Annals of the American Thoracic Society,
Journal Year:
2022,
Volume and Issue:
20(1), P. 131 - 135
Published: Dec. 31, 2022
"Acetazolamide
as
an
Adjunct
to
Positive
Airway
Pressure
Therapy
in
the
Treatment
of
Combined
Central
and
Obstructive
Sleep
Apnea."
Annals
American
Thoracic
Society,
20(1),
pp.
131–135
Journal of Clinical Sleep Medicine,
Journal Year:
2024,
Volume and Issue:
20(10), P. 1705 - 1710
Published: June 25, 2024
We
report
a
case
of
severe
central
sleep
apnea
incidentally
diagnosed
during
polysomnography
for
suspected
obstructive
apnea.
Characteristic
clinical
features
included
episodic
hyperventilation
followed
by
from
hypocapnia,
which
did
not
follow
Cheyne-Stokes
pattern.
Combined
with
the
identification
cerebellar
and
brainstem
malformations
known
as
"molar
tooth
sign"
on
brain
magnetic
resonance
imaging,
developmental
delay,
motor
coordination
problems,
Joubert
syndrome
(a
congenital
disease)
was
first
at
age
50
years.
Central
apneas
were
also
observed
wakefulness,
although
continuously.
During
sleep,
continuous
positive
airway
pressure
adaptive
servo-ventilation
ineffective
referring
clinic
our
hospital.
Supplemental
oxygen
decreased
frequency
significantly
shortened
duration
each
compared
room
air.
In
contrast,
opposite
response
acetazolamide
administration.
Expert Opinion on Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
24(18), P. 1963 - 1973
Published: Dec. 12, 2023
Introduction
Clinical
presentation
of
both
insomnia
and
obstructive
sleep
apnea
(COMISA)
is
common.
Approximately
30%
clinical
cohorts
with
OSA
have
symptoms
vice
versa.
The
underlying
pathophysiology
COMISA
multifactorial.
This
poses
a
complex
challenge.
Currently,
there
are
no
guidelines
or
recommendations
outside
continuous
positive
airway
pressure
(CPAP)
therapy
cognitive
behavioral
for
(CBTi).
Clinically
translatable
precision
medicine
approaches
to
characterize
individual
causes
endotypes
may
help
optimize
future
pharmacological
management
COMISA.
Somnologie - Schlafforschung und Schlafmedizin,
Journal Year:
2021,
Volume and Issue:
25(4), P. 294 - 300
Published: Nov. 22, 2021
Zusammenfassung
Die
obstruktive
Schlafapnoe
(OSA)
kann
zu
einer
erheblichen
Einschränkung
der
Lebensqualität
führen,
und
eine
nicht
behandelte
mittel-
bis
schwergradige
OSA
(Apnoe-Hypopnoe-Index
≥
15/h)
erhöht
das
Risiko
vieler
–
überwiegend
kardiovaskulärer
Erkrankungen
deutlich.
In
Anbetracht
Häufigkeit
des
Krankheitsbilds
damit
verbundenen
Beeinträchtigungen
ist
effektive
Diagnostik
Therapie
von
besonderer
Bedeutung.
Deutsche
Gesellschaft
für
Schlafforschung
Schlafmedizin
(DGSM)
hat
daher
jeweils
fünf
praxisnahe
Positiv-
Negativempfehlungen
zusammengestellt,
die
diagnostische
therapeutische
Vorgehen
bei
erleichtern
sollen.
Sie
beziehen
sich
insbesondere
auf
Indikationen
zur
schlafmedizinischen
spezifischen
Therapieoptionen
unter
Berücksichtigung
Alter,
Klinik,
Risikofaktoren
Komorbiditäten.
Auswahl
Empfehlungen
orientiert
an
klinischen
Relevanz,
bestehenden
Defiziten
im
Sinne
Über-
oder
Unterversorgung
Stärke
in
aktuellen
S3-Leitlinie
DGSM
den
schlafbezogenen
Atmungsstörungen.