Clinical Use of the ImmunoCAP Inhibition Test in the Diagnosis of Meat Allergy Caused by a Tick Bite in an Adult Male with No Previous Atopic History

Life, Journal Year: 2023, Volume and Issue: 13(3), P. 699 - 699

Published: March 5, 2023

(1) Background: alpha-gal syndrome (AGS) is a serious, potentially life-threatening allergic reaction. This type of food allergy to red meat and other mammalian products (e.g., gelatin). In Poland, this problem seems be rare or, more likely, very underdiagnosed. The diagnosis AGS difficult. It that the knowledge about insufficient. There are no effective diagnostic tools able clearly diagnose cross-reactive allergy. paper presents clinical application non-standard method in using example AGS. (2) Methods: standard tests for vitro diagnostics ImmunoCAP inhibition test(IT) were carried out serum collected from patient with (3) Results: concentration anti-α-Gal IgE was high (302 kUA/L), antibodies toanti-mammalian-meat allergens found. level decreased after blocking on α-GAL-CAP. CAPs coated various allergens. Blocking poultry did not affect IgE. (4) Conclusions: ITseems useful tool allergies. Based their history test results, diagnosed caused by primary sensitization α-Gal tick bite. second case described Poland first Pomerania.

Language: Английский

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Qualitative and quantitative comparison of allergen component-specific to birch and grass analyzed by ImmunoCAP assay and Euroline immunoblot test

European Annals of Allergy and Clinical Immunology, Journal Year: 2022, Volume and Issue: 55(02), P. 68 - 68

Published: Jan. 14, 2022

Background.In the diagnostic work up of allergy, determining allergen component-specific immunoglobulin E (IgE) is important for diagnosis, prognosis and choice treatment. The purpose this study was to evaluate performance immunoblotting assay (Euroline) in detection IgE antibodies against timothy grass birch pollen components compared fluorescent enzyme (ImmunoCAP, Phadia 250). Methods. A total 128 serum samples from patients allergic were analysed. levels measured using Euroline DPA-Dx 1 ImmunoCAP assay. two methods then on binary (positive vs negative), semi-quantitative (IgE classes) quantitative (concentration) levels. also results skin prick testing. Results. method showed a positive percentage agreement 93% negative 94% with an overall accuracy when ImmunoCAP. Kappa analysis moderate strength between classes 7/11 tested. All correlation analysed Spearman's rank correlation. Conclusions. Overall, we found that there good measuring sensitization.

Language: Английский

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Diagnostic Workup in IgE-Mediated Allergy to Asteraceae Weed Pollen and Herbal Medicine Products in Europe

Medicina, Journal Year: 2024, Volume and Issue: 60(9), P. 1494 - 1494

Published: Sept. 13, 2024

Anemophilous weeds from the Asteraceae family are highly allergenic and represent a significant source of aeroallergens in late summer autumn. Ragweed mugwort pollen allergies have become health burden Europe. Some people with respiratory to weed may also suffer hypersensitivity reactions herbal medicines obtained certain cross-reactive plants Compositae family, such as chamomile, marigold, purple coneflower. General physicians, ear, nose, throat (ENT) specialists, pulmonologists need be familiar diagnostic tests used by allergists clinical practice support accurate diagnosis patients. Allergists must aware suggestions European Medicines Agency (EMA)'s Herbal Medicinal Products Committee broad spectrum therapies educate their patients about potential risks.

Language: Английский

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Diagnosis of Skin Diseases

Published: Jan. 1, 2024

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Biomarkers for the Molecular Diagnosis of IgE-Mediated Hymenoptera Venom Allergy in Clinical Practice

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 270 - 270

Published: Dec. 31, 2024

Hymenoptera venom allergy (HVA) is a potentially life-threatening condition, making accurate diagnosis crucial for identifying significant IgE sensitizations and enabling effective immunotherapy. In this review, we provide detailed overview of biomarkers the molecular IgE-mediated hypersensitivity to insect venoms in clinical practice, present, structured manner, their importance differentiating genuine versus cross-sensitizations using different diagnostic procedures. Updated algorithms are provided, along with advantages limitations approaches. Geographical variations rare species may pose further challenges diagnosing treating HVA, adding complexity HVA management. This review informs readers about performing tailored diagnostics based on allergen subsequent treatment strategies.

Language: Английский

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