Some researchers have shown that genetic factors, environmental and gut microbiome are significant considerations. Our contains virome bacteria, which vary among individuals due to some factors. substantial component microbiome. This editorial explores emerging role in IBD.

Language: Английский

Citations

0
Interaction between gut virome and microbiota on inflammatory bowel disease DOI
Xiaolong Li,

Mueen Megdadi,

Humair S. Quadri

et al.

World Journal of Methodology, Journal Year: 2025, Volume and Issue: 15(3)

Published: March 6, 2025

Inflammatory bowel disease (IBD), encompassing Crohn's and ulcerative colitis, is a chronic condition marked by recurring gastrointestinal inflammation. While immune, genetic, environmental factors are well-studied, the gut virome has received less attention. This editorial highlights work which investigates virome’s role in IBD its interactions with bacterial microbiome host immune system. The consists of bacteriophages, eukaryotic viruses, endogenous retroviruses. Among these, Caudovirales bacteriophages predominant influence communities via lysogenic lytic cycles. Eukaryotic viruses infect cells directly, while retroviruses impact gene regulation responses. In IBD, shows distinct alterations, including an increased abundance phages reduced Microviridae diversity, suggesting pro-inflammatory viral environment. Dysbiosis, inflammation, aberrant responses contribute to these changes disrupting microbial modifying composition. Phages affect dynamics through lysis, lysogeny, horizontal transfer, shaping adaptability resilience. Understanding crucial for identifying novel therapeutic targets restoring balance IBD.

Language: Английский

Citations

0